| Project/Area Number |
19380175
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TSUJIMOTO Hajime The University of Tokyo, 大学院・農学生命科学研究科, 教授 (60163804)
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Koichi 東京大学, 大学院・農学生命科学研究科, 准教授 (90294660)
FUJINO Yasuhito 東京大学, 大学院・農学生命科学研究科, 助教 (70401180)
GOTO Yuko 東京大学, 大学院・農学生命科学研究科, 特任助教 (80436518)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 犬 / 化学療法 / 骨髄移植 / CD34 / 造血幹細胞 / リンパ腫 / ABCB1遺伝子 / P-糖タンパク / 治療 / 凍結保存 / リンパ系腫瘍 / 高用量化学療法 |
|---|
| Research Abstract |
To advance antineoplastic therapies for lymphohematopoietic tumors that are common in dogs, we developed a series of systems for autologous bone marrow transplantation. Optimal conditions for bone marrow cell collection, hematopoietic cell separation, and their cryopreservation were obtained. Next, hematopoietic stem cells resistant to antineoplastic agents were generated by a gene transfer method. Finally, we developed a higly sensitive quantitative monitoring system of minimal residual disease to assess the treatment efficacy. The present study provided a basis for the development of antineoplastic therapies with excellent treatment outcomes.
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