Regulatory Mechanism of Brain-Gut Interactions by Brain-Gut Peptides

• Project/Area Number: 19390189
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: FUKUDO Shin Tohoku University, 大学院・医学系研究科, 教授 (80199249)
• Co-Investigator(Kenkyū-buntansha): KANAZAWA Motoyori 東北大学, 大学院・医学系研究科, 講師 (70323003)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
• Keywords: 脳腸相関 / 過敏性腸症候群 / corticotropin-releasing hormone (CRH) / 内臓感覚 / 消化管運動 / 脳画像 / CRH-R1受容体 / α-helical CRH / corticotropin-releasing hormone(CRH) / CRH / 消化管知覚 / CRH-R1

Research Abstract

It is important to clarify the precise mechanism of brain-gut interactions and pathogenesis of irritable bowel syndrome (IBS). We focused on the role of corticotropin-releasing hormone (CRH) in these phenomena. Administration of non-peptide CRH antagonist improved visceral hypersensitivity and flare-up of inflammation in the animal model of IBS after the experimental colitis. Administration of peptide CRH antagonist improved electrophysiological properties of the brain in patients with IBS. Further studies on brain-gut peptides in this issue are warranted.

Research Products

• [Journal Article] Site-specific differences in central processing of visceral stimuli from the rectum and the descending colon in men (2010)
  • Author(s): Kanazawa M, et al.
  • Journal Title: Neurogastroenterol Motil 22 Pages: 173-180
  • Peer Reviewed
• [Journal Article] Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome (2010)
  • Author(s): Tana C, et al.
  • Journal Title: Neurogastroenterol Motil 22 Pages: 512-519
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 福土審(分担執筆)
  • Journal Title: 過敏性腸症候群:今日の診療のためにガイドライン外来診療2010(日経メディカル開発,東京) Pages: 156-162
• [Journal Article] Increased brain histamine H1 receptor binding in patients with anorexia nervosa. (2009)
  • Author(s): Yoshizawa M, Tashiro M (Equally Contributing First Author), Fukudo S, Yanai K, Utsumi A, Kano M, Karahasi M, Endo Y, Morisita J, Sato Y, Adachi M, Itoh M, Hongo M
  • Journal Title: Biol Psychiatry 65 Pages: 329-335
  • Peer Reviewed
• [Journal Article] Brain activation correlates with changes in heart rate and autonomic function during rectal distention. (2009)
  • Author(s): Suzuki H, Watanabe S, Hamaguchi T, Mine H, Terui T, Kanazawa M, Oohisa N, Maruyama M, Yambe T, Itoh M, Fukudo S
  • Journal Title: Psychosom Med 71 Pages: 619-626
  • Peer Reviewed
• [Journal Article] Is colonic hypersensitivity realy a biological marker of irritable bowel syndrome (IBS)? A role of visceral sensitivity on pathophysiology of IBS. Chapter IV. (2009)
  • Author(s): Kanazawa M, Fukudo S
  • Journal Title: Driggers J, Pellegrino C, edts., Irritable Bowel Syndrome(Nova Science Publishers)
  • Peer Reviewed
• [Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention. (2009)
  • Author(s): Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M
  • Journal Title: Neuroimage 47 Pages: 946-951
  • Peer Reviewed
• [Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention (2009)
  • Author(s): Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M.
  • Journal Title: Neuroimage 47 Pages: 946-951
  • Peer Reviewed
• [Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention (2009)
  • Author(s): Fukudo S, et al.
  • Journal Title: Neuroimage 47 Pages: 946-951
  • Peer Reviewed
• [Journal Article] Cross cultural perspective of irritable bowel syndrome in Japan. (2008)
  • Author(s): Fukudo S
  • Journal Title: Functional Brain-Gut Research Group Newsletter 41 Pages: 10-11
  • Peer Reviewed
• [Journal Article] IBS Club. High Prevalence of Irritable Bowel Syndrome in Medical Outpatients in Japan. (2008)
  • Author(s): Shinozaki M, Fukudo S, Hongo M, Shimosegawa T, Sasaki D, Matsueda K, Harasawa S, Miura S, Mine T, Kaneko H, Arakawa T, Haruma K, Torii A, Azuma T, Miwa H, Fukunaga M, Handa M, Kitamori S, Miwa T
  • Journal Title: J Clin Gastroenterol 42 Pages: 1010-1016
  • Peer Reviewed
• [Journal Article] Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension. (2008)
  • Author(s): Saito-Nakaya K, Hasegawa R, Nagura Y, Ito H, Fukudo S
  • Journal Title: Neurogastroenterol Motil 20 Pages: 1147-1156
  • Peer Reviewed
• [Journal Article] Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits. (2008)
  • Author(s): Kanazawa M, Palsson OS, Thiwan SIM, Turner MJ, van Tilburg MAL, Gangarosa LM, Chitkara DK, Fukudo S, Drossman DA, Whitehead WE
  • Journal Title: Am J Gastroenterol 103 Pages: 2550-2561
  • Peer Reviewed
• [Journal Article] Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome. (2008)
  • Author(s): Hamaguchi T, Fukudo S, Kanazawa M, Tomiie T, Shimizu K, Oyama M, Sakurai K
  • Journal Title: Biopsychosoc Med 2 Pages: 20-20
  • Peer Reviewed
• [Journal Article] Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension (2008)
  • Author(s): Saito-Nakaya K, Hasegawa R, Nagura Y, Ito H, Fukudo S.
  • Journal Title: Neurogastroenterol Motil 20 Pages: 1147-1156
  • Peer Reviewed
• [Journal Article] Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension (2008)
  • Author(s): Saito-Nakaya K
  • Journal Title: Neurogastroenterol Motil 20 Pages: 1147-1156
  • Peer Reviewed
• [Journal Article] Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits (2008)
  • Author(s): Kanazawa M,
  • Journal Title: Am J Gastroenterol 103 Pages: 2550-2561
  • Peer Reviewed
• [Journal Article] Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome (2008)
  • Author(s): Hamaguchi T
  • Journal Title: Biopsychosoc Med 2(E-publication) Pages: 20-20
  • Peer Reviewed
• [Journal Article] Effect of alpha-helical CRH on quantitative electroencephalogram in patients with irritable bowel syndrome. (2007)
  • Author(s): Tayama J, Sagami Y, Shimada Y, Hongo M, Fukudo S
  • Journal Title: Neurogastroenterol Motil 19 Pages: 471-483
  • Peer Reviewed
• [Journal Article] Translation and validation of a Japanese version of the irritable bowel syndrome-quality of life measure (IBS-QOL-J). (2007)
  • Author(s): Kanazawa M, Drossman DA, Shinozaki M, Sagami Y, Endo Y, Palsson OS, Hongo M, Whitehead WE, Fukudo S
  • Journal Title: BioPsychoSoc Med 1:6(epub)
  • Peer Reviewed
• [Journal Article] Correlation between alexithymia and hypersensitivity to visceral stimulation in human. (2007)
  • Author(s): Kano M, Hamaguchi T, Itoh M, Yanai K, Fukudo S
  • Journal Title: Pain 132 Pages: 252-263
  • Peer Reviewed
• [Journal Article] Role of histaminergic neurons in hypnotic modulation of brain processing of visceral perception. (2007)
  • Author(s): Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S
  • Journal Title: Neurogastroenterol Motil 19 Pages: 831-838
  • Peer Reviewed
• [Journal Article] Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation. (2007)
  • Author(s): Fukudo S
  • Journal Title: J Gastroenterol 42(Suppl 17) Pages: 48-51
  • NAID: 10018539958
  • Peer Reviewed
• [Journal Article] Effect of alpha-helical CRH on quantitative electroencephalogram in patients with irritable bowel syndrome (2007)
  • Author(s): Tayama J, Sagami Y, Shimada Y, Hongo M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil 19 Pages: 471-483
  • Peer Reviewed
• [Journal Article] Effect of alpha-helical CRH on quantitative electroencephalogram in patients with irritable bowel syndrome (2007)
  • Author(s): Tayama, J., et al.
  • Journal Title: Neurogastroenterol. Motil. 19 Pages: 471-483
  • Peer Reviewed
• [Journal Article] Sex and gender in irritable bowel syndrome (2007)
  • Author(s): Fukudo, S.
  • Journal Title: J Gastroenterol 42(Suppl 17) Pages: 48-51
  • NAID: 10018170770
  • Peer Reviewed
• [Journal Article] Brain-gut interactions in irritable bowel syndrome (2007)
  • Author(s): Fukudo, S.
  • Journal Title: Psychosom. Med. 69
  • Peer Reviewed
• [Journal Article] (2007)
  • Author(s): 福土審, 分担執筆
  • Journal Title: 杉本恒明, 矢崎義男総編集:内科学, 第9版(朝倉書店, 東京) Pages: 875-877
• [Presentation] Inveited Lecture : Cutting Edge of Irritable Bowel Syndrome. Genomic studies of irritable bowel syndrome : What's new? (2009)
  • Author(s): Shin Fukudo
  • Organizer: Seoul International Digestive Disease Symposium 2009 (SIDDS 2009)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-11-18
• [Presentation] Invited Lecture of Symposium : Advances in Enteral Nutrition. Gut-Brain Hormones in Mediating Gastrointestinal Function. (2009)
  • Author(s): Shin Fukudo
  • Organizer: The Asian Pacific Digestive Week 2009
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2009-09-29
• [Presentation] Invited Lecture of Symposium : The Bi-directional Role of Brain and Gut in Functional Gastrointestinal Disorders (FGIDs). Visceral Pain Neuro-pathways in FGIDs. (2009)
  • Author(s): Shin Fukudo
  • Organizer: The Asian Pacific Digestive Week 2009
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2009-09-28
• [Presentation] Invited Lecture : Therapeutic strategy for functional gastrointestinal disorders : How to treat functional dyspepsia. (2009)
  • Author(s): Shin Fukudo
  • Organizer: The Symposium on Functional Gastrointestinal Disorders in China.
  • Place of Presentation: Guangzhou, China
  • Year and Date: 2009-07-14
• [Presentation] Invited Lecture : Therapeutic strategy for functional gastrointestinal disorders: How to treat functional dyspepsia. (2009)
  • Author(s): Shin Fukudo
  • Organizer: The Symposium on Functional Gastrointestinal Disorders in China.
  • Place of Presentation: Wuhan, China
  • Year and Date: 2009-07-12
• [Presentation] Invited Lecture : Therapeutic strategy for functional gastrointestinal disorders : How to treat functional dyspepsia. (2009)
  • Author(s): Shin Fukudo
  • Organizer: The Symposium on Functional Gastrointestinal Disorders in China.
  • Place of Presentation: Shanghai, China
  • Year and Date: 2009-07-11
• [Presentation] Normal and abnormal processing of negative emotion by visceral stimulation. Workshops : Brain-Gut Axis. (2009)
  • Author(s): Shin Fukudo
  • Organizer: The 8th International Symposium on Functional Gastrointestinal Disorders.
  • Place of Presentation: Milwaukee, USA
  • Year and Date: 2009-04-18
• [Presentation] Normal and abnormal processing of negative emotion by visceral stimulation. Workshops : Brain-Gut Axis (2009)
  • Author(s): Fukudo S.
  • Organizer: The 8th International Symposium on Functional Gastrointestinal Disorders
  • Place of Presentation: Milwaukee, USA
  • Year and Date: 2009-04-18
• [Presentation] Invited Lecture : Recent Features of Irritable Bowel Syndrome. (2009)
  • Author(s): Shin Fukudo
  • Organizer: The Executive Meeting of the Asian Neurogastroenterology and Motility Association
  • Place of Presentation: Shanghai, China
  • Year and Date: 2009-01-10
• [Presentation] Invited Lecture : Role of corticotropin-releasing hormone in irritable bowel syndrome. (2008)
  • Author(s): Shin Fukudo
  • Organizer: The International Symposium on Biologically Active Peptides : Peptide Diversity
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2008-09-01
• [Presentation] Master Lecture : Emotion, Behaviors and Brain-Gut Interactions. (2008)
  • Author(s): Shin Fukudo
  • Organizer: The 10th Annual Meeting of the International Society of Behavioral Medicine
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-08-29
• [Presentation] Effect of 5-HT_<2A/2C> receptor agonist on maternally separated rats mimicking irritable bowel syndrome (2008)
  • Author(s): Fukudo S, Gu Li, et.al.
  • Organizer: The 109th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-05-18
• [Presentation] Invited Lecture of the 2nd Joint Symposium of Korea-Japan-China Joint Session : Translational Research in GI Motility : from Basic to Clinical : Brain-Gut Interactions in Irritable Bowel Syndrome. (2008)
  • Author(s): Shin Fukudo
  • Organizer: The 18th Scientific Conference of Korean Society of Neurogastroenetrology and Motility
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-03-29
• [Presentation] Invited Lecture of the Dyspepsia Symposium of Asia : Brain-Gut Function in Irritable Bowel Syndrome. (2008)
  • Author(s): Shin Fukudo
  • Organizer: The 1st Meeting of Asian Neurogastroenetrology and Motility Association
  • Place of Presentation: Bangkok, Thai
  • Year and Date: 2008-03-21
• [Presentation] Invited Lecture : Irritable Bowel Syndrome. Impact of gut-to-brain signal in normal and pathological conditions. (2007)
  • Author(s): Shin Fukudo
  • Organizer: The 21st International Symposium on Neurogastroenterology and Motility
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2007-09-02
• [Presentation] Invited Lecture : Gastrointestinal Motility and Functional Gastroentestinal Disorders, Basic to Clinical. Substance relating brain-gut interactions in irritable bowel syndrome. (2007)
  • Author(s): Shin Fukudo
  • Organizer: The 4th Pfizer Science and Research Symposium.
  • Place of Presentation: Nagoya Congress Center, Nagoya, Japan
  • Year and Date: 2007-08-28
• [Presentation] Brain-Gut axis in irritable bowel syndrome : role of corticotropin-releasing hormone (2007)
  • Author(s): Fukudo, S.
  • Organizer: The 7th International Symposium on Functional Gastrointestinal Disorders
  • Place of Presentation: Milwaukee, WN, USA
  • Year and Date: 2007-04-13
• [Book] Rome III[日本語版] 機能性消化管障害 (2008)
  • Author(s): 福土審,本郷道夫,松枝啓(監訳)
  • Publisher: 協和企画
• [Book] わかりやすい内科学, 第3版(井村裕夫編)(過敏性腸症候群) (2008)
  • Author(s): 福土審
  • Publisher: 文光堂
• [Book] Rome III [日本語版] 機能性消化管障害 (2008)
  • Author(s): 福土審, 本郷道夫, 松枝啓, 監訳
  • Publisher: 協和企画
• [Book] 過敏性腸症候群の病態生理 : 消化管炎症. 松枝啓編, 過敏性腸症候群の診断と治療-Rome III新診断基準を踏まえた合理的アプローチ- (2008)
  • Author(s): 福土審(分担執筆)
  • Publisher: 医薬ジャーナル, 大阪
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