Study on sperm motility and fertility
| Project/Area Number |
19370028
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YOSHIDA Manabu The University of Tokyo, 大学院・理学系研究科附属臨海実験所, 講師 (60301785)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kaoru 桐蔭横浜大学, 先端医用工学センター, 助教 (70398973)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2007: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | 受精 / 精子活性化 / 誘引物質 / 精子受精能阻害物質 / 精子走化性 / 受精能獲得 / カタユウレイボヤ / マウス / 精子活性化・誘引物質 / 動物生理化学 / カタユウレボヤ |
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| Research Abstract |
受精の過程において精子の運動能・受精能が調節されるメカニズムについて解明することを目的とし、本課題においては、主に精子走化性運動調節機構、及び精漿による精子の受精能調節機構の2点に研究内容を絞って研究を推進した。そして、精子走化性においては精子誘引物質による精子鞭毛内Ca^(2+)濃度上昇が鞭毛運動の変化となり、走化性運動に顕著な方向転換となっていること、マウス精子の受精能獲得は精漿タンパク質SVS2が精子表面のガングリオシドGM1と結合することで抑制されること、ヒト精子の受精能抑制は精漿タンパク質SgとZn^(2+)により制御されていることなどが明らかとなった。
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Report
(3 results)
Research Products
(84 results)
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[Journal Article] Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans2009
Author(s)
Yoshida, K., Krasznai, Z.T., Krasznai, Z., Yoshiike, M., Kawano, N., Yoshida, M., Morisawa, M., Toth, Z., Bazsane, Z.K., Marian, T., & Iwamoto, T.
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Journal Title
Cell Motil. Cytoskeleton 66
Pages: 99-108
Related Report
Peer Reviewed
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[Journal Article] Physiological roles of semenogelin and zinc in sperm motility and semen coagulation at ejaculation in human2008
Author(s)
Yoshida, K., Kawano, N., Yoshiike, M., Yoshida, M., Iwamoto, T., & Morisawa, M.
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Journal Title
Mol. Hum. Reprod 14
Pages: 151-156
Related Report
Peer Reviewed
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[Journal Article] Valosin-containing protein/p97 interacts with sperm-activating and sperm-attracting factor (SAAF) in the ascidian egg and modulates sperm-attracting activity.2008
Author(s)
Kondoh, E., Konno, A., Inaba, K., Oishi, T., Murata, M., & Yoshida, M.
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Journal Title
Dev. Growth Differ 50
Pages: 665-673
NAID
Related Report
Peer Reviewed
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[Journal Article] Ascidian sperm activating and attracting factor : Importance of sulfate groups for the activities and implication of its putative receptor2008
Author(s)
Yoshida, M., Yoshida, K., Shiba, K., Tsuchikawa, H., Ootou, O., Oishi, T., & Murata, M.
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Journal Title
FEBS lett 582
Pages: 3429-3433
Related Report
Peer Reviewed
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[Journal Article] Two egg-derived molecules in sperm motility initiation and fertilization in the Pacific herring (Clupea pallasi)2008
Author(s)
Cherr, G.N., Morisawa, M., Vines, C.A., Yoshida, K., Smith, E.H., Matsubara, T., Pillai, M.C., Griffin, F.J., & Yanagimachi, R.
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Journal Title
Int. J. Dev. Biol 52
Pages: 743-752
Related Report
Peer Reviewed
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[Presentation] Valosin containing protein VCP/p97 binds to the sperm attractant SAAF and may control its release from the ascidian egg2008
Author(s)
Kondoh, E., Konno, A., Inaba, K., Oishi, T., Murata, M., and Yoshida, M.
Organizer
41st Society for the Study of Reproduction Annual Meeting
Place of Presentation
Kailua-Kona, HI, USA
Related Report
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[Presentation] How to Track Spermatozoa using High-Speed Visual Feedback2008
Author(s)
Oku, H., Ogawa, J., Shiba, K., Yoshida, M. and Ishikawa, M
Organizer
30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Place of Presentation
Vancouver, British Columbia, Canada
Related Report
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[Presentation] Sperm subpopulation in rainbow trout (Oncorhynchus mykiss)-CASA results and derived phenomenological criteria2008
Author(s)
Kowalski, R.K., Peixinho, J., Shiba, K., Yoshida, K., Sarosiek, B., and Yoshida, M.
Organizer
Aquaculture Europe 08
Place of Presentation
Krakow, Poland
Related Report
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[Presentation] Bovine serum albumin prevents calcium influx induced by ionomycin and progesterone in rainbow trout sperm cells2008
Author(s)
Kowalski, R.K., Glogowski, J., Yoshida, K., Shiba, K., and Yoshida, M.
Organizer
Aquaculture Europe 08
Place of Presentation
Krakow, Poland
Related Report
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[Presentation] Effect of albumin, casein and hemoglobin on short-term preservation of rainbow trout sperm2008
Author(s)
Kowalski, R.K., Yoshida, M., Yoshida, K., Morisawa, M., Shiba, K., Cejko, B.I., and Glogowski, J.
Organizer
Aquaculture Europe 08
Place of Presentation
Krakow, Poland
Related Report
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