Elucidation of the physiological function of ALS2 and mechanism for motor neuron degeneration through the identification of ALS2 activators
| Project/Area Number |
19500330
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokai University |
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Principal Investigator |
HADANO Shinji (2008-2009) Tokai University, 医学部, 准教授 (60281375)
國田 竜太 (2007) Tokai University, 医学部, 奨励研究員 (90449124)
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| Co-Investigator(Kenkyū-buntansha) |
秦野 伸二 東海大学, 医学部, 准教授 (60281375)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子 / 細胞 / 神経生物学 / 脳神経疾患 / シグナル伝逹 / 生体膜輸送 / 蛋白質 / 神経科学 / シグナル伝達 / 運動ニューロン疾患 / ALS2 / マクロピノサイトーシス / Rab5 / Rac1 / 筋委縮性側索硬化症 / エフェクター |
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| Research Abstract |
Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of progressive neurodegenerative disorders characterized by a selective loss of motor neurons in the cerebral cortex, brainstem, and spinal cord. Currently, the mechanism for the selective degeneration of motor neurons is unclear. We focus on the newly-identified ALS causative gene product, called ALS2, and investigate the molecular function of ALS2 and its activators. We here identified Rac1 as a novel ALS2 activator, and revealed that ALS2 plays a role in macropinocytosis and endosome fusion in cells. Our study will contribute to,define the molecular mechanisms underlying the neuronal dysfunction and degeneration in ALS.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] A dopamine receptor antagonist L-745, 870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice2008
Author(s)
Tanaka K, Okada Y, Kanno T, Otomo A, Yanagisawa Y, Shouguchi-Miyata J, Suga E, Kohiki E, Onoe K, Osuga H, Aoki M, Hadano S, Itoyama Y, Ikeda JE
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Journal Title
Exp Neurol 211
Pages: 378-386
Related Report
Peer Reviewed
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[Presentation] ALS2/alsin, a Rab5 guanine nucleotide exchange factor, acts as a regulator for autophagosomalendolysosomal protein degradation. Keystone Symposia, Cell Death Pathway2010
Author(s)
Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Akatsuka A, Koike M, Aoki M, Uchiyama Y, Itoyama Y, Ikeda JE
Organizer
Apoptosis, Autophagy and Necrosis (X3)
Place of Presentation
Vancouver, Canada
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