Molecular Analysis of Initiation and Termination in Bone Formation
| Project/Area Number |
19390399
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
MATSUO Koichi Keio University, 医学部, 准教授 (40229422)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Toru 慶應義塾大学, 医学部, 助教 (50338092)
TAKADA Yasunari 慶應義塾大学, 医学部, 助教 (40407086)
TOYAMA Yoshiaki 慶應義塾大学, 医学部, 教授 (40129549)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 骨・軟骨代謝 / 骨リモデリング / 骨硬化症 / Fral / トランスジェニックマウス / 骨芽細胞 / 破骨細胞 / カップリング / 耳小骨 |
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| Research Abstract |
本研究では、発生過程と骨折治癒過程における内軟骨性骨化の起動メカニズムを解明した。発生過程の軟骨形成は正常で、骨折時の炎症性メディエーターの産生が低下しているトランスジェニックマウスを解析したところ、骨折線の融合不全を起こしていた。徐放性のPGE2ペレットを骨折線近傍に投与したところ、軟骨形成が回復し、骨折融合が促進された。すなわち、骨形成プログラムの起動メカニズムが発生過程と修復過程とで異なることが明らかになった。
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.2009
Author(s)
Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y. Suda, T., Matsuo, K.
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Journal Title
Journal of Biological Chemistry (未定)(印刷中)
Related Report
Peer Reviewed
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[Journal Article] RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator2008
Author(s)
Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y.
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Journal Title
Immunity 29
Pages: 438-450
Related Report
Peer Reviewed
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[Presentation] EphB/ephrin-B interactions assist in MSC niche maintenance and contribute to bone remodelling following injury2009
Author(s)
Arthur, A., Stylianou, C., Koblar, S. A., Matsuo, K., Gronthos, S.
Organizer
2nd Joint Meeting of the International Bone & Mineral Society and the Australian and New Zealand Bone & Mineral Society
Place of Presentation
Sydney, Austria
Related Report
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[Presentation] Late expression of c-Fos during osteoclast differentiation determines osteoclast survival and bone mass2009
Author(s)
Takada, Y., Irie, N., Grech, L., Nakamura, T., Kato, S., Wagner, E. F., Matsuo, K.
Organizer
2nd Joint Meeting of the International Bone & Mineral Society and the Australian and New Zealand Bone & Mineral Society
Place of Presentation
Sydney, Austria
Related Report
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[Presentation] The POZ-Zn Transcriptional Regulator OCZF/LRF Is Induced by RANKL and Increases c-Fos Expression in Osteoclastogenesis2007
Author(s)
Kukita, A., Shobuike, T., Asagiri, M., Takayanagi, H., Pessler, F., Matsuo, K., Kukita, T.
Organizer
29th Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Hawaii, USA
Related Report
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[Presentation] The POZ-Zn Transcriptional Regulator OCZF/LRF Is Induced by RANKL and Increases c-Fos Expression in Osteoclastogenesis.2007
Author(s)
Kukita, A., Shobuike, T., Asagiri, M., Takayanagi, H., Pessler, F., Matsuo, K., Kukita, T.
Organizer
29^<th> Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Hawaii,USA
Related Report
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