Molecular meohanisms of mechanosensing inskeletal muscles : Based on regulation system of atrogen expression
| Project/Area Number |
19500564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NIKAWA Takeshi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (20263824)
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| Co-Investigator(Kenkyū-buntansha) |
YASUI Matsuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00157984)
NAKAYA Yutaka 徳島大学, 大学院・ヘルスバシオサイエンス研究部, 教授 (50136222)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ユビキチンリガーゼ / 機械的ストレスの感知 / IGF-1シグナル / 運動器(筋・骨) / 蛋白質分解酵素 |
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| Research Abstract |
Cb1-bの発現が運動器の活動状態(機械的ストレス)と相関する非常に良い指標になることがわかった。この新しい知見は、Cb1-bの発現調節機序を解明できれば機械的ストレスに対する運動器の感知機構が明らかになることを強く示唆した。そこで、本研究で、Cb1-b遺伝子のプロモーター解析を行った結果、Egr-1とSp1の転写因子がCb1-bの発現をそれぞれ正と負に制御していることがわかった。さらに、これら転写因子の上流を解析すると、MAPK経路とくにERK-1/2経路がEgrの活性を誘導していた。ERK-1/2を活性化するものこそが、運動器の活動状態(機械的ストレス)の感知機構の重要なセンサーであることがほぼ明らかにした。申請者らは、それが膜上の蛋白質分解酵素ではないかという新たなメカニズムを提唱している。
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Report
(3 results)
Research Products
(51 results)
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[Journal Article] Awa(Tokushima)lactate-fermented tea as well as green tea enhance the effect of diet restriction on obesity in rats2009
Author(s)
Sogawa M, Seura T, Kohno S, Hirasaka K, Yamaguchi Y, Takagi R, Harada A, Okumura Y, Yamamoto S, Kishi K, Nikawa T
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Journal Title
J Med Invest 56(1-2)
Pages: 42-48
NAID
Related Report
Peer Reviewed
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[Journal Article] Polyphenols prevent clinorotation-induced expression of atrogenes in mouse C2C12 skeletal myotubes2009
Author(s)
Hemdan DII, Hirasaka K, Nakao R, Kohno S, Kagawa S, Abe T, Harada-Sukeno A, Okumura Y, Nakaya Y, Terao J, Nikawa T
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Journal Title
J Med Invest 56(1-2)
Pages: 26-32
NAID
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[Journal Article] Subcutaneous injection, from birth, of epigallocatechin-3-gallate, a component of green tea, limits the onset of muscular dystrophy in mdx mice : a quantitative histological, immunohistochemical and electrophysiological study2008
Author(s)
Nakae Y, Hirasaka K, Goto J, Nikawa T, Shono M, Yoshida M, Stoward PJ
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Journal Title
Histochem Cell Biol 129(4)
Pages: 489-501
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[Journal Article] Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice2008
Author(s)
Oarada M, Tsuzuki T, Gonoi T, Igarashi H, Kamei K, Nikawa T, Hirasaka K, Ogawa T, Miyazawa T, Nakagawa K, Kurita N
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Journal Title
Nutrition 24(1)
Pages: 67-75
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Peer Reviewed
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[Journal Article] Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice2008
Author(s)
Oarada M, Tsuzuki T, Gonoi T, Igarashi H, Kamei K, Nikawa T, Hirasaka K, Ogawa T, Miyazawa T, Nakagawa K, Kurita N
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Journal Title
Nutrition 24 (1)
Pages: 67-75
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[Journal Article] Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts2007
Author(s)
Furochi H, Tamura S, Mameoka M, Yamada C, Ogawa T, Hirasaka K, Okumura Y, Imagawa T, Oguri S, Ishidoh K, Kishi K, Higashiyama S, Nikawa T
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Journal Title
FEBS Lett 581(30)
Pages: 5743-50
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[Journal Article] Deficiency of Cb1-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice2007
Author(s)
Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Hamada N, Hosaka T, Nakaya Y, Ishidoh K, Obata T, Ebina Y, Gu H, Takeda S, Kishi K, Nikawa T
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Journal Title
Diabetes 56(10)
Pages: 2511-22
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[Journal Article]2007
Author(s)
Nakano S, Mishiro T, Takahara S, Yokoi H, Hamada D, Yukata K, Takata Y, Goto T, Egawa H, Yasuoka S, Furouchi H, Hirasaka K, Nikawa T, Yasui N. Nakano S, Mishiro T, Takahara S, Yokoi H, Hamada D, Yukata K, Takata Y, Goto T, Egawa H, Yasuoka S, Furouchi H, Hirasaka K, Nikawa T, Yasui N
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Journal Title
Clin Rheumatol 26(8)
Pages: 1284-92
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Peer Reviewed
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[Journal Article] Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice2007
Author(s)
Oarada M, Gonoi T, Tsuzuki T, Igarashi M, Hirasaka K, Nikawa T, Onishi Y, Toyotome T, Kamei K, Miyazawa T, Nakagawa K, Kashima M, Kurita N
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Journal Title
iosci Biotechnol Biochem 71(1)
Pages: 174-82
NAID
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Peer Reviewed
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