New challenges to chronic airway diseases-pathogenesis, diagnosis and treatment-

• Project/Area Number: 19390221
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: NISHIMURA Masaharu Hokkaido University, 大学院・医学研究科, 教授 (00208224)
• Co-Investigator(Kenkyū-buntansha): HIZAWA Nobuyuki 筑波大学, 大学院・人間総合科学研究科, 教授 (00301896) ; BETSUYAKU Tomoko 北海道大学, 大学院・医学研究科, 准教授 (60333605) ; NASUHARA Asuyuki 北海道大学病院, 准教授 (30322811)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2007: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
• Keywords: 酸化ストレス / 気道炎症, / 気管支喘息 / 動物モデル / 喫煙 / 気道炎症

Research Abstract

難治性の気道疾患という観点から慢性閉塞性肺疾患(Chronic obstructive pulmonary disease : COPD)と気管支喘息をとらえ、その克服をめざしたものである。近年、酸化ストレスが、COPD、気管支喘息の病態に様々な形で関与すると考えられており、具体的には1)治療標的の特定を目指す病態の解明、2)低侵襲的気道病態の評価法の開発(新規酸化ストレスバイオマーカー・3次元的気道画像解析)、3)抗酸化剤治療介入へ向けての基礎的研究、4)北海道COPDコホート研究という4つのプロジェクトからなる。

Research Products

• [Journal Article] Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice (2009)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 296 Pages: 614-623
  • Peer Reviewed
• [Journal Article] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergics in chronic obstructive pulmonary disease (2009)
  • Author(s): Hasegawa M, Makita H, Nasuhara Y, Nagai K, Ito Y, Odajima N, Betsuyaku T, Nishimura M.
  • Journal Title: Thorax 64 Pages: 332-338
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinases in blood from patients with LAM (2009)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M.
  • Journal Title: Respir Med 103 Pages: 124-129
  • Peer Reviewed
• [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages (2009)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M.
  • Journal Title: Free Radic Res 10(2) Pages: 173-180
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinases in blood from patients with LAM (2009)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M
  • Journal Title: Respir Med 103 Pages: 124-129
  • Peer Reviewed
• [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages (2009)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
  • Journal Title: Biogerontology 10 Pages: 173-180
  • Peer Reviewed
• [Journal Article] Diversity of protein carbonylation in allergic airway inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M.
  • Journal Title: Free Radic Res 42 Pages: 921-929
  • Peer Reviewed
• [Journal Article] Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease (2008)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M.
  • Journal Title: Am J Respir Cell Mol Biol 39 Pages: 673-682
  • Peer Reviewed
• [Journal Article] Hokkaido COPD Cohort Study Group. : "Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients" (2008)
  • Author(s): Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M.
  • Journal Title: Eur Respir J 32 Pages: 372-378
  • Peer Reviewed
• [Journal Article] the Hokkaido COPD Cohort Study Group. : "Functional SNPs of the CCL5 gene and non-emphysematous phenotype in patients with COPD" (2008)
  • Author(s): Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M
  • Journal Title: Eur Respir J 32 Pages: 372-378
  • Peer Reviewed
• [Journal Article] Diversity of protein carbonylation in allergic airway inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
  • Journal Title: Free Radic Res 42 Pages: 921-929
  • Peer Reviewed
• [Journal Article] Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease (2008)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S. Nishimura M
  • Journal Title: Am J Respir Cell Mol Biol 39 Pages: 673-682
  • Peer Reviewed
• [Journal Article] Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients (2008)
  • Author(s): Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M ; Hokkaido COPD Cohort Study Group.
