Development of new therapy for periodontal disease based on regulating exocytosis
| Project/Area Number |
19390538
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | National Institute for Longevity Sciences,NCGG
国立長寿医療センター研究所 |
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Principal Investigator |
MATSUSHITA Kenji 国立長寿医療センター研究所, 口腔疾患研究部, 部長 (90253898)
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| Co-Investigator(Kenkyū-buntansha) |
INTO Takeshi 国立長寿医療センター研究所, 口腔疾患研究部, 室長 (10360918)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 免疫・感染・炎症 / サイトカイン / 高血圧 / 歯周病 / 開口放出 / 炎症性サイトカイン / 歯周免疾機能学 / 膜輸送 / 医薬分子設計 / 細胞情報伝達機構 |
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| Research Abstract |
We explored meaning of exocytosis on pathogenesis of periodontal disease and possibility of that regulation. We found that various stimulants from periodontopathic bacteria induced exocytosis in keratinocytes, immune cells, and endothelial cells in periodontal tissue and it was regulated nitric oxide.
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Report
(3 results)
Research Products
(55 results)
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[Presentation]2009
Author(s)
Amano K, Nakashima M, Zheng L, Iohara K, Matsui H, Yamasaki M, Matsushita K, Nakamura H
Organizer
Japanese Association for Dental Research
Place of Presentation
Nagoya
Year and Date
2009-11-30
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[Presentation] A Potential New Cell Source for Vasculogenesis in Ischemia, CD31-;CD146- Side Population Cells from Dental Pulp2007
Author(s)
Nakashima M, Iohara K, Zheng L, Wake H, Ito M, Wakita H, Nabekura J, Nakamura H, Into T, Matsushita K
Organizer
The American Society for Cell Biology 47th Annual Meeting
Place of Presentation
Washington, DC, USA
Year and Date
2007-12-04
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