• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Technology of multi-layered tissue engineering for the head and neck organs

Research Project

Project/Area Number 19390437
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionFukushima Medical University

Principal Investigator

OMORI Koichi  Fukushima Medical University, 医学部, 教授 (10233272)

Co-Investigator(Kenkyū-buntansha) HAZAMA Akihiro  福島県立医科大学, 医学部, 教授 (60218394)
NAKAMURA Tatsuo  京都大学, 再生医学研究所, 准教授 (70227908)
WADA Ikuo  福島県立医科大学, 医学部, 教授 (40182969)
Co-Investigator(Renkei-kenkyūsha) HAZAMA Akihiro  福島県立医科大学, 医学部, 教授 (60218394)
NAKAMURA Tatsuo  京都大学, 再生医学研究所, 准教授 (70227908)
WADA Ikuo  福島県立医科大学, 医学部, 教授 (40182969)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2007: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywords移植・再生医療 / 細胞・組織 / バイオテクノロジー / 線維芽細胞 / 頭頸部
Research Abstract

本研究の目的は頭頸部臓器切除後の機能障害の回避とQuality of Lifeの向上をはかり、国民の健康に貢献することにある。頭頸部組織再生をはかるために、線維芽細胞を用いて早期に気管上皮を再生させることができた。歯肉由来線維芽細胞は上皮形成効果が高いこと、脂肪組織由来幹細胞は血管新生能があることを明らかにした。複数の細胞を導入して人工材料を作製し、これを移植し頭頸部の多層構造を同時に再生させる基盤技術を開発した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (55 results)

All 2009 2008 2007 Other

All Journal Article (21 results) (of which Peer Reviewed: 15 results) Presentation (32 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 耳鼻咽喉科臨床の進歩-喉頭・気管の再生医療-2009

    • Author(s)
      大森孝一, 中村達雄, 多田靖宏, 野本幸男, 鈴木輝久, 金丸眞一, 安里亮, 山下勝, 岡野渉
    • Journal Title

      日本耳鼻咽喉科学会会報 112(3)

      Pages: 104-109

    • NAID

      10026279212

    • Related Report
      2008 Final Research Report
  • [Journal Article] 移植細胞の動態観察のためのin vivo蛍光・発光標識法2009

    • Author(s)
      東恒仁, 野本幸男, 小林謙, 大森孝一, 和田郁夫
    • Journal Title

      Surger Frontier 16(1)

      Pages: 79-84

    • Related Report
      2008 Final Research Report
  • [Journal Article] 耳鼻咽喉科臨床の進歩-喉頭・気管の再生医療-.2009

    • Author(s)
      大森孝一, 他
    • Journal Title

      日本耳鼻咽喉科学会会報 112

      Pages: 104-109

    • NAID

      10026279212

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea2008

    • Author(s)
      Omori K, Tada Y, Suzuki T, Nomoto Y, Matsuzuka T, Kobayashi K, Nakamura T, Kanemaru S, Yamashita M, Asato R
    • Journal Title

      Ann Otol Rhinol Laryngol 117(9)

      Pages: 673-678

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ tissue engineering of the cricoid and trachea in a canine model2008

    • Author(s)
      Omori K, Nakamura T, Kanemaru S, Magrufov A, Yamashita M, Shimizu Y
    • Journal Title

      Ann Otol Rhinol Laryngol 117(8)

      Pages: 609-613

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue-engineered airway replacement2008

    • Author(s)
      Sato T, Nakamura T
    • Journal Title

      Lancet 372(9655)

      Pages: 2023-2030

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of tracheal epithelium utilizing a novel bi-potential collagen scaffold2008

    • Author(s)
      Tada Y, Takezawa Y, Suzuki T, Nomoto Y, Kobayashi K, Nakamura T, Omori K
    • Journal Title

      Ann Otol Rhinol Laryngol 117(5)

      Pages: 359-365

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replacement of the left main bronchus with a tissue-engineered prosthesis in a canine model2008

    • Author(s)
      Sato T, Tao H, Araki M, Ueda H, Omori K, Nakamura T
    • Journal Title

      Ann Thoracic Surgery 86(2)

      Pages: 422-428

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of the trachea using a bio-engineered scaffold with adipose-derived stem cells2008

    • Author(s)
      Suzuki T, Kobayashi K, Tada Y, Suzuki Y, Wada I, Nakamura T, Omori K
    • Journal Title

      Ann Otol Rhinol Laryngol 117(6)

      Pages: 453-463

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of fibroblasts on epithelial regeneration on the surface of a bioengineered trachea2008

    • Author(s)
      Nomoto Y, Kobayashi K, Tada Y, Wada I, Nakamura T, Omori K
    • Journal Title

      Ann Otol Rhinol Laryngol 117(1)

      Pages: 59-64

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 気道再建と再生医療2008

    • Author(s)
      大森孝一, 中村達雄, 多田靖宏, 野本幸男, 鈴木輝久, 小林謙, 金丸眞一, 安里亮, 山下勝
    • Journal Title

      耳鼻と臨床 54(5)

      Pages: 271-279

    • NAID

      130004405156

    • Related Report
      2008 Final Research Report
  • [Journal Article] 細胞移植による声帯再生のための細胞培養液の検討2008

    • Author(s)
      金丸眞一, 梅田裕生, 末廣篤, 大野恒久, 木谷芳晴, 岸本曜, 田村芳寛, 平野滋, 大森孝一
    • Journal Title

      喉頭 20(1)

      Pages: 1-4

    • NAID

      10024456971

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effect of fibroblasts on epithelial regeneration on the surface of a bioengineered trachea.2008

    • Author(s)
      Nomoto Y, Omori K, et al.
    • Journal Title

      Ann Otol Rhinol Laryngol 117

      Pages: 59-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of tracheal epithelium utilizing a novel bi-potential collagen scaffold.2008

    • Author(s)
      Tada Y, Omori K, et al.
    • Journal Title

      Ann Otol Rhinol Laryngol 117

      Pages: 359-65

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ tissue engineering of the cricoid and trachea in a canine model.2008

    • Author(s)
      Omori K, et al.
    • Journal Title

      Ann Otol Rhinol Laryngol 117

      Pages: 609-613

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replacement of the left main bronchus with a tissue-engineered prosthesis in a canine model.2008

    • Author(s)
      Sato T, Omori K, et al.
    • Journal Title

      Ann Thoracic Surgery 86

      Pages: 422-428

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea.2008

    • Author(s)
      Omori K, et al.
    • Journal Title

      Ann Otol Rhinol Laryngol 117

      Pages: 673-678

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気道再建と再生医療.2008

    • Author(s)
      大森孝一, 他
    • Journal Title

      耳鼻と臨床 54

      Pages: 271-279

    • NAID

      130004405156

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Potential of heterotopic fibroblasts as autologous transplanted cells for tracheal epithelial regeneration2007

    • Author(s)
      Kobayashi K, Suzuki T, Nomoto Y, TadaY, Miyae M, Hazama A, Nakamura T, Omori K
    • Journal Title

      Tissue Engineering 13(9)

      Pages: 2175-2184

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration of canine skull using bone marrow - derived stromal cells and β-tricalcium phosphate2007

    • Author(s)
      Umeda H, Kanemaru S, Yamashita M, Kishimoto M, Tamura Y, Nakamura T, Omori K, Hirano S, Ito J
    • Journal Title

      Laryngoscope 117(6)

      Pages: 997-1003

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potentlal of heterotopic fibroblasts as autologous transplanted cells for tracheal epithelial regeneration2007

    • Author(s)
      Kobayashi
    • Journal Title

      Tissue Engineering 13(9):

      Pages: 2175-2184

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 線維芽細胞を用いたTissue Engineering によるウサギ気管再生.2009

    • Author(s)
      岡野 渉, 大森孝一, 他
    • Organizer
      第21回日本喉頭科学会
    • Place of Presentation
      前橋市
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tissue Engineeringによるウサギ気管再生 : 線維芽細胞の有用性2009

