Basic study that examining immune regulatory effect of soy isoflavones.

• Project/Area Number: 19500685
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: SAKAI Tohru The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (40274196)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: イソフラボン / 免疫 / 大腸炎 / 大豆 / エクオール / サイトカイン / ゲニステイン / ダイゼイン

Research Abstract

Soy foods have been consumed for centuries in Asian countries. Human clinical and epidemiological studies have revealed many potential benefits of intake of soy products. In this study, we therefore investigated the effects of equol on ovalbumin (OVA)-speficic T cell and B cell responses in BALB/c mice. Mice that had been treated with 20mg/kg equol showed a significantly higher level of OVA-specifc IgE than that in control mice. Furthermore, equol perpetrated DSS-induced colitis in BALB/c mice.

Research Products

• [Journal Article] The soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/cmice. (2010)
  • Author(s): Sakai T., Furoku S., Nakamoto M., Shuto E., Hosaka T., Nishioka Y., Sone S.
  • Journal Title: J. Nutr. Sci. Vitawinol. 56 Pages: 72-76
  • NAID: 10025973044
• [Journal Article] The soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice. (2010)
  • Author(s): Sakai T
  • Journal Title: Journal of Nutritional Science and Vitaminology 56 Pages: 72-76
  • NAID: 10025973044
  • Peer Reviewed
• [Journal Article] Dietary trans fatty acid suppress the development of spontaneous atopic-like dermatitis in NC/Nga mice. (2009)
  • Author(s): SakaiT., lrei A.V., Matoba T., Yamamoto S.
  • Journal Title: J. Nutr. Scl. Vitaminol. 55 Pages: 412-416
  • NAID: 10025972125
  • Peer Reviewed
• [Journal Article] Hyper-Ag-specific Ab production in NC/Nga mice is not associated with deletion polymorphism in the promotor region of the FcyRllB gene. (2009)
  • Author(s): SakaiT., Nakamoto M., Shuto E.
  • Journal Title: Am. J. lmmunol. 5 Pages: 61-64
  • Peer Reviewed
• [Journal Article] Dietary trans fatty acid suppress the development of spontaneous atopic-like dermatitis in NC/Nga mice. (2009)
  • Author(s): Sakai T
  • Journal Title: Journal of Nutritional Science and Vitaminology 55 Pages: 412-416
  • NAID: 10025972125
  • Peer Reviewed
• [Journal Article] Hyper-Ag-specific Ab production in NC/Nga mice is not associated with deletion polymorphism in the promotor region of the Fc_YRIIB gene. (2009)
  • Author(s): Sakai T
  • Journal Title: American Journal of Immunology 5 Pages: 61-64
  • Peer Reviewed
• [Journal Article] Soy isoflavones and immunity. (2008)
  • Author(s): Sakai T., Kogiso M
  • Journal Title: Journal of Medical Investigation 55 Pages: 167-173
  • NAID: 130004465138
  • Peer Reviewed
• [Journal Article] Maturational arrest of thymocyte development is caused by a deletionin the receptor-like protein tyrosine phosphatase kappa in LEC rats. (2007)
  • Author(s): Kose H, et. al.
  • Journal Title: Genomics 89 Pages: 673-677
  • Peer Reviewed
• [Journal Article] Effect of Vietnamese common diet on postprandial blood glucose levelin adult females. (2007)
  • Author(s): Lin PY, et. al.
  • Journal Title: J. Nutr. Sci. Vitaminol 53 Pages: 247-252
  • Peer Reviewed
• [Journal Article] The nucleoside and nucleotide mixturee(OG-VI) rescues intesina-like epithehal cells from the cytotoxicity of chemotherapeutic agents. (2007)
  • Author(s): Ono K., et. al.
  • Journal Title: J. Med. Invest. 54 Pages: 235-242
  • Peer Reviewed
• [Presentation] 大豆イソフラボンの免疫調節作用に関する研究 (2009)
  • Author(s): 酒井徹, 中本真理子, 首藤恵美
  • Organizer: 第56回日本栄養改善学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-03
• [Presentation] 大豆イソフラボンの抗原特異的免役誘導に対する影響の検討 (2009)
  • Author(s): 酒井徹
  • Organizer: 日本栄養食糧学会
  • Place of Presentation: 長崎市
  • Year and Date: 2009-05-23
• [Presentation] 大豆イソフラボン(エクオールおよびフォルモノネチン)の抗原特異的免役誘導に対する影響の検討 (2009)
  • Author(s): 酒井徹, 中本真理子, 首藤恵美
  • Organizer: 第63回日本栄養食糧学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2009-05-22
• [Presentation] 大豆イソフラボンであるエクオールは、免疫機能にどのような影響をおよぼすか (2008)
  • Author(s): 酒井徹, 小木曽真理, 中本真理子
  • Organizer: 第62回日本栄養食糧学会大会
  • Place of Presentation: 坂戸
  • Year and Date: 2008-05-04
• [Presentation] 大豆イソフラボンであるエクオールは、免疫機能にどめような影響をおよぼすのか? (2008)
  • Author(s): 酒井徹
  • Organizer: 日本栄養食糧学会
  • Place of Presentation: 坂戸市
  • Year and Date: 2008-05-03
• [Book] 公衆栄養学第2版 (2009)
  • Author(s): 酒井徹, 山本茂, 酒井徹, 郡俊之編著
• [Book] 管理栄養士技術ガイド (2008)
  • Author(s): 酒井徹, 山本茂, 小松龍史, 國井大輔編著
  • Publisher: 文光堂(東京)
• [Book] 人体栄養の基礎 (2007)
  • Author(s): 酒井徹, 小林修平, 山本茂編著
  • Publisher: 建帛社(東京)
• [Book] 「人体栄養の基礎」:第12章栄養と免疫 (2007)
  • Author(s): 酒井 徹
  • Total Pages: 11
  • Publisher: 建帛社(東京)