Relevance of near UV to the development of skin cancer

• Project/Area Number: 19390296
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kobe University
• Principal Investigator: NISHIGORI Chikako Kobe University, 大学院・医学研究科, 教授 (50198454)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2007: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
• Keywords: ピリミジンダイマー / 皮膚がん / メラノーマ / 8-ヒドロキシグアニン / 長波長紫外線 / 光発がん / 皮膚癌 / 8ヒドロキシグアニン

Research Abstract

紫外線の波長特異的な生物学効果とリスクの検証のために, 二つの実験を行った。NB-UVBとBB-UVBの長期、継続的照射試験による発がん性の検討を行なったところ、ナローバンドUVB照射群マウスにおいてブロードバンドのそれと比較して有意に皮膚腫瘍の悪性化率の上昇を認め、その原因としてNB-UVBがCyclobutaine pirimidine dimersをより多く形成していることが示唆された。長波長紫外線としてUVA領域の 364nmレーザーを用いて1MJ/m2のUVA領域の照射を行ったところ、酸化型DNA損傷のみでなく、ピリミジンダイマーも生じることが明らかになった。おそらく内因性の光増感物質の関与があると思われるが、この事実はヒトにおける皮膚癌発症を考える上で重要である。

Research Products

• [Journal Article] Antiproliferative activity of IL-27 on melanoma (2008)
  • Author(s): Yoshimoto T, Morishima N, Mizuguchi I, Shimizu M, Nagai H, Oniki S, Oka M, Nishigori C, Mizuguchi J
  • Journal Title: J Immunol 180 Pages: 6527-6535
  • Peer Reviewed
• [Journal Article] Four types of possible founder mutations are responsible for 87% of Japanese patients with Xeroderma pigmentosum variant type (2008)
  • Author(s): Masaki T, Ono R, Tanioka M, Funasaka Y, Nagano T, Moriwaki S, Nishigori C
  • Journal Title: J Dermatol Sci 52 Pages: 144-148
  • NAID: 10024457638
  • Peer Reviewed
• [Journal Article] Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma (2008)
  • Author(s): Ohtani Y, Harada T, Funasaka Y, Nakao K, Takahara C, Abdel-Daim M, Sakai N, Saito N, Nishigori C, Aiba A
  • Journal Title: Oncogene 27 Pages: 7162-7170
  • Peer Reviewed
• [Journal Article] Involvement of interleukin-10 promoter polymorphism in non-melanoma skin cancers-A case study in non-carcinoma skin cancer patients (2008)
  • Author(s): Nagano T, Kunisada M, Yu X, Masaki T, Nishigori C
  • Journal Title: Photochem Photobiol 84 Pages: 63-66
  • Peer Reviewed
• [Journal Article] In vitro expansion of immature melanoblasts and their ability to repopulate melanocyte stem cells in the hair follicle (2008)
  • Author(s): Yonetani S, Osawa M, Moriyama M, Maku S, Nishigori C, Nishikawa S
  • Journal Title: J Invest Dermatol 128 Pages: 408-420
  • Peer Reviewed
• [Journal Article] エビデンスに基づいたUVB療法-安全性と有効性のバランス- (2008)
  • Author(s): 錦織千佳子
  • Journal Title: 日本皮膚科学会誌(増) 118 Pages: 2768-2872
  • NAID: 10025378815
• [Journal Article] Anti-proliferative activity of IL-27 on melanoma. (2008)
  • Author(s): Yoshimoto T
  • Journal Title: J Immunol 180 Pages: 6527-6535
  • Peer Reviewed
• [Journal Article] Four types of possible founder mutations are responsible for 87% of Japanese patients with Xeroderma pigmentosum variant type. (2008)
  • Author(s): Masaki T
  • Journal Title: J Dermatol Sci 52 Pages: 144-148
  • Peer Reviewed
• [Journal Article] Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma. (2008)
  • Author(s): Ohtani Y
  • Journal Title: Oncogene 27 Pages: 7162-7170
  • Peer Reviewed
