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Reorganization of brain motor network after stroke visualized with fMRI and tractography

Research Project

Project/Area Number 19500458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionInternational University of Health and Welfare

Principal Investigator

KATO Hiroyuki  International University of Health and Welfare, 大学病院, 教授 (60224531)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Ritsuo  国際医療福祉大学, 大学病院, 教授 (50254917)
HIWATARI Masao  国際医療福祉大学, 大学院, 教授 (20189898)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords脳神経疾患 / リハビリテーション / 脳卒中 / 脳機能画像診断 / 片麻痺 / fMRI
Research Abstract

We performed both fMRI and diffusion tensor tractography in stroke patients in an attempt to elucidate the mechanism of motor recovery after stroke. The observed change in the brain motor network after stroke was a dynamic process including (1) functional recovery from reversible damage and (2) compensation, recruitment, and reorganization of brain motor network, depending on the damage to the pyramidal tract. This change was observed within the first 2 months after stroke, suggesting the existence of a critical period.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (44 results)

All 2009 2008 2007

All Journal Article (19 results) (of which Peer Reviewed: 10 results) Presentation (23 results) Book (2 results)

  • [Journal Article] Reaction time differences between left-and right handers during mental rotation of hand pictures2009

    • Author(s)
      Takeda K, Shimoda N, Sato Y, Ogano M, Kato H
    • Journal Title

      Laterality (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 画像で見る脳の再構築2009

    • Author(s)
      加藤宏之、武田湖太郎
    • Journal Title

      37(8)

      Pages: 699-704

    • Related Report
      2009 Final Research Report
  • [Journal Article] NIRSを用いた脳機能評価2009

    • Author(s)
      武田湖太郎、加藤宏之
    • Journal Title

      Clinical Neuroscience 27

      Pages: 1055-1057

    • Related Report
      2009 Final Research Report
  • [Journal Article] 随意運動の機能回復:機能的MRIの知見2009

    • Author(s)
      加藤宏之
    • Journal Title

      Jpn J Rehabil Med 46(1)

      Pages: 17-21

    • NAID

      10030857133

    • Related Report
      2009 Final Research Report
  • [Journal Article] 画像で見る脳の再構築2009

    • Author(s)
      加藤宏之, 武田湖太郎
    • Journal Title

      総合リハ 37

      Pages: 699-704

    • Related Report
      2009 Annual Research Report
  • [Journal Article] NIRSを用いた脳機能評価2009

    • Author(s)
      武田湖太郎, 加藤宏之
    • Journal Title

      Clinical Neuroscience 27

      Pages: 1055-1057

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 随意運動の機能回復 : 機能的MRIの知見2009

    • Author(s)
      加藤宏之
    • Journal Title

      Jpn J Rehabil Med 46

      Pages: 17-21

    • NAID

      10030857133

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 近赤外光トポグラフィーによる運動機能の評価2009

    • Author(s)
      武田湖太郎, 加藤宏之, 渡辺英寿
    • Journal Title

      臨床脳波 50

      Pages: 397-404

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Sensorimotor cortex activation during mirror therapy in healthy right-handed subjects: a study with near-infrared spectroscopy2008

    • Author(s)
      Imai I, Takeda K, Shiomi T, Tanuguchi T, Kato H
    • Journal Title

      J Phys Ther Sci 20

      Pages: 141-145

    • NAID

      10024159266

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral laterality differences in handedness: a mental rotation study with NIRS2008

    • Author(s)
      Shimoda N, Takeda K, Imai I, Kaneko J, Kato H
    • Journal Title

      Neurosci Lett 430(1)

      Pages: 43-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外光トポグラフィーによる運動機能の評価2008

    • Author(s)
      武田湖太郎、加藤宏之、渡辺英寿
    • Journal Title

      臨床脳波 50

      Pages: 397-404

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sensorimotor cortex activation during mirror therapy in healthyright-handed subjects : a study with near-infrared spectroscopy2008

    • Author(s)
      Imai I, Takeda K, Shiomi T, Tanuguchi T, Kato H
    • Journal Title

      J Phys Ther Sci 20

      Pages: 141-145

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Near-infrared spectroscopy データ解析ソフトウェアの開発2008

    • Author(s)
      武田湖太郎, 加藤宏之
    • Journal Title

      脳科学とリハ 8

      Pages: 15-20

    • NAID

      130007511377

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頭部傾斜がNear-infrared spectroscopy計測に与える影響2008

    • Author(s)
      武田湖太郎, 渡邉観世子, 郡司幸也, 加藤宏之
    • Journal Title

      脳科学とリハ 8

      Pages: 21-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral laterality differences in handedness:amental rotation study with NIRS2008

    • Author(s)
      Shimoda N
    • Journal Title

      Neurosci Lett 430

      Pages: 43-47

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shift of motor activation areas during recovery from hemiparesis after cerebral infarction: a longitudinal study with near-infrared spectroscopy2007

    • Author(s)
      Takeda K, Gomi Y, Imai I, Shimoda N, Hiwatari M, Kato H
    • Journal Title

      Neurosci Res 59(2)

      Pages: 136-44

    • NAID

      10024417178

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳機能再構築に関する脳機能画像診断の実際2007

    • Author(s)
      加藤宏之
    • Journal Title

      理学療法科学 22

      Pages: 7-12

    • NAID

      10018875217

    • Related Report
      2009 Final Research Report
  • [Journal Article] 慢性期脳卒中患者の麻痺手運動時における同側大脳半球の活性化-近赤外分光法による検討-2007

    • Author(s)
      武田湖太郎、五味幸寛、今井樹、下田信明、加藤宏之
    • Journal Title

      脳科学とリハ 7

      Pages: 15-20

    • NAID

      130007511383

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] shift of motor activation areas during recovery from hemiparesis after cerebral infarction:a longitudinal study with near-infrared spectroscopy2007

