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Disorder of reward circuit in bipolar disorders : integration of basic and clinical investigation

Research Project

Project/Area Number 19390306
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

KANBA Shigenobu  Kyushu University, 大学院・医学研究院, 教授 (50195187)

Co-Investigator(Kenkyū-buntansha) NAKABEPPU Yusaku  九州大学, 生体防御医学研究所, 教授 (30180350)
KUROKI Toshihide  九州大学, 大学院・医学研究院, 准教授 (60215093)
KAWASAKI Hiroaki  九州大学, 大学院・医学研究院, 准教授 (50224762)
ONITSUKA Toshiaki  九州大学, 大学病院, 講師 (00398059)
MAEKAWA Toshihiko  九州大学, 大学病院, 助教 (40448436)
MOTOMURA Keisuke  九州大学, 大学病院, 助教 (60432944)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords精神薬理学 / 双極性障害 / 扁桃体 / 分界条床核 / ミクログリア / サイトカイン / 一酸化窒素 / グルタミン酸 / 聴覚ミスマッチ陰性反応 / c-Fos / アデノシン受容体
Research Abstract

Auditory evoked potential and mismatch negativity are less impaired in bipolar disorder as compared with schizophrenia. However, impairment was not statistically significant from healthy volunteers. These markers may differential bipolar disorder from schizophrenia. In addition, polymorphism of serotonin transporter genes is associated with bipolar disorder. In animal study, when given stress ; psychological or immunological, particular circuits are stimulated including hypothalamus, frontal cortex, and limbic reward system regardless the kinds of stimuli.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (49 results)

All 2009 2008 2007 Other

All Journal Article (22 results) (of which Peer Reviewed: 11 results) Presentation (16 results) Book (9 results) Remarks (2 results)

  • [Journal Article] Auditory gating deficit to human voices in schizophrenia: A MEG study.2009

    • Author(s)
      Hirano Y, Hirano S, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T
    • Journal Title

      Schizophrenia Research 117(1)

      Pages: 61-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Preattentive visual change detection as reflected by the mismatch negativity (MMN)-evidence for a memory-based process.2009

    • Author(s)
      Maekawa T, Tobimatsu S, Ogata K, Onitsuka T, Kanba S.
    • Journal Title

      Neuroscience Research 65(1)

      Pages: 107-12

    • NAID

      10027500613

    • Related Report
      2009 Final Research Report
  • [Journal Article] Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia.2009

    • Author(s)
      Mizoguchi Y, Monji A, Kato T, Seki Y, Gotoh L, Horikawa H, Suzuki SO, Iwaki T, Yonaha M, Hashioka S, Kanba S.
    • Journal Title

      Journal of Immunology 183(12)

      Pages: 7778-86

    • Related Report
      2009 Final Research Report
  • [Journal Article] Anti-Inflammatory effects of antidepressants : possibilities for preventives against Alzheimer's disease.2009

    • Author(s)
      Hashioka S, et al
    • Journal Title

      Central Nervous System Agents in Medicinal Chemistry 9

      Pages: 12-19

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytokines and schizophrenia : microglial hypothesis of schizophrenia.2009

    • Author(s)
      Monji A, et al
    • Journal Title

      Psychiatry and Clinical Neurosciences 63

      Pages: 257-265

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor(BDNF)induces sustained elevation of intracellular Ca2+ in rodent microglia.2009

    • Author(s)
      Mizoguchi Y, et al
    • Journal Title

      J Immunology 183

      Pages: 7778-86

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased spatial frequency sensitivities for processing faces in male patients with chronic schizophrenia.2009

    • Author(s)
      Obayashi C, et al
    • Journal Title

      Clin Neurophysiology 120

      Pages: 1525-1533

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal Visual N170 Modulation in Response to Spatial Frequency Changes in Male Patients with Chronic Schizophrenia2009

    • Author(s)
      Choji Obayashi, et al.
    • Journal Title

      Schizophrenia Research (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal neural oscillatory activity to speech sounds in schizophrenia: a MEG study.2008

    • Author(s)
      Hirano S, Hirano Y, Maekawa T, Obayashi C, Oribe N, Kuroki T, Kanba S, Onitsuka T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 4897-903

    • Related Report
      2009 Final Research Report
  • [Journal Article] Inhibitory effects of aripiprazole on interferon-γ-inducedmicroglial activation via intracellular Ca2+ regulation in Vitro.2008

    • Author(s)
      Takahiro Kato, Yoshito Mizoguchi, Akira Monji, Hideki Horikawa, Sadayuki Hashioka, Shigenobu Kanba
    • Journal Title

      Journal of Neurochemistry 106

      Pages: 815-25

    • Related Report
      2009 Final Research Report
  • [Journal Article] Auditory sensory gating to the human voice: A preliminary MEG study.2008

    • Author(s)
      Hirano Y, Onitsuka T, Kuroki T, Matsuki Y, Hirano S, Maekawa T, Kanba S
    • Journal Title

      Psychiatry Research 163

      Pages: 260-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma.2008

    • Author(s)
      Bian Q, Kato T, Monji A, Hashioka S, Mizoguchi Y, Horikawa H, Kanba S.
    • Journal Title

      Progress in Neuropsychopharmacol and Biological Psychiatry 32

      Pages: 42-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] Auditory sensory gating to human voice: a preliminary MEG study.2008

    • Author(s)
      Yoji Hirano, et al.
    • Journal Title

      Psychiatry Research Neuroimaging 163

      Pages: 260-269

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal neural oscillatory activity to speech sounds in schizophrenia: aMEG study.2008

    • Author(s)
      Shogo Hirano, et al.
    • Journal Title

      J Neuroscience 28

      Pages: 4897-4903

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of aripiprazole on interferon-γ-inducedmicroglial activation via intracellular Ca2+ regulation in Vitro.2008

    • Author(s)
      Takahiro Kato, et al.
    • Journal Title

      Journal of Neurochemistry 106

      Pages: 815-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory sensory gating to human voice:a preliminary MEG study2008

    • Author(s)
      Yoji Hirano, et. al.
    • Journal Title

      Psychiatry Research Neuroimaging (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal neural oscillatory activity to speech sounds in schizophrenia:aMEG study.2008

    • Author(s)
      Shogo Hirano, et. al.
    • Journal Title

      J Neuroscience (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antidepressant inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide.2007

    • Author(s)
      Hashioka S. Klegeris A, Monji A. kato T. Sawada M. McGeer PL. Kanba S
    • Journal Title

      Expermental Neurology 206(1)

      Pages: 33-42

    • Related Report
      2009 Final Research Report
  • [Journal Article] Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia.2007

    • Author(s)
      Hashioka S. Han YH. Fujii S. Kato T. Monji A. Utsumi H. Sawada M. Nakanishi H. Kanba S
    • Journal Title

      Neurochemistry International 50

      Pages: 499-506

    • Related Report
      2009 Final Research Report
  • [Journal Article] Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro.2007

    • Author(s)
      Kato T. Monji A. Hashioka S. Kanba S
    • Journal Title

      Schizophrenia Research 92

      Pages: 108-115

    • Related Report
      2009 Final Research Report
  • [Journal Article] A neurotoxic dose of methamphetamine induces gene expression of Homer 1a, but not Homer 1b or 1c, in the striatum and nucleus accumbens.2007

    • Author(s)
      Hashimoto K, Nakahara T, Yamada H, Hirano M, Kuroki T, Kanba S
    • Journal Title

      Neurochem Int. 51(2-4)

      Pages: 227-32

    • Related Report
      2009 Final Research Report
  • [Journal Article] Genetic structure of the dopamine receptor D4 gene(DRD4)and lack of association with schizophrenia in Japanese patients2007

    • Author(s)
      Mitsuyasu H, Kawasaki H, Ninomiya H, Kinukawa N, Yamanaka T, Tahira T, Stanton VP Jr, Springett GM, Hayashi K, Tashiro N, Kanba S.
    • Journal Title

      J Psychiatr Research 41

      Pages: 763-775

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Association analysis of adenosine A1 receptor and dopamine D1 receptor genes with schizophrenia in the Japanese population. American Society of Human Genetics 2007 San Diago 2. Monji A et al.2009

    • Author(s)
      Gotoh L, Kawasaki H, Mitsuyasu H, et al.
    • Organizer
      Are atypical antipsychotics fire extinguishers in the brain? World Congress of Biological Psychiatry
    • Place of Presentation
      Paris
    • Related Report
      2009 Final Research Report
  • [Presentation] Deficit in theory of mind predicts treatment outcome of depression2009

    • Author(s)
      Kanba S, et al
    • Organizer
      World Congress of Biological Psychiatry
    • Place of Presentation
      パリ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Are atypical antipsychotics fire extinguishers in the brain?2009

    • Author(s)
      Monji A, et al
    • Organizer
      World Congress of Biological Psychiatry
    • Place of Presentation
      パリ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Possible roles of BDNF-induced microglia intracellular Ca elevation in the pathophysiology of psychiatric disorders2009

    • Author(s)
      Mizoguchi Y, et al
    • Organizer
      World Congress of Biological Psychiatry
    • Place of Presentation
      パリ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Corticotropin-releasing factor receptor 1 antagonist attenuates neurochemical responses against swim stress in the rodent brain2009

    • Author(s)
      Ohashi A, et al
    • Organizer
      World Congress of Biological Psychiatry
    • Place of Presentation
      パリ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural Oscillatory activity to speech sounds in bipolar disorder2009

    • Author(s)
      Orive N, et al
    • Organizer
      World Congress of Biological Psychiatry
    • Place of Presentation
      パリ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Auditory sensory gating deficit to voices in patients with psychotic bipolar disorder : A WEG study2009

    • Author(s)
      Hirano Y, et al
    • Organizer
      World Congress of Biological Psychiatry
    • Place of Presentation
      パリ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Altered visual attentional system in schizophrenia : Evidence from an ERP study.2008

    • Author(s)
      Maekawa T, Hirano Y, Hirano S, Obayashi C, Onitsuka T, Tobimatsu S, Kanba S
    • Organizer
      63^<rd> Annual Scientific Convention & Meeting of Society of Biological Psychiatry
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Auditory sensory gating deficit to voice in schizophrenia : an MEG study.2008

    • Author(s)
      Hirano Y, Onitsuka T, Hirano S, Maekawa T, Obayashi C, Oribe N, Kanba S
    • Organizer
      63^<rd> Annual Scientific Convention & Meeting of Society of Biological Psvchiatrv
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Abnormal N170 modulation in frequency change in male patients with chronic schizophrenia.2008

    • Author(s)
      Obayashi C, Nakashima T, Maekawa T, Hirano Y, Hirano S, Oribe N, Tobimatsu S, Kanba S, Onitsuka T
    • Organizer
      63^<rd> Annual Scientific Convention & Meeting of Society of Biological Psychiatry
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Serotonin transporter polymorphism in Japanese patients with bipolardisorder2007

    • Author(s)
      Naoya ORIBE, Hiroaki KAWASAKI, Hiroshi MITSUYASU, Yuki KOBAYASHI, Leo GOTOH, Atsushi TAKATA, Shigenobu KANBA
    • Organizer
      The American Society of Human Genetics 2007 Annual Meeting
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic analysis of the human striatum-enriched CalDAG-GEFI gene with Japanese schizophrenia patients2007

