Relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress

• Project/Area Number: 19380075
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: The University of Tokushima
• Principal Investigator: TERAO Junji The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (60093275)
• Co-Investigator(Kenkyū-buntansha): MUROTA Kaeko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40294681) ; KAWAI Yoshichika 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50380027)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: フラボノイド / 酸化ストレス / ケルセチン / 血管内皮細胞 / 動脈硬化 / 神経細胞 / パーキンソン病 / セロトニン / アミロイドβ / ルテオリン / マクロファージ / ミエロペルオキシダーゼ / エピカテキン / ラジカル捕捉

Research Abstract

This study was aimed to clarify the relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress control using quercetin, an antioxidative flavonoid ubiquitously present in fruits nad vegetables. The results indicate that conjugated quercetin metabolites exert a powerful antioxidant activity after deconjugation via activated macrophage-like cells. It is likely that dietary flavonoids are helpful in the suppression of oxidatives stress occurring in the target sites of intima and CNS by converting to their aglyone under stress-loaded state.

Research Products

• [Journal Article] Suppressive effect of quercetin on acute stess-induced hypothalamic-pituitary-adrenal axis response in Wistar rats. (2010)
  • Author(s): Kawabata K, Kawai Y, Terao J.
  • Journal Title: J. Nutr. Biochem 21 Pages: 374-380
  • Peer Reviewed
• [Journal Article] Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats. (2010)
  • Author(s): K.Kawabata
  • Journal Title: Journal of Nutritional Biochemistry 21 Pages: 374-380
  • Peer Reviewed
• [Journal Article] Dietary flavonoids as antioxidants. (2009)
  • Author(s): Terao J.
  • Journal Title: Forum Nutr. 61 Pages: 87-94
• [Journal Article] Dietary flavonoids as antioxidants (2009)
  • Author(s): J.Terao
  • Journal Title: Forum Nutrition 61 Pages: 87-94
• [Journal Article] ポリフェノールの血中動態と標的部位への蓄積 (2009)
  • Author(s): 寺尾純二
  • Journal Title: 日本未病システム学会雑誌 15 Pages: 43-49
• [Journal Article] Multitargeted cancer prevention by quercetin (review). (2008)
  • Author(s): Murakami A, Ashida H, Terao J.
  • Journal Title: Cancer Lett. 269 Pages: 315-325
  • Peer Reviewed
• [Journal Article] (-)-Epicatechin gallate in foamy macrophages in human atherosclerotic aorta:Implication in the anti-atherosclerotic actions of tea catechins. (2008)
  • Author(s): Kawai Y, Tanaka H, Murota K, Naito M, Terao J.
  • Journal Title: Biochem. Biophys. Res. Comm. 374 Pages: 527-532
  • Peer Reviewed
• [Journal Article] Macrophages as a target of quercetin glucuronides in human atherosclerotic arteries: Implication in the anti-atherosclerotic mechanism of dietary flavonoids. (2008)
  • Author(s): Kawai Y, Nishikawa T, Shiba Y, Saito S, Murota K, Shibata N, Kobayashi M, Kanayama M, Uchida K, Terao J.
  • Journal Title: J. Biol. Chem. 283 Pages: 9424-9434
  • Peer Reviewed
• [Journal Article] Vegetable flavonoids and cardiovascular disease. (2008)
  • Author(s): Terao J, Kawai Y, Murota K.
  • Journal Title: Asian Pac. Clin. Nutr. 17 Pages: 291-293
  • Peer Reviewed
• [Journal Article] Flavonoids as substrates and inhibitors of myeloperoxidase:molecular actions of aglycons and metabolites. (2008)
  • Author(s): Shiba Y, Kinoshita T, Chuman H, Taketani Y, Takeda F, Kate Y, Naito M, Kawabata K, Ishisaka A, Terao J, Kawai Y.
  • Journal Title: Chem Res. Toxicol 21 Pages: 1600-1609
  • Peer Reviewed
• [Journal Article] Flavonoids as substrates and inhibitors of myleoperoxidase : molecular actions of aglycons and metabolites. (2008)
  • Author(s): Shiba Y.
  • Journal Title: Chemical Research in Toxicology 21 Pages: 1600-1609
  • Peer Reviewed
• [Journal Article] (-)Epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta : Implication in the anti-atherosclerotic actions of teacatechins (2008)
  • Author(s): Kawai Y.
  • Journal Title: Biochemical and Biophysical Research Communications. 374 Pages: 527-532
  • Peer Reviewed
• [Journal Article] Multitargeted cancer prevention by quercetin (Review) (2008)
  • Author(s): Murakami A.
  • Journal Title: Cancer Letters 269 Pages: 315-325
  • Peer Reviewed
• [Journal Article] Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries:Implication in the anti-atherosclerotic mechanism of dietary flavonoids (2008)
  • Author(s): Kawai Y
  • Journal Title: Journal of Biological Chemistry 283 Pages: 9424-9434
  • Peer Reviewed
• [Journal Article] Vegetable flavonoids and cardiovascular disease (2008)
  • Author(s): Terao J
  • Journal Title: Asian Pacific Journal of Clinical Nutrition 17(S1) Pages: 291-293
  • Peer Reviewed
• [Presentation] 酸化LDL中の脂質ヒドロペルオキシドに対するHDLの作用 (2010)
  • Author(s): 殊才茉莉
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京都(東京大学)
  • Year and Date: 2010-03-30
• [Presentation] 光照射した培養細胞脂質のヒドロペルオキソド定量分析へのHPTLC法の応用 (2010)
  • Author(s): 島田祥子
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京都(東京大学)
  • Year and Date: 2010-03-30
• [Presentation] 神経細胞Neuro2Aの酸化ストレスに対するケルセチン代謝物の抑制作用 (2009)
  • Author(s): 大塚聖子, 川畑球一, 河合慶親, 寺尾純二
  • Organizer: 第42回日本栄養食糧学会中国・四国支部大会
  • Place of Presentation: 鳥取市
  • Year and Date: 2009-11-08
• [Presentation] 神経細胞Neuro2Aの酸化ストレスに対するケルセチン代謝物の抑制作用 (2009)
  • Author(s): 大塚聖子
  • Organizer: 第42回日本栄養・食糧学会 中国・四国支部大会
  • Place of Presentation: 鳥取市(鳥取大学)
  • Year and Date: 2009-11-08
• [Presentation] タマネギ由来ケルセチンの生体利用性に対するタマネギ加工法の影響 (2009)
  • Author(s): 柏野泰章
  • Organizer: 第42回日本栄養・食糧学会 中国・四国支部大会
  • Place of Presentation: 鳥取市(鳥取大学)
  • Year and Date: 2009-11-08
• [Presentation] 血管内皮細胞を介したLDLの酸化変性に対するオリーブポリフェノールの抑制作用 (2009)
  • Author(s): 神田真衣, 西川朋美, 河合慶親, 室田佳惠子, 中馬寛, 青木由典, 小池泰介, 寺尾純二
  • Organizer: 2009年度日本農芸化学会関西・中四国・西日本支部合同大会
  • Place of Presentation: 那覇市
  • Year and Date: 2009-10-30
• [Presentation] ヒトにおける各種ケルセチン配糖体(Q3G、Q3, 4' G、EMIQ)の吸収性比較 (2009)
  • Author(s): 室田佳恵子
  • Organizer: 2009年度日本農芸化学会関西・中四国・西日本支部合同大会
  • Place of Presentation: 那覇市'(琉球大学)
  • Year and Date: 2009-10-30
• [Presentation] 血管内皮細胞を介したLDLの酸化変性に対するオリーブポリフェノールの抑制作用 (2009)
  • Author(s): 神田真衣
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 那覇市(琉球大学)
  • Year and Date: 2009-10-30
• [Presentation] FSFパイオニアの現在過去未来 (2009)
  • Author(s): 寺尾純二
  • Organizer: 第19回フードサイエンスフォーラム
  • Place of Presentation: 伊東市(ヤクルト研修所)
  • Year and Date: 2009-09-02
• [Presentation] Anti-atheroslcerotic effect of polyphenols:Role of metabolic conversion and transport to the target site. (2009)
  • Author(s): Terao J, Murota K, Kawai Y.
  • Organizer: International Conference on Polyphenols 2008
  • Place of Presentation: Salamanca, SPAIN
  • Year and Date: 2009-07-09
• [Presentation] ケルセチン代謝物のマウス脳モノアミンオキシダーゼA活性抑制作用 (2009)
  • Author(s): 吉野早紀, 川畑球一, 徳村彰, 河合慶親, 寺尾純二
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-06-11
• [Presentation] ケルセチン代謝物のマウス脳モノアミンオキシダーゼ-A活性抑制作用 (2009)
  • Author(s): 寺尾純二
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 福岡市(九州大学)
  • Year and Date: 2009-06-11
• [Presentation] Antioxidative flavonoid quercetin : metabolic conversionbehind its anti-atherosclerotic effect (2008)