• [Journal Article] Involvement of interleukin-10 promoter polymorphism in non-melanoma skin cancers -A case study in non-carcinoma skin cancer patients. (2008)
  • Author(s): Nagano T
  • Journal Title: Photochem Photobiol 84 Pages: 63-66
  • Peer Reviewed
• [Journal Article] 紫外線発癌 (2007)
  • Author(s): 錦織千佳子
  • Journal Title: 日本皮膚科学会誌 117(増) Pages: 2201-2203
  • NAID: 10020565897
• [Journal Article] Narrow-band UVB induced more carcinogenic skin tumors than broadband UVB through the formation of cyclobutane pyrimidine dimmer (2007)
  • Author(s): Kunisada M, Kumimoto H, Ishizaki K, Sakumi K, Nakabeppu Y, Nishigori C
  • Journal Title: J Invest Dermatol 127 Pages: 2865-2871
  • Peer Reviewed
• [Journal Article] 「皮膚科セミナリウム」高発癌性皮膚疾患 : 遺伝と皮膚癌色素性乾皮症 (2007)
  • Author(s): 錦織千佳子
  • Journal Title: 日本皮膚科学会誌 117 Pages: 15-22
• [Journal Article] Molecular analysis of DNA polymerase eta gene in Japanese patients diagnosed as xeroderma pigmentosum variant type (2007)
  • Author(s): Tanioka M, Masaki T, Ono R, Nagano T, Otoshi-Honda E, Matsumura Y, Takigawa M, Inui T, Miyachi Y, Moriwaki S, Nishigori C
  • Journal Title: J Invest Dermatol 127 Pages: 1745-1751
  • Peer Reviewed
• [Journal Article] Narrow-band UVB induced more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer. (2007)
  • Author(s): Kunisada M
  • Journal Title: J Invest Dermatol 127 Pages: 2865-2871
  • Peer Reviewed
• [Journal Article] Molecular analysis of DNA polymerase eta gene in Japanese patients diagnosed as xeroderma pigmentosum variant type. (2007)
  • Author(s): Tanioka M
  • Journal Title: J Invest Dermatol 127 Pages: 1745-1751
  • Peer Reviewed
• [Presentation] Crucial role of phospholipase Cε in ultraviolet B irradiation-induced skin inflammation and skin tumor development (2008)
  • Author(s): Oka M, Kamo T, Edamatsu H, Kunisada M, Kataoka T, Nishigori C
  • Organizer: 34th Meeting of the American Society for Photobiology
  • Place of Presentation: Burlingame, CA, USA
• [Presentation] Crucial role of phospholipase C ε in ultraviolet B irradiation-inducedskin inflammation and skin tumor development. (2008)
  • Author(s): Oka M
  • Organizer: 34th Meeting of the American Society for Photobiology
  • Place of Presentation: Burlingame, CA, USA
• [Presentation] Relevance to the UV wavelength in carcinogenesis (2007)
  • Author(s): Nishigori C
  • Organizer: 21th World Congress of Dermatology
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Relevance to the UV wavelength in carcinogenesis. (2007)
  • Author(s): Nishigori C
  • Organizer: 21th World Congress of Dermatology
  • Place of Presentation: Buenos Aires, Argentina
• [Book] 皮膚科サブスペシャリティーシリーズ1冊でわかる光皮膚科-皮膚科医に必須のphotodermatology- (2008)
  • Author(s): 錦織千佳子
  • Publisher: 文光堂
• [Book] 図説分子病態学4版 (2008)
  • Author(s): 錦織千佳子
  • Publisher: 中外医学社
• [Book] 皮膚科サブスペシャリティーシリーズ1冊でわかる光皮膚科 皮膚科医に必須のphotodermatology (2008)
  • Author(s): 錦織 千佳子
  • Publisher: 文光堂
• [Book] 皮膚科診療プラクティス20 Environmental Dermatology環境・職業からみた皮膚疾患 (2007)
  • Author(s): 錦織千佳子
  • Publisher: 文光堂
• [Book] Environmental Dermatology:環境・職業からみた皮膚疾患 (2007)
  • Author(s): 錦織千佳子
  • Publisher: 文光堂