Induction of Bone Regeneration by Controlled Release of Osteogenesis/Angiogenesis Factors from Titanium Implants
| Project/Area Number |
19390494
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Osaka University |
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Principal Investigator |
YATANI Hirofumi Osaka University, 大学院・歯学研究科, 教授 (80174530)
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| Co-Investigator(Kenkyū-buntansha) |
EGUSA Hiroshi 大阪大学, 大学院・歯学研究科, 助教 (30379078)
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
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| Co-Investigator(Renkei-kenkyūsha) |
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Keywords | インプラント / 骨再生 / 薬剤徐放 / 小分子化合物 / ペプチド / 骨芽細胞 / 破骨細胞 / b-FGF |
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| Research Abstract |
The aim of this study is to establish a novel technology to achieve efficient bone regeneration by controlled release of bioactive factors from titanium implants. We designed a titanium implant chamber which contains a biodegradable material releasing bioactive factor (b-FGF). We found that this system induces bone regeneration around the implant in an animal model. We also identified osteogenesis inducible peptide and small molecule, and elucidated mechanisms of these molecules on bone regeneration.
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Report
(5 results)
Research Products
(52 results)
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[Journal Article] Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.2007
Author(s)
Hamada Y, Egusa H, Kaneda Y, Hirata I, Kawaguchi N, Hirao T, Matsumoto T, Yao M, Daito K, Suzuki M, Yatani H, Daito M, Okazaki M, Matsuura N
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Journal Title
Dental Materials Journal 26
Pages: 487-492
NAID
Related Report
Peer Reviewed
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[Journal Article] Synthetic osteopontin-derived peptide svvyglr can induce neovascularization in artificial bone marrow scaffold biomaterials2007
Author(s)
Hamada Y, Egusa H, Kaneda Y, Hirata I, Kawaguchi N, Hirao T, Matsumoto T, Yao M, Daito K, Suzuki M, Yatani H, Daito M, Okazaki M, Matsuura N
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Journal Title
Dental Materials Journal 26(4)
Pages: 487-492
NAID
Related Report
Peer Reviewed
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[Journal Article] Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold2007
Author(s)
Hamada Y, Egusa H, Kaneda Y, Hirata I, Kawaguchi N, Hirao T, Matsumoto T, Yao M, Daito K, Suzuki M, Yatani H, Daito M, Okazaki M, Matsuura N
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Journal Title
Dental Materials Journal
Volume: 26
Pages: 487-492
Related Report
Peer Reviewed
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