  • Journal Title: Eur Respir J 32 Pages: 372-378
  • Peer Reviewed
• [Journal Article] Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease. (2008)
  • Author(s): Nagai K, Betsuyaku T, Suzuki M, Nasuhara Y, Kaga K, Kondo S, Nishimura M
  • Journal Title: Antioxid Redox Signal 10 Pages: 705-714
  • Peer Reviewed
• [Journal Article] Bronchiolar chemokine expression is different after single versus repeated cigarette smoke exposure. (2008)
  • Author(s): Betsuyaku T, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Adair-Kirk TL, Senior RM, Nishimura M
  • Journal Title: Respir Res 9 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients. (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Hata J, Takahashi H, Nishimura M
  • Journal Title: Inhal Toxicol 20 Pages: 349-359
  • Peer Reviewed
• [Journal Article] Functional SNPs of the CCL5 gene and non-emphysematous phenotype in patients with COPD. (2008)
  • Author(s): Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M; the Hokkaido COPD Cohort Study Group
  • Journal Title: Eur Respir J (In press)
  • Peer Reviewed
• [Journal Article] Beta2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD (2007)
  • Author(s): Hizawa N, Betsuyaku T, Itoh Y, Nagai K, Hasegawa M, Nasuhara Y, Nishimura M.
  • Journal Title: Chest,132 Pages: 1485-1492
  • Peer Reviewed
• [Journal Article] Lipopolysaccharide - induced neutrophilic inflammation in the lungs differs with age (2007)
  • Author(s): Ito Y, Betsuyaku T, Nasuhara Y, Nishimura M.
  • Journal Title: Exp Lung Res 33 Pages: 375-384
  • Peer Reviewed
• [Journal Article] Hokkaido COPD Cohort Study Group. : "Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease" (2007)
  • Author(s): Makita H, Nasuhara Y, Nagai K, Ito Y, Hasegawa M, Betsuyaku T, Onodera Y, Hizawa N, Nishimura M
  • Journal Title: Thorax 62 Pages: 932-937
  • Peer Reviewed
• [Journal Article] Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease (2007)
  • Author(s): Nagai K, Betsuyaku T, Suzuki M, Nasuhara Y, Kaga K, Kondo S, Nishimura M.
  • Journal Title: Antioxid Redox Signal 10 Pages: 705-714
• [Journal Article] Bronchiolar chemokine expression is different after single versus repeated cigarette smoke exposure (2007)
  • Author(s): Betsuyaku T, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Adair-Kirk TL, Senior RM, Nishimura M.
  • Journal Title: Respir Res 9 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients (2007)
  • Author(s): Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Hata J, Takahashi H, Nishimura M.
  • Journal Title: Inhal Toxicol 20 Pages: 349-359
  • Peer Reviewed
• [Journal Article] Beta2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD. (2007)
  • Author(s): Hizawa N, Betsuyaku T, Itoh Y, Nagai K, Hasegawa M, Nasuhara Y, Betsuyaku T, Itoh Y, Nagai K, Nishimura M,
  • Journal Title: Chest 132(5) Pages: 1485-1492
  • Peer Reviewed
• [Journal Article] Lipopolysaccharide-induced neutrophilic inflammation in the lungs differs with age. (2007)
  • Author(s): Ito Y, Betsuyaku T, Nasuhara Y, Nishimura M
  • Journal Title: Exp Lung Res 33(7) Pages: 375-384
  • Peer Reviewed
• [Journal Article] Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. (2007)
  • Author(s): Makita H, Nasuhara Y, Nagai K, Ito Y, Hasegawa M, Betsuyaku T, Onodera Y, Hizawa N, Nishimura M; Hokkaido COPD Cohort Study Group
  • Journal Title: Thorax 62 Pages: 932-793
  • Peer Reviewed
• [Journal Article] Curcumin attenuates elastase-and cigarette smoke-induced pulmonary emphysema in mice
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M
  • Journal Title: Am J Physiol Lung Cell Mol Physiol (in press)
  • Peer Reviewed
• [Journal Article] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergics in chronic obstructive pulmonary disease
  • Author(s): Hasegawa M, Makita H, Nasuhara Y, Nagai K, Ito Y, Odajima N, Betsuyaku T, Nishimura M
  • Journal Title: Thorax (in press)
  • Peer Reviewed
• [Presentation] Proteomic Analysis of Bronchoalveolar Lavage Fluid(BALF)from Subjects with Pulmonary Emphysema (2008)
