Roles of obesity and dietary factors on multistage carcinogenesis and risk assessment
| Project/Area Number |
19390161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
MURATA Mariko Mie University, 大学院・医学系研究科, 教授 (10171141)
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| Co-Investigator(Kenkyū-buntansha) |
OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006)
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 食餌性因子 / 肥満 / 発がん / DNA損傷 / 細胞増殖作用 / 遺伝子発現 / フタル酸エステル / 酸化的DNA損傷 / 女性ホルモン作用 / ペルオキシゾーム増殖 / 脂肪蓄積作用 / 高血糖 / 代謝酵素活性化 / 発がんリスク / 2-nitrotoluene / 2-nitrosotoluene / 遺伝子損傷 / 活性酸素 / 8-オキソデオキシグアノシン / エストロゲン活性 / 内分泌撹乱作用 / 女性生殖器発がん / クロロゲン酸 / 銅 / マンガン / NADH / 過酸化水素 |
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| Research Abstract |
Estimates suggest that 35% of all human cancers have a linkage to dietary and obesity. Several reports showed the evidences of an association between obesity and cancer derives from cohort studies. To clarify the roles of obesity and dietary factors on multistage carcinogenesis and risk assessment, we examined DNA damage and ability for cell proliferation for chlorogenic acid, 2-nitrotoluene, phthalate and status of high glucose and oxidative stress. These factors could cause DNA damage and gene expression under several conditions, and therefore further studies are needed to prevent cancers due to dietary factors and obesity.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine in patients with parasite infection and the effect of anti-parasitic drug in relation to cholangiocarcinogenesis.2008
Author(s)
Thanan R., Murata M, Pinlaor S, Sithithaworn P, Khuntikeo N, Tangkanakul W, Hiraku Y, Oikawa S, Yongvanit P, Kawanishi S
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Journal Title
Cancer Epidemiol Biomarkers Prev 17(3)
Pages: 518-24
Related Report
Peer Reviewed
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[Journal Article] Urinary8-oxo-7,8-dihydro2-deoxyguanosine in patients with parasite infection and the effect of anti-parasitic drug in relation to cholangiocarcinogenesis.2008
Author(s)
R.Thanan, M.Murata, S.Pinlaor, P.Sithithaworn, N.Khuntikeo, W.Tangkanakul, Y.Hiraku, S.Oikawa, P.Yongvanit, S.Kawanishi
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Journal Title
Cancer Epidemiology Biomarkers & Prevetion (印刷中)
Related Report
Peer Reviewed
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