Establishment of novel preventive/therapeutic measures and demonstration of a mechanism of neural spread of pathogens in neurotropic zoonotic diseases
| Project/Area Number |
19380171
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
UMEMURA Takashi Hokkaido University, 大学院・獣医学研究科, 教授 (00151936)
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| Co-Investigator(Kenkyū-buntansha) |
PARK Chon-ho 北里大学, 獣医畜産学部, 准教授 (50383550)
KIDA Hiroshi 北海道大学, 大学院・獣医学研究科, 教授 (10109506)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 狂犬病 / 鞘内免疫 / インフルエンザウイルス / 小児脳症 / オーエスキー病 / 血球凝集性脳脊髄炎ウイルス / インフルエンザ脳症 / 野兎病 / 人獣共通感染症 / 脳内免疫 / LPS / 経神経伝播 / ワクチン / 人畜共通感染症 |
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| Research Abstract |
Specific antibodies detected in cerebrospinal fluid by intrathecal vaccination (vaccination by an inoculating antigen into subarachnoidal space) were produced de novo in the brain. Intrathecal vaccination completely prevented clinical signs and death of mice inoculated with rabies or pseudorabies viruses. Eighty percent of the mice intrathecally vaccinated and inoculated rabies virus directly into the brain survived, and this result suggested that the intrathecal vaccination was applicable for the treatment of rabid animals and humans. Our novel murine model of influenzal encephalopathy of childhood suggested hypercytokinemia triggered by influenza virus infection and/or a duplication of influenza virus infection and endotoxemia might be the cause(s) of the disease.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Pathological and microbiological studies of Japanese hare (Lepus braehyurus angustidens) naturally infected with Francisella tularensissubsp. holarctica.2009
Author(s)
Park CH, Nakanishi A, Hatai H, Kojima D, Oyamada T, Sato H, Kudo N, Shindo J, Fujita O, Hotta A, Inoue S, Tanabayashi K
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Journal Title
J Vet Med Sci 71
Pages: 1629-1635
Related Report
Peer Reviewed
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[Journal Article] Pathological and microbiological studies of Japanese hare (Lepus brachyurus angustidens) naturally infected with Francisella tularensis subsp. holarctica2009
Author(s)
Park CH, Nakanishi A, Hatai H, Kojima D, Oyamada T, Sato H, Kudo N, Shindo J, Fujita O, Hotta A, Inoue S, Tanabayashi K
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Journal Title
Journal of Veterinary Medical Science 71
Pages: 1629-1635
Related Report
Peer Reviewed
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