Development and Application of Novel Environmentally Friendly Asymmetric Organocatalysts for the Asymