Molecular mechanism that induces cytokinesis
| Project/Area Number |
19370080
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Gakushuin University |
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Principal Investigator |
MABUCHI Issei Gakushuin University, 理学部, 教授 (40012520)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 遺伝子 / 細胞・組織 / シグナル伝達 / 生体分子 / 蛋白質 / 細胞 / タンパク質 / 電子顕微鏡 / 細胞質分裂 / 収縮環 / アクチンフィラメント / 細胞分裂 / アクチン / ミオシン / 細胞骨格 / アクチン調節タンパク質 / 分裂シグナル |
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| Research Abstract |
Actin was purified from fission yeast cells for the first time, and it was shown to polymerize into filaments that are indistinguishable from muscle actin filaments. The contractile ring actin filaments were visualized and their directionality was determined. Filaments were shown to shorten during contraction of the ring. We proposed that actin first polymerizes at one point in the division plane to both directions, and then the directionality was mixed in the ring prior to contraction. Using cultured fly cells we showed that myosin molecules in the cytoplasm accumulate at the division cortex during cytokinesis.
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Report
(5 results)
Research Products
(76 results)
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[Presentation] Structure and formation of the contractile ring in fission yeast.2009
Author(s)
Mabuchi, I., Kamasaki, T., Oiwa, Y., Takagi, T., Inoue, S., Shirato, Y., Kashiwazaki, J.
Organizer
The 5th International Fission Yeast Meeting
Place of Presentation
Tokyo
Related Report
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[Presentation] Analysis for Klp8, a unique kinesin-like protein in fission yeast.2009
Author(s)
Kashiwazaki, J., Yoneda, Y., Arai, R., Yoshida, M., Mabuchi, I.
Organizer
The 5th International Fission Yeast Meeting
Place of Presentation
Tokyo
Related Report
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[Book]2008
Author(s)
馬渕一誠
Total Pages
209
Publisher
ウニ卵の収縮環の蛍光像.細胞工学27
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