    • Author(s)
      Hiroshi MITSUYASU, Hiroaki KAWASAKI, Yuki KOBAYASHI, Leo GOTOH, Naoya DRIBE, Atsushi TAKATA, Shigenobu KANBA
    • Organizer
      The American Society of Human Genetics 2007 Annual Meeting
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Association Analysis of Adenosine A1 receptor(ADOIZA1)and Dopamine D1 receptor(DRD1)genes with schizophrenia in the Japanese population2007

    • Author(s)
      Leo GOTOH, Hiroaki KAWASAKI, Hiroshi MITSUYASU, Yuki KOBAYASHI, Naoya ORIBE, Atsushi TAKATA, Shigenobu KANBA
    • Organizer
      The American Society of Human Genetics 2007 Annual Meeting
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Association Study of Diacylglycerol Kinase Eta(DGKH)Gene with Bipolar Disorder Patients in Japanese Population and Biological Function Analysis of DGKH Isoform 2 Va11201Ala Polymorphism2007

    • Author(s)
      Atsushi TAKATA, Hiroaki KAWASAKI, Hiroshi MITSUYASU, Yuki KOBAYASHI, Leo GOTOH, Naoya ORIBE, Shigenobu KANBA
    • Organizer
      The American Society of Human Genetics 2007 Annual Meeting
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Association analysis of human CAMP-GEFII gene polymorphisms with Japanese schizophrenia patients2007

    • Author(s)
      Hiroaki KAWASAKI, Hiroshi MITSUYASU, Yuki KOBAYASHI, Leo GOTOH, Naoya DRIBE, Atsushi TAKATA, Shigenobu KANBA
    • Organizer
      The American Society of Human Genetics 2007 Annual Meeting
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clinical Research Activities on Bipolar disorder in Japan2007

    • Author(s)
      Hiroaki Kawasaki, Naoya Oribe, Shieenobu Kanha
    • Organizer
      First World Congress of Asian Psychiatry, world psychiatric association
    • Place of Presentation
      インド・ゴア
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Book] 現代うつ病の臨床2009

    • Author(s)
      神庭重信、黒木俊秀
    • Total Pages
      318
    • Publisher
      創元社
    • Related Report
      2009 Annual Research Report
  • [Book] 精神疾患の脳画像解析・診断学2008

    • Author(s)
      鬼塚俊明
    • Total Pages
      8
    • Publisher
      南山堂
    • Related Report
      2008 Annual Research Report
  • [Book] 精神疾患と脳画像2008

    • Author(s)
      鬼塚俊明, 重藤寛史
    • Total Pages
      18
    • Publisher
      中山書店
    • Related Report
      2008 Annual Research Report
  • [Book] Bipolar Disorder2008

    • Author(s)
      織部直弥, 後藤玲央, 高田篤, 平野昭吾, 平野羊嗣, 前川敏彦, 鬼塚俊明, 川寄弘詔, 神庭重信
    • Total Pages
      7
    • Publisher
      アルタ出版
    • Related Report
      2008 Annual Research Report
  • [Book] 気分障害:気分障害の病因2008

    • Author(s)
      川嵜 弘詔、織部 直弥、神庭 重信
    • Total Pages
      6
    • Publisher
      医学書院
    • Related Report
      2007 Annual Research Report
  • [Book] MEG脳磁図2007

    • Author(s)
      鬼塚俊明
    • Publisher
      先端医学社
    • Related Report
      2009 Final Research Report
  • [Book] MEG(脳磁図)2007

    • Author(s)
      鬼塚 俊明
    • Total Pages
      2
    • Publisher
      先端医学社
    • Related Report
      2007 Annual Research Report
  • [Book] 統合失調症関連遺伝子.TEXT精神医学改定3版2007

    • Author(s)
      川嵜 弘詔
    • Total Pages
      2
    • Publisher
      株式会社南山堂
    • Related Report
      2007 Annual Research Report
  • [Book] KEY WORD精神第4版STEP-BD2007

    • Author(s)
      川嵜 弘詔、織部 直弥、神庭 重信
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • Related Report
      2009 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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