| Project/Area Number |
19500256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KARASHIMA Akihiro 東北大学, 大学院・情報科学研究科, 助教 (40374988)
NAKAO Mitsuyuki 東北大学, 大学院・情報科学研究科, 教授 (20172265)
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| Project Period (FY) |
2007 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳情報処理 / 皮質神経回路モデル / ニューロン / スパイクタイミング依存性シナプス可塑性 / 介在ニューロン / 同期 / 自己組織化 / 時空間ダイナミクス / トポロジー / 多細胞記録 / スモールワールド / 神経回路網 / シナプス可塑性 / 独立成分分析 / トポロジ / 海馬 / 大脳皮質 / リアルタイム信号処理 / 機能的結合 / 自己組織 / 機能手結合 |
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| Research Abstract |
In this study, we investigated the dynamics and self-organization of cortical local neural network by electrophysiological experiments on acute brain slices, mathematical modeling and computer simulations of realistic neural network. It was found that autonomous change of functional neural connections occurred associated with metastable dynamics of ensemble neuronal activities in the local neural circuit. In addition, it is suggested that a certain degree of robustness of the distribution of efficacy of functional neuronal connections against the self-organization of the network.
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