Study on development of novel drugs possessing therapeutic potentials for intractable brain diseases-aiming at GIRK channel as their molecular target
| Project/Area Number |
19390066
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
TAKAHAMA Kazuo Kumamoto University, 大学院・生命科学研究部, 教授 (80150548)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRASAKI Tetsuya 熊本大学, 大学院・生命科学研究部, 准教授 (30264047)
SOEDA Fumio 熊本大学, 大学院・生命科学研究部, 助教 (10336216)
山村 研一 熊本大学, 学内共同利用施設, 教授 (90115197)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMURA Kenichi 熊本大学, 生命資源研究・支援センター, 教授 (90115197)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | GIRKチャネル / 難治性脳疾患 / 治療抵抗性うつ病 / ドパミン / NMR / チペピジン / 強迫性症候群 / パーキンソン病 / クロペラスチン / セロトニン / 難治性うつ病 / 排尿障害 / GIRK2コンデイショナルノックメアウトマウス / 難治性うつ病モデル / GIRK2サブユニット / GIRK2コンデイショナルノックアウトマウス |
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| Research Abstract |
Tipepidine which has a blocking action on G-protein-coupled inwardly rectifying K ion channel revealed the improved actions in animal model of depression resistant to drug treatment, Parkinson disease and compulsive behaviors.These actions were produced at antitussive effective doses and through a novel mechanism. Tipepidine showed a relatively high selective action on GIRK channels. Combination study of NMR and gene expression system revealed that cloperastine may interact directly with E300, I302, C310 and Q311 of GIRK 1 subunit.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats2009
Author(s)
Kawaura, K., Ogata, Y., Inoue, M., Honda, S., Soeda, F., Shirasaki, T., Takahama, K
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Journal Title
Behavioral Brain Res 205
Pages: 315-318
NAID
Related Report
Peer Reviewed
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[Presentation] Studies on mechanisms of a novel antidepressant- like effect of tipepidine possessing GIRK channel inhibiting action in rats2010
Author(s)
Kawaura, K., Miki, R., Honda, S., Soeda, F., Shirasaki, T., Takahama, K
Organizer
第83回日本薬理学会年会
Place of Presentation
大阪
Related Report
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[Presentation] A novel antidepressant-like effect of antitussives possessing pleiotropic pharmacological activity2009
Author(s)
Kawaura, K., Ogata, Y., Honda, Soeda, F., Shirasaki, T., Takahama, K
Organizer
第39回米国神経科学会
Place of Presentation
シカゴ, 米国
Related Report
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[Presentation] Enriched environment promotes micuturition activity of freely moving mice2009
Author(s)
Soeda, F., Miki, R., Masuzaki, K., Yamamoto, G., Shirasaki, T., Takahama, K
Organizer
第39回北米神経科学会
Place of Presentation
シカゴ, 米国
Related Report
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[Presentation] Ameliorating effect of cloperastine on tricyclic antidepressant-resistant depression rats2009
Author(s)
Ogata, Y., Kawaura, K., Honda, S., Soeda, F., Shirasaki, T., Takahama, K
Organizer
第82回日本薬理学会年会
Place of Presentation
横浜
Related Report
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