    • Author(s)
      岡野渉, 野本幸男, 多田靖宏, 大森孝一
    • Organizer
      第8回日本再生医療医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Tissue Engineering によるウサギ気管再生 : 線維芽細胞の有用性.2009

    • Author(s)
      岡野 渉, 大森孝一, 他
    • Organizer
      第8回日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 〔指定演題〕組織工学的手法による気道狭窄に対する治療2008

    • Author(s)
      金丸眞一, 平野滋, 田村芳寛, 末廣篤, 梅田裕生, 大森孝一, 伊藤壽一
    • Organizer
      第60回日本気管食道科学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] ウサギ線維芽細胞を含有した人工材料による気管の再生2008

    • Author(s)
      岡野渉, 野本幸男, 鈴木輝久, 多田靖宏, 中村達雄, 大森孝一
    • Organizer
      第60回日本気管食道科学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 〔指定演題3 : 気管狭窄の治療〕指18. 組織工学的手法による気道狭窄に対する治療.2008

    • Author(s)
      金丸眞一, 大森孝一, 他
    • Organizer
      第60回日本気管食道科学会
    • Place of Presentation
      熊本市
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 〔Instruction Course〕Instructor, Tissue engineering for regenerative medicine2008

    • Author(s)
      Omori K
    • Organizer
      The 2008 Annual Meeting of American Academy of Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Chicago, USA,
    • Year and Date
      2008-09-22
    • Related Report
      2008 Final Research Report
  • [Presentation] [Instruction Courses] Tissue engineering for regenerative medicine.2008

    • Author(s)
      Omori K
    • Organizer
      2008 AAO-HNSF Annual Meeting & OTO EXPO
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2008-09-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウサギ線維芽細胞を含有した人工材料による気管の再生2008

    • Author(s)
      岡野渉, 野本幸男, 鈴木輝久, 多田靖宏, 中村達雄, 大森孝一
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Final Research Report
  • [Presentation] ウサギ線維芽細胞を含有した人工材料による気管の再生.2008

    • Author(s)
      岡野 渉, 大森孝一, 他
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 〔シンポジウム〕気道領域の再生医療2008

    • Author(s)
      大森孝一
    • Organizer
      第33回日本外科系連合学会学術集会
    • Place of Presentation
      浦安市
    • Year and Date
      2008-06-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 〔シンポジウム5 : 再生医療の外科手術への応用〕気道領域の再生医療.2008

    • Author(s)
      大森孝一, 他
    • Organizer
      第33回日本外科系連合学会学術集会
    • Place of Presentation
      浦安市
    • Year and Date
      2008-06-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 〔シンポジウム〕喉頭・気管の再生医療2008

    • Author(s)
      大森孝一
    • Organizer
      第109回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 〔シンポジウム2 : 耳鼻咽喉科臨床の進歩〕喉頭・気管の再生医療.2008

    • Author(s)
      大森孝一
    • Organizer
      第109回日本耳鼻咽喉科学会総会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bio-engineered scaffold with fibroblasts for tracheal regeneration in rabbit model2008

    • Author(s)
      Okano W, Nomoto Y, Suzuki T,Nakamura T, Omori K
    • Organizer
      The 129th Annual Meeting of the American Laryngological Association Orlando
    • Place of Presentation
      USA
    • Year and Date
      2008-05-02
    • Related Report
      2008 Final Research Report
  • [Presentation] The investigation of the potentiality of the cell culture medium with autologous blood serum for cell transplantation therapy for injured vocal fold2008

    • Author(s)
      Kanemaru S, Nakamura T, Yamashita M, Umeda H, Oono T, Hirano S, Ito J, Omori K
    • Organizer
      The 88th Annual Meeting ofAmerican Broncho-EsophagologicalAssociation, Orlando
    • Place of Presentation
      USA
    • Year and Date
      2008-05-02
    • Related Report
      2008 Final Research Report
  • [Presentation] The investiagation of the potentiality of the cell culture medium with autologous blood serum for cell transplantation therapy for injured vocal fold.2008

