Role of glycosylation in the oncogenesis of gastrointestinal sarcoma
| Project/Area Number |
19390349
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIDA Toshiro Osaka University, 医学系研究科, 准教授 (40263264)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Eui 大阪大学, 医学系研究科, 教授 (20322183)
廣田 誠一 兵庫医科大学, 医学部, 教授 (50218856)
仲 哲治 独立行政法人医薬基盤研究所, 基盤的研究部, プロジェクトリーダー (30303936)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROTA Seiichi 兵庫医科大学, 医学部, 教授 (50218856)
NAKA Tetuji 独立行政法人医療基盤研究所, 基盤的研究部, プロジェクトリーダー (30303936)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 糖鎖修飾 / 消化管間質腫瘍 / KITチロシンキナーゼ / 遺伝子変異 / マイクロアレイ / プロテオーム解析 / GIST |
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| Research Abstract |
Many juvenile gastrointestinal stromal tumors (GIST) lack either mutation and are considered to develop with a different pathogenesis. Although, SDS-PAGE gels showed that there was a difference of each KIT bands between adult and juvenile GIST, they became the same after removal of N-glycans or sialic acids. Moreover, one of the most typical enzymes, ST6Gal1, which transfers Neu5Ac residues in a2-6 linkage to Gal b1-4GlcNAc units on N-glycans, is significantly less expressed in juvenile GIST. This suggests that the difference in KIT is generated by post-translational modification and may play a role in the progression of juvenile GIST.
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Report
(4 results)
Research Products
(103 results)
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[Journal Article] Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus.2009
Author(s)
Makino T, Yamasaki M, Takeno A, Shirakawa M, Miyata H, Takiguchi S, Nakajima K, Fujiwara Y, Nishida T, Matsuura N, Mori M, Doki Y.
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Journal Title
Br J Cancer 101(8)
Pages: 1298-306
Related Report
Peer Reviewed
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[Journal Article] Partial gastrectomy using natural orifice translumenal endoscopic surgery (NOTES) for gastric submucosal tumors: early experience in humans.2009
Author(s)
Nakajima K, Nishida T, Takahashi T, Souma Y, Hara J, Yamada T, Yoshio T, Tsutsui T, Yokoi T, Mori M, Doki Y.
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Journal Title
Surg Endosc 23
Pages: 2650-2655
Related Report
Peer Reviewed
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[Journal Article] Adjuvant treatment of GIST with imatinib: Solid ground or still quicksand? A comment on behalf of the EORTC Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group, the NCRI Sarcoma Clinical Studies Group (UK), the Japanese Study Group on GIST, the Adjuvant treatment of GIST with imatinib: Solid ground or2009
Author(s)
Gronchi A, Judson I, Nishida T, Poveda A, Martin J, Reichardt P, Casali PG, Cesne AL, Hohenberger P, Blay JY
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Journal Title
Eur J Cancer 45(7)
Pages: 1103-6
Related Report
Peer Reviewed
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[Journal Article] Aberrant Expression of Glycosylation in Juvenile Gastrointestinal Stromal Tumors.2008
Author(s)
Takahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T.
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Journal Title
Proteomics Clinical Applications 2
Pages: 1246-1254
Related Report
Peer Reviewed
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[Journal Article] Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal GIST.2007
Author(s)
Kinoshita K, Hirota S, Isozaki K, Nishitani A, Tsutsui S, Watabe K, Tamura S, Ishikawa T, Kanda T, Nishida T, Hayashi N
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Journal Title
Am J Gastroenterol 102(5)
Pages: 1134-1136
Related Report
Peer Reviewed
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[Journal Article] Proteomics-based identification of alpha-enolase as a tumor antigen in non-small lung cancer.2007
Author(s)
He P, Naka T, Serada S, Fujimoto M, Tanaka T, Hashimoto S, Shima Y, Yamadori T, Suzuki H, Hirashima T, Matsui K, Shiono H, Okumura M, Nishida T, Tachibana I, Norioka N, Norioka S, Kawase I
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Journal Title
Cancer Sci 98(8)
Pages: 1234-1240
NAID
Related Report
Peer Reviewed
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