Development of genetic diagnosis and drugs for lung cancer, based on protein phosphatase targeting
| Project/Area Number |
19390370
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Miyagi Cancer Center Research Institute |
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Principal Investigator |
SATO Masami Miyagi Cancer Center Research Institute, 薬物療法学部, 特任研究員 (30250830)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMA Hiroshi 宮城県立がんセンター研究所, 薬物療法学部, 部長 (10196462)
TANUMA Nobuhiro 宮城県立がんセンター研究所, 薬物療法学部, 研究員 (40333645)
NOMURA Miyuki 宮城県立がんセンター研究所, 薬物療法学部, 技師 (40390893)
SASAKI Nozomi 宮城県立がんセンター研究所, 薬物療法学部, 臨時職員 (50467429)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2007: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 呼吸器外科学 / プロテインホスファターゼ / スプライシング / 細胞内トランスポート / KIF3モーター / MAPK経路 / 遺伝子発現異常 / 遺伝子変異 / 肺癌 / 前癌病変 / 早期肺癌 / HRM / 組織バンク |
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| Research Abstract |
(1) Regulation of mRNA splicing, intracellular transport using KID3 motor, and ERK activation by protein phosphatases has been revealed.
(2) Expression of protein phosphatase genes in lung tumor tissues has been analyzed.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm.2010
Author(s)
Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H.
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Journal Title
Biochem Biophys Res Commun 393
Pages: 201-206
Related Report
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[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediaded cell-cel adhesion.2009
Author(s)
Tanuma N, Nomura M, Ikdea M, Kusugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
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Journal Title
Oncogene 28
Pages: 752-76
Related Report
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[Journal Article] siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma Pathobiology2008
Author(s)
Yamanaka S, Gu Z, Sato M, Fujisaki R, Inomata K, Sakurada A, Inoue A, Nukiwa T, Kondo T, Horii A
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Journal Title
Related Report
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[Journal Article] The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma, Biochem Biophys Res Commun2008
Author(s)
Gu Z, Mitsui H, Inomata K, Honda M, Endo C, Sakurada A, Sato M, Okada Y, Kondo T, Horii A
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Journal Title
Related Report
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[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1(PP1) to dephosphorylate the U2 small nuclesr ribonucleoprotein particle(snRNP)component2008
Author(s)
Tanuma N, Kim SE, Buellens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H
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Journal Title
spliceosome-associated protein 155 (Sap155). J Biol Chem 52
Pages: 35805-35814
Related Report
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[Journal Article] siRNA targeting against EGFR2008
Author(s)
Yamanaka S, Gu Z, Sato M, Fujisaki R, Inomata K, Sakurada A, Inoue A, Nukiwa T, Kondo T, Horii A
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Journal Title
a promising candidate for a novel therapeutic application to lung adenocarcinoma. Pathobiology 75(1)
Pages: 2-8
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