  • Author(s): Terao J.
  • Organizer: International Symposium on Lipid Peroxidation 2008
  • Place of Presentation: Karuizawa, Japan
  • Year and Date: 2008-10-17
• [Presentation] Mechanistic approach to anti-atheroslerotic effect of tea catechins. (2008)
  • Author(s): Terao J, Kawai Y.
  • Organizer: International Symposium and Annual nieeting of Korean Society for Food and Nutrition
  • Place of Presentation: Jeju Island, KOREA
  • Year and Date: 2008-10-14
• [Presentation] Mechanistic approach to anti-atherosclerotic effect of teacatechins (2008)
  • Author(s): Terao J.
  • Organizer: International Symposium and Annual Meeting of Korean Society of Food and Nutrition
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-10-14
• [Presentation] Antioxidative flavonoids quercetin:metabolic conversion behind its anti-atherosclerotic effect. (2008)
  • Author(s): Terao J, Murota K, Kawai Y.
  • Organizer: International symposium on lipid peroxidation 2008
  • Place of Presentation: Karuizawa, JAPAN
  • Year and Date: 2008-10-07
• [Presentation] Anti-atherosclerotic effect of polyphenols : role of metabolic conversion and transport to the target site (2008)
  • Author(s): Terao J.
  • Organizer: International Conference on Polyphenols2008
  • Place of Presentation: Salamanca, Spain
  • Year and Date: 2008-07-09
• [Presentation] Anti-atheroslcerotic effect of vegetable flavonoids. (2008)
  • Author(s): Terao J, Murota K, Kawai Y.
  • Organizer: Italian-Japanese joint symposium-National Products and functional Foods
  • Place of Presentation: Salerno, ITALIA
  • Year and Date: 2008-06-28
• [Presentation] Anti-atherosclerotic effect of vegetable flavonoids (2008)
  • Author(s): Terao J.
  • Organizer: Italian-Japanese Joint Symposium Natural products and functional Foods
  • Place of Presentation: Salerno, Italia
  • Year and Date: 2008-06-28
• [Presentation] Availability and behavior of dietary flavonoids in the target site. (2007)
  • Author(s): Terao j, Murota K, Kawai Y.
  • Organizer: 2nd International Symposium on Translational Research on Natural Products and cancer
  • Place of Presentation: Lanavala, Munbai, INDIA
  • Year and Date: 2007-12-11
• [Presentation] Availability and behavior of dietary flavonoids in the target site (2007)
  • Author(s): Terao J
  • Organizer: 2^<nd> International symposium on translational research on natural products and cancer
  • Place of Presentation: Lanavala,Munbai,INDIA
  • Year and Date: 2007-12-11
• [Presentation] Antioxidant activity and physiological significance of flavonoid metabolites. (2007)
  • Author(s): Terao J, Murota K, Kawai Y.
  • Organizer: 9th International Conference of Antimutagenesis and Anticarcinogenesis
  • Place of Presentation: Jeju Island KOREA
  • Year and Date: 2007-12-05
• [Presentation] Antioxidant activity and physiological significance of flavonoid metabolites (2007)
  • Author(s): Terao J
  • Organizer: 9^<th> International Conference of Mechanism of antimutagenesis and antiarcinogenesis
  • Place of Presentation: Jeju Island KOREA
  • Year and Date: 2007-12-05
• [Book] in Plant Phenolics and Human Health (2009)
  • Author(s): Terao J.
  • Total Pages: 13
  • Publisher: Metabolism
• [Book] Flavonols : Metabolism, Bioavailability, and Health Impacts, (in Plant Phenolics and Human Health) (2009)
  • Author(s): J.Terao
  • Total Pages: 13
  • Publisher: A John Wiley & sons, Inc
• [Remarks]
  • URL: http://www.hosp.med.tokushima-u.ac.jp/university/servlet/index/index?&level=4&reference=0/10002/5/30010/20033