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A longitudinal study on risk factors of mild dementia

Research Project

Project/Area Number 19390178
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

WATANABE Yoshiyuki  Kyoto Prefectural University of Medicine, 大学院・医学研究科, 教授 (00191809)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Masanori  京都府立医科大学, 大学院・医学研究科, 准教授 (50198040)
MIZUNO Toshiki  京都府立医科大学, 大学院・医学研究科, 准教授 (30264782)
YAMADA Kei  京都府立医科大学, 大学院・医学研究科, 講師 (80315960)
KONDOU Masaki  京都府立医科大学, 大学院・医学研究科, 助教 (20315964)
KURIYAMA Nagato  京都府立医科大学, 大学院・医学研究科, 助教 (60405264)
MITANI Satoko  京都府立医科大学, 大学院・医学研究科, 助教 (90423053)
OZAKI Etsuko  京都府立医科大学, 大学院・医学研究科, プロジェクト研究員 (00438219)
小笹 晃太郎  京都府立医科大学, 医学研究科, 准教授 (20204191)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords軽度認知機能障害 / 脳MRI / 大脳白質病変 / 動脈硬化症 / 脳虚血
Research Abstract

軽度認知症のリスク要因として、加齢と脳画像診断のMRI検査における大脳白質病変が、より早期の軽度認知機能障害のリスクとして、加齢、女性、運動不足が見出された。特に、大脳白質病変が中等度以上にある場合、そうでない場合と比較して約9倍だけ軽度認知症のリスクを高めていた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Evaluation of factors associated with elevated levels of platelet-derived microparticles in the acute phase of cerebral infarction2010

    • Author(s)
      Kuriyama N, Nagakane Y, Hosomi A, Ohara T, Kasai T, Harada S, Takeda, K, Yamada K, Ozasa K, Tokuda T, Watanabe Y, Mizuno T, Nakagawa M.
    • Journal Title

      Clin Appl Thromb Hemost. 16 (1)

      Pages: 26-32

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictive markers of blood cytokine and chemokine in recurrent brain infarction2009

    • Author(s)
      Kuriyama N, Mizuno T, Kita M, Nagakane Y, Hosomi A, Harada S, Takeda K, OzasaK, Yamada K, Tokuda T, Watanabe Y, Nakagawa M, et al.
    • Journal Title

      Journal of Interferon & Cytokine Research (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictive markers of blood cytokine and chemokine in recurrent brain infarction2009

    • Author(s)
      Kuriyama N, Mizuno T, Ozasa K, Watanabe Y, Nakagawa Metal.
    • Journal Title

      Journal of Interferon & Cytokine Research (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of factors associated with elevated levels of platelet- derived microparticles in the acute phase of cerebral infarction2009

    • Author(s)
      Kuriyama N, Ozasa K, Watanabe Y, Mizuno T, Nakagawa M, et al.
    • Journal Title

      Clinical and Applied Thrombosis/Hemostasis (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Longitudinal study of risk factors for intracranial deep white matter lesions2010

    • Author(s)
      Kuriyama N, Mizuno T, Mitani S, Ozaki E, Shigeta M, Matsumoto S, Takeda K, Yamada K, Nakagawa M, Watanabe Y
    • Organizer
      The Joint Scientific Meeting of IEA (International Epidemiological Association) Western Pacific Region and Japan Epidemiological Association
    • Place of Presentation
      Saitama
    • Year and Date
      2010-01-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳虚血・白質病変の進行に関与する危険因子の前向き縦断的検討2009

    • Author(s)
      栗山長門, 水野敏樹, 大島洋一, 笠井高士, 山田丈弘, 松本早苗, 武田和夫, 山田恵, 中川正法, 渡邊能行, 他
    • Organizer
      第34回日本脳卒中学会総会
    • Year and Date
      2009-03-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳虚血・白質病変の進行に関与する危険因子の前向き縦断的検討2008

    • Author(s)
      栗山, 水野, 中川, 渡邊ら
    • Organizer
      第34回日本脳卒中学会総会
    • Place of Presentation
      松江市、島根
    • Year and Date
      2008-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 動脈硬化および生活習慣の認知機能検査への影響について2007

    • Author(s)
      水野敏樹, 近藤正樹, 栗山長門, 原田早苗, 武田和夫, 渡邊能行, 中川正法
    • Organizer
      第49回日本老年医学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 生活習慣・動脈硬化の認知機能検査に対する関与2007

    • Author(s)
      水野敏樹, 近藤正樹, 栗山長門, 三谷智子, 尾崎悦子, 原田早苗, 武田和夫, 渡邊能行, 中川正法
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-18
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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