| Project/Area Number |
19390473
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIMURA Riko Osaka University, 大学院・歯学研究科, 准教授 (60294112)
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| Co-Investigator(Kenkyū-buntansha) |
YONEDA Toshiyuki 大阪大学, 大学院・歯学研究科, 教授 (80142313)
HATA Kenji 大阪大学, 大学院・歯学研究科, 助教 (80444496)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 骨芽細胞 / 未分化間葉系細胞 / 骨形成 / インディアンヘッジホッグ / 細胞内シグナリング / 転写因子 / PTHrP / Ihh / Gli / Runx2 |
|---|
| Research Abstract |
Indian hedgehog (Ihh) has been shown to play important roles in development of several tissues including skeletal tissues. In particular, Ihh conducts bone formation by regulating osteoblast and chondrocyte differentiation. In this study, to understand the mechanisms of Ihh, we investigated mechanisms and roles of Ihh signaling pathway. We found that Ihh controls expression and function of transcription factors, Gli family members, thereby regulating osteoblast differentiation. Furthermore, we demonstrated that Ihh signaling collaborates with Bone morphogenetic protein 2 (BMP2) signaling and Runx2, and that this cross-talk enhances osteoblast differentiation.
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