| Project/Area Number |
19390459
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
SHIOZAKI Tadahiko Osaka University, 医学系研究科, 助教 (60278687)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hisashi 大阪大学, 名誉教授 (90127241)
OGURA Hiroshi 大阪大学, 医学系研究科, 講師 (70301265)
TASAKI Osamu 大阪大学, 医学系研究科, 助教 (90346221)
MATSUMOTO Naoya 大阪大学, 医学部附属病院, 助教 (50359808)
田中 裕 順天堂大学, 医学部, 教授 (90252676)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Hiroshi 順天堂大学, 医学部, 教授 (90252676)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 心肺蘇生 / 脳内酸素飽和度 / 脳蘇生 / 蘇生後脳症 / 脳低温療法 / 蘇生後低酸素脳症 / 脳酸素飽和度 / 神経学的予後 / 近赤外線 / 蘇生後脳定 / 脳温度 / ウツタイン様式 / 初期心電図 |
|---|
| Research Abstract |
In clinical study, we monitored bilateral regional cerebral oxygen saturation using near infrared spectroscopy (the TOS-96) during cardiopulmonary resuscitation continuously just after they arrived at hospital. Our studies suggest that extracorporeal cardiopulmonary resuscitation may improve regional cerebral oxygen saturation in patients with out-of-hospital cardiac arrest and their neurological outcome. In animal studies, using a gerbil model of global ischemia-reperfusion, we assessed the effects of hypothermia on physiological parameters and evaluated the optimal timing for induction of hypothermia to achieve a better survival rate. Under normothermic cerebral ischemia, the survival rate was dramatically decreased by induction of 15 to 20 minutes of ischemia. Induction of hypothermia significantly improved the survival rate only when induction of hypothermia occurred less than 10 minutes after ischemic onset.
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