    • Author(s)
      Kanemaru S, Omori K, et al.
    • Organizer
      88th American Broncho-Esophagological Association
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bio-engineered scaffold with fibroblasts for tracheal regeneration in rabbitmodel.2008

    • Author(s)
      Okano W, Omori K, et al.
    • Organizer
      129th American Laryngological Association
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 〔Mini-Symposium〕Regenerative medicine for airway organs2008

    • Author(s)
      Omori K, Tada Y, Nakaura T, Kanemaru S, Suzuki T, Nomoto Y, Okano W
    • Organizer
      The 15th World Congress for Bronchoesophagology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-04-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 〔Mini-Symposium〕Bioengineered trachea with fibroblasts2008

    • Author(s)
      Nomoto Y, Okano W, Kbayashi K, Tada Y, Wada I, Nakamura T, WatanOmori K
    • Organizer
      The 15th World Congress for Bronchoesophagology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-04-01
    • Related Report
      2008 Final Research Report
  • [Presentation] [Mini-Symposium]Regenerative medicine for airway organs.2008

    • Author(s)
      Omori K, et al.
    • Organizer
      15th World Congress for Bronchoesophagology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-04-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] [Mini-Symposium]Bioengineered trachea with fibroblasts.2008

    • Author(s)
      Nomoto Y, Omori K, et al.
    • Organizer
      15th World Congress for Bronchoesophagology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-04-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウサギ線維芽細胞含有モデルによる人工気管の作製2008

    • Author(s)
      岡野 渉
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 自己間葉系細胞移植による声帯の再生のための足場の検討2008

    • Author(s)
      金丸 眞一
    • Organizer
      第20回日本喉頭科学会総会学術講演会
    • Place of Presentation
      佐賀県佐賀市
    • Year and Date
      2008-03-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Evaluation of bi-potential scaffold for regeneration of the trachea - in vitro and in vivo studies2008

    • Author(s)
      Tada Y, Takezawa T, Suzuki T, Kobayashi K, Nakamura T, Omori K
    • Organizer
      The 111th Annual Meeting of the Triological Society Orlando
    • Place of Presentation
      USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Evaluation of bi-potential scaffold for regeneration of the trachea - in vitro and in vivo studies.2008

    • Author(s)
      Tada Y, Omori K, et al.
    • Organizer
      129th American Laryngological Association
    • Place of Presentation
      Orlando, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウサギ線維芽細胞を含有した人工材料による気管の再生.2008

    • Author(s)
      岡野 渉, 大森孝一, 他
    • Organizer
      第60回日本気管食道科学会
    • Place of Presentation
      熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨再生誘導法を取り入れた犬頭蓋骨再生2007

    • Author(s)
      梅田 裕生
    • Organizer
      第10回日本組織工学会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 線維芽細胞を付加した人工気管の作製2007

    • Author(s)
      岡野 渉
    • Organizer
      第59回日本気管食道科学会総会ならびに学術講演会
    • Place of Presentation
      群馬県前橋市
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 〔Instruction Courses〕Tissue engineering for regenerative medicine2007

    • Author(s)
      Omori K
    • Organizer
      The 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-09-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨再生誘導法を取り入れた組織工学的犬頭蓋骨再生2007

    • Author(s)
      梅田 裕生
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京都新宿区
    • Year and Date
      2007-08-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Behavior of the Autologous Bone Marrow Derived Stromal Cslls Implanted in the Vocal Fold on Healing Process2007

    • Author(s)
      Shin-ichi Kanemaru
    • Organizer
      The American Broncho-Esophagological Association
    • Place of Presentation
      San Diego, California
    • Year and Date
      2007-04-27
    • Related Report
      2007 Annual Research Report
  • [Book] 耳鼻咽喉科・頭頸部外科領域の再生医療.「今日の耳鼻咽喉科・頭頸部外科治療指針(第3版)」(森山寛, 他編)2008

    • Author(s)
      大森孝一
    • Publisher
      医学書院, 東京
    • Related Report
      2008 Final Research Report
  • [Remarks] 大森孝一 : 〔放送〕喉頭・気管領域の再生治療. ラジオNIKKEI「病学講座」2007年8月1日

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi