Study of a novel K^+ channel in generation of neuropathic pain
| Project/Area Number |
19500353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
YAMAMOTO Satoshi Hyogo University of Health Sciences, 薬学部, 教授 (60220464)
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| Co-Investigator(Kenkyū-buntansha) |
西崎 知之 兵庫医科大学, 医学部, 教授 (00221474)
永田 徹 兵庫医科大学, 医学部, 准教授 (60131588)
藤川 浩一 兵庫医科大学, 医学部, 講師 (40312136)
山本 英幸 兵庫医科大学, 医学部, 助教 (70373529)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIZAKI Tomoyuki 兵庫医科大学, 医学部, 教授 (00221474)
NAGATA Tetsu 兵庫医科大学, 医学部, 准教授 (60131588)
YAMAMOTO Hideyuki 兵庫医科大学, 医学部, 講師 (70373529)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 感覚系神経生理学 / 神経因性疼痛 / イオンチャネル / 熱 / 脊髄後根神経節 / 脊髄後根神経 / アドレナリン受容体 / Kチャネル |
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| Research Abstract |
The results of the present study show that heat-activated K^+ channel currents in DRG neurons are inhibited by both PKC and PKA as mediated via alpha1 and beta adrenergic receptors, respectively. This may represent a new insight into regulation of thermosensation via a noradrenergic pathway, leading to revealing the mechanisms of neurogenic pain.
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Report
(3 results)
Research Products
(6 results)