  • Author(s): Suzuki M,Betsuyaku T, Nasuhara Y,Kaga K, Kondo S,Hamamura I, Adair-Kirk TL,Nguyet M,Nguyen,Senior RM, Nishimura M
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] アレルギー性気道炎症モデル及び喘息患者における気道被覆液中のカルボニル化蛋白の検討 (2008)
  • Author(s): 長井桂, 別役智子, 今野哲, 伊藤洋子, 南須原康行, 檜澤伸之, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] 線維化肺におけるcatalase発現の検討 (2008)
  • Author(s): 小田島奈央, 別役智子, 南須原康行, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] COPDの気流制限に及ぼす3次元CT画像で評価した気腫病変と気道病変の関与 (2008)
  • Author(s): 長谷川大, 南須原康行, 牧田比呂仁, 別役智子, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] 単回喫煙暴露マウスモデルでの好中球性炎症および細気管支上皮のケモカイン産生におよぼす加齢の影響 (2008)
  • Author(s): 守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] 臨床安定期の中・高年気管支喘息患者における気流制限と肺CT3次元気道解析でみた気道病変との関係 (2008)
  • Author(s): 清水薫子, 南須原康行, 長谷川大, 牧田比呂仁, 今野哲, 別役智子, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] Proteomic Analysis of Bronchoalveolar Lavage Fluid (BALF) from Subjects with Pulmonary Emphysema (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara N, Kaga K, Kondo S, Hamamura I, Adair-Kirk TL, Nguyet M. Nguyen, Senior RM, Nishimura M
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] Progressive Infiltration of Lymphocytes and Upregulation of MIP-3alpha/CCL20 after Cessation of Cigarette Smoke(CS)Exposure in Aged Mice (2008)
  • Author(s): Betsuyaku T, Moriyama C, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aging Affects Lipopolysaccaride(LPS)-Induced Upregulation of Heme Oxygenase-1(HO-1)in the Lungs and Alveolar Macrophages(Ams) (2008)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Eosinophils Mediate Albumin Carbonylation in the Epithelial Lining Fluid during Allergic Airway Inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Contribution of Airway Disease and Emphysema to Airflow Limitation in Chronic Obstructive Pulmonary Disease(COPD)Assessed by Three-dimensional Computed Tomography (2008)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Betsuyaku T, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Decreased Catalase Expression in Bronchiolization and Squamous Metaplasia in Lung Fibrosis (2008)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Laminins alpha5 and gamma2 and VEGF Are Down-Regulated in Lung in Cigarette Smoke(CS)-Exposed Mice and Emphysema Subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk T, Nguyen NM, Senior RM, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aged Mice Exhibit Enhanced Expression of Chemokines in Bronchiolar Epithelium and Rapid Neutrophil Accumulation in Response to Single Cigarette Smoke(CS)Exposure (2008)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Relationship between airflow limitation and wall area, airway luminal area measured by three-dimensional computed tomography in bronchial asthma (2008)
  • Author(s): Shimizu K, Nasuhara Y, Hasegawa M, Makita H, Konno S, Betsuyaku T, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Proteomic Analysis of Bronchoalveolar Lavage Fluid(BALF)from Subjects with Pulmonary Emphysema (2008)
  • Author(s): Hayashi M, Yamagata A, Oofusa K, Takada T, Betsuyaku T, Nishimura M, Nakata K
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Progressive Infiltration of Lymphocytes and Upregulation of MIP-3alpha / CCL20 after Cessation of Cigarette Smoke (CS) Exposure in Aged Mice (2008)
  • Author(s): Betsuyaku T, Moriyama C, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aging Affects Lipopolysaccaride (LPS)-Induced Upregulation of Heme Oxygenase-1 (HO-1) in the Lungs and Alveolar Macrophages (AMs) (2008)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Eosinophils Mediate Albumin Carbonylation in the Epithelial Lining Fluid during Allergic Airway Inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Contribution of Airway Disease and Emphysema to Airflow Limitation in Chronic Obstructive Pulmonary Disease (COPD) Assessed by Three-dimensional Computed Tomography (2008)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Betsuyaku T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Decreased Catalase Expression in Bronchiolization and Squamous Metaplasia in Lung Fibrosis (2008)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Laminins alpha5 and gamma2 and VEGF Are Down-Regulated in Lung in Cigarette Smoke (CS)-Exposed Mice and Emphysema Subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara M, Kaga K, Kondo S, Hamamura I, Adair-Kirk T,Nguyen NM, Senior RM, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aged Mice Exhibit Enhanced Expression of Chemokines in Bronchiolar Epithelium and Rapid Neutrophil Accumulation in Response to Single Cigarette Smoke (CS) Exposure (2008)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, J. Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Relationship between airflow limitation and wall area, airway luminal area measured by three-dimensional computed tomography in bronchial asthma (2008)
  • Author(s): Shimizu K, Nasuhara Y, Hasegawa M, Makita H, Konno S, Betsuyaku T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Proteomic Analysis of Bronchoalveolar Lavage Fluid (BALF) from Subjects with Pulmonary Emphysema (2008)
  • Author(s): Hayashi M, Yamagata A, Oofusa K, Takada T, Betsuyaku T, Nishimura M, Nakata K
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Catalase mRNA expression in bronchiolar epithelium in mice is up-regulated by acute cigarette smoke(CS)exposure and down-regulated by chronic CS exposure (2007)
  • Author(s): Betsuyaku T, Hamamura I, Hata J, Mitsuhashi H, Adair-Kirk TL, Griffin GL, Senior RM, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] Relationship of Emphysema with Airway Dimensions in Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Onodera Y, Betsuyaku T, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] Impaired Cigarette Smoke Extract(CSE)-induced Upregulation of Heme Oxigenase-1(HO-1)in Alveolar Macrophages(AMs)but not in Peritoneal Macrophages(PMs)in Aged Mice (2007)
  • Author(s): Ito Y, Betsuyaku T, Nagai K, Suzuki M, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] Diverse Expression of Phosphatidylserine Receptor(PSR)and Vitronectin Receptor(VnR)in Monocytic Cell Lineage and Alveolar Macrophages(Ams)in Smokers (2007)
  • Author(s): Ito Y, Betsuyaku T, Nagai K, Suzuki M, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] Aged mice exhibit enhanced neutrophilic inflammation after short-term cigarette smoke(CS)exposure (2007)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Mitsuhashi H,Nasuhara Y,Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] Dual function NADPH oxidase/heme peroxidase(Duox)1 and 2 Expression in Airway Epithelium in Smokers and Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): Nagai K, Betsuyaku T, Suzuki M, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] Increase of Sputum Protein Carbonyls as an Oxidative Stress Marker in Asthma (2007)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] NF-E2-related factor 2(Nrf2)expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients (2007)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] Matrix Metalloproteinase Inducer(EMMPRIN)is Highly Expressed in Lymphangioleiomyomatosis(LAM) (2007)
  • Author(s): Odajima N, Bestuyaku T, Suzuki M, Hosokawa T, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-18
• [Presentation] Catalase mRNA expression in bronchiolar epithelium in mice is up-regulated by acute cigarette smoke(CS)exposure and down-regulated by chronic CS exposure (2007)
  • Author(s): Betsuyaku T, Hamamura I, Hata J, Mitsuhashi H, Adair-Kirk TL, Griffin GL, Senior RM, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] Relationship of Emphysema with Airway Dimensions in Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Onodera Y, Betsuyaku T, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] Impaired Cigarette Smoke Extract(CSE)-induced Upregulation of Heme Oxigenase-1(HO-1)in Alveolar Macrophages(AMs)but not in Peritoneal Macrophages(PMs)in Aged Mice (2007)
  • Author(s): Ito Y, Betsuyaku T, Nagai K, Suzuki M, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] Diverse Expression of Phosphatidylserine Receptor(PSR)and Vitronectin Receptor(VnR)in Monocytic Cell Lineage and Alveolar Macrophages(AMs)in Smokers (2007)
  • Author(s): Ito Y, Betsuyaku T, Nagai K, Suzuki M, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] Aged mice exhibit enhanced neutrophilic inflammation after short-term cigarette smoke(CS)exposure (2007)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] Dual function NADPH oxidase/heme peroxidase(Duox)1 and 2 Expression in Airway Epithelium in Smokers and Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): Nagai K, Betsuyaku T, Suzuki M, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] Increase of Sputum Protein Carbonyls as an Oxidative Stress Marker in Asthma (2007)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] NF-E2-related factor 2(Nrf2)expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)pat (2007)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] Extracellular Matrix Metalloproteinase Inducer(EMMPRIN)is Highly Expressed in Lymphangioleiomyomatosis(LAM) (2007)
  • Author(s): Odajima N, Bestuyaku T, Suzuki M, Hosokawa T, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco USA
  • Year and Date: 2007-05-18
• [Presentation] Impaired Cigarette Smoke Extract-induced Upregulation of Heme Oxigenase-1(HO-1)in Alveolar Macrophages but not in Peritoneal Macrophages in Aged Mice (2007)
  • Author(s): 伊藤洋子, 別役智子, 長井桂, 鈴木雅, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-10
• [Presentation] NF-E2-related factor 2(Nrf2)expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients (2007)
  • Author(s): 鈴木雅, 別役智子, 伊藤洋子, 長井桂, 南須原康行, 加賀基地三, 近藤哲, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-10
• [Presentation] Dual function NADPH oxidase/heme peroxidase(Duox)1 and 2 Expression in Airway Epithelium in Smokers and Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): 長井桂, 別役智子, 鈴木雅, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-10
• [Presentation] Relationship of Emphysema with Airway Dimensions in Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): 長谷川大, 南須原康行, 牧田比呂仁, 小野寺祐也, 別役智子, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 第47回日本呼吸器学会学術講演会
  • Year and Date: 2007-05-10
• [Presentation] 短期喫煙暴露モデルにおける好中球性炎症に対する加齢の影響 (2007)
  • Author(s): 守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-10
• [Presentation] Impaired Cigarette Smoke Extract-induced Upregulation of Heme Oxigenase-1(HO-1)in Alveolar Macrophages but not in Peritoneal Macrophages in Aged Mice (2007)
  • Author(s): 伊藤洋子, 別役智子, 長井 桂, 鈴木 雅, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム,東京
  • Year and Date: 2007-05-10
• [Presentation] NF-E2-related factor 2(Nrf2)expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients (2007)
  • Author(s): 鈴木 雅, 別役智子, 伊藤洋子, 長井 桂, 南須原康行, 加賀基地三, 近藤 哲, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム,東京
  • Year and Date: 2007-05-10
• [Presentation] Dual function NADPH oxidase/heme peroxidase(Duox)1 and 2 Expression in Airway Epithelium in Smokers and Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): 長井 桂, 別役智子, 鈴木 雅, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム,東京
  • Year and Date: 2007-05-10
• [Presentation] Relationship of Emphysema with Airway Dimensions in Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): 長谷川 大, 南須原康行, 牧田比呂仁, 小野寺祐也, 別役智子, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム,東京
  • Year and Date: 2007-05-10
• [Presentation] 短期喫煙暴露モデルにおける好中球性炎症に対する加齢の影響 (2007)
  • Author(s): 守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム,東京
  • Year and Date: 2007-05-10
• [Presentation] Lymphangioleiomyomatosis(LAM)におけるExtracellular Matrix Metalloproteinase(EMMPRIN)発現の検討 (2007)
  • Author(s): 小田島奈央, 別役智子, 鈴木雅, 細川剛, 南須原康行, 西村正治
  • Organizer: 第104回日本内科学会
  • Place of Presentation: 大阪 : 大阪国際会議場
  • Year and Date: 2007-04-03
• [Presentation] Lymphangioleiomyomatosis(LAM)におけるExtracellular Matrix Metalloproteinase(EMMPRIN)発現の検討 (2007)
  • Author(s): 小田島奈央, 別役智子, 鈴木 雅, 細川 剛, 南須原康行, 西村正治
  • Organizer: 第104回日本内科学会
  • Place of Presentation: 大阪国際会議場,大阪
  • Year and Date: 2007-04-03