    • Author(s)
      Takeda K
    • Journal Title

      Neurosci Res 59

      Pages: 136-144

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 健常者および脳卒中片麻痺患者における手の心的回転課題遂行時の脳活動―近赤外分光法による検討―2009

    • Author(s)
      下田信明, 武田湖太郎, 加藤宏之
    • Organizer
      第16回医用近赤外線分光法研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] False positive/negative hemoglobin signal of near-infrared specteoscopy2009

    • Author(s)
      Takeda K, Osu R, Otaka Y, Kato H
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Motor imagery in mental rotation of hands in left- and right-handers: A behavioral and near-infrared spectroscopy study2009

    • Author(s)
      Shimoda N, Takeda K, Kato H
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Motor imagery in mental rotation of hands in left- and right-handers : A behavioral and near-infrared spectroscopy study2009

    • Author(s)
      下田信明, 武田湖太郎, 加藤宏之
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 手の心的回転―提示角度と反応時間の検討―2009

    • Author(s)
      武田湖太郎, 下田信明, 佐藤裕, 加藤宏之
    • Organizer
      第14回認知神経科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 手の心的回転―近赤外分光法による脳活動の検討―2009

    • Author(s)
      下田信明, 武田湖太郎, 加藤宏之
    • Organizer
      第14回認知神経科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] NIRSを用いた脳卒中後の片麻痺の回復と脳機能再構築の検討.2009

    • Author(s)
      加藤宏之、武田湖太郎、橋本律夫、下田信明、今井樹
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Related Report
      2009 Final Research Report
  • [Presentation] NIRSを用いた脳卒中後の片麻痺の回復と脳機能再構築の検討2009

    • Author(s)
      加藤宏之, 武田湖太郎, 橋本律夫, 下田信明, 今井樹
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Longitudinal NIRS study on motor-functional recovery after hemiparetic stroke2008

    • Author(s)
      Takeda K, Imai I, Shimoda N, Kato H
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Longitudinal NIRS study on motor-functional recovery after hemipareticstroke2008

    • Author(s)
      Takeda K, Imai I, Shimoda N, Kato H
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム:ニューロリハビリテーションへの臨床神経生理学の応用-脳卒中などへの応用を中心に-、「脳機能再構築に関する脳機能画像診断」2008

    • Author(s)
      加藤宏之
    • Organizer
      第38回日本臨床神経生理学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳機能再構築に関する脳機能画像診断2008

    • Author(s)
      加藤宏之
    • Organizer
      第38回日本臨床神経生理学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 頭部傾斜がNIRSデータへ与える影響:擬陽性の評価2008

    • Author(s)
      武田湖太郎、郡司幸也、渡邉観世子、加藤宏之
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 頭部傾斜がNIRSデータへ与える影響 : 擬陽性の評価2008

    • Author(s)
      武田湖太郎, 郡司幸也, 渡邉観世子, 加藤宏之
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム.脳の機能再編成:機能画像の知見から.「随意運動の機能回復;機能的MRIの知見」2008

    • Author(s)
      加藤宏之
    • Organizer
      第45回日本リハビリテーション医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-04
    • Related Report
      2009 Final Research Report
  • [Presentation] 随意運動の機能回復 : 機能的MRIの知見2008

    • Author(s)
      加藤宏之
    • Organizer
      第45回日本リハビリテーション医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Comparative study of motor related activation areas after hemiparetic stroke between well- and poorly recovered patients using near-infrared spectroscopy2007

    • Author(s)
      Takeda K, Gomi Y, Imai I, Shimoda N, Hiwatari M, Kato H
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Local cerebral hemodynamic response in frontal and parietal cortices during mental rotation of hand: a near-infrared spectroscopy study2007

    • Author(s)
      Shimoda N, Takeda K, Imai I, Kaneko J, Taniguchi T, Kato H
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Transient hyperactivation in bilateral motor related areas during recovery from poststroke mild hemiparesis - a study with NIRS -2007

    • Author(s)
      Takeda T, Imai I, Maruyama K, Gomi Y, Shimoda N, Hiwatari M, Kato H
    • Organizer
      23rd International Symposium on Cerebral Blood Flow, Metabolism & Function
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Transient hyperactivation in bilateral motor related areas during recovery from poststroke mild hemiparesis-a study with NIRS-2007

    • Author(s)
      Takeda K
    • Organizer
      23rd International Symposium on Cerebral BloodFlow Me tabolism & Function
    • Place of Presentation
      0saka,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Measurement of cerebral activation during different motor tasks of a lower limbusing near infrared spectroscopy2007

    • Author(s)
      Kaneko J
    • Organizer
      23rd lntemational Symposium on Cerebral Blood Flow Metabolism&Function
    • Place of Presentation
      0saka,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Comparative study of motor related activation areas after hemiparetic stroke between well-and poorly recovered patients using near-infrared spectroscopy2007

    • Author(s)
      Takeda K
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego,USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Local cerebral hemodynamic response in frontal and parietal cortices during mental rotation of hand:anear-infrared spectroscopy study2007

    • Author(s)
      Shimoda N
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego,USA
    • Related Report
      2007 Annual Research Report
  • [Book] 脳卒中に対する標準的理学療法介入(潮見泰蔵、編, 脳卒中になったら、まず何が行われるの?. 脳卒中の標準治療)2007

    • Author(s)
      加藤宏之
    • Publisher
      文光堂
    • Related Report
      2009 Final Research Report
  • [Book] 脳卒中に対する標準的理学療法介入2007

    • Author(s)
      加藤 宏之(分担執筆)
    • Publisher
      文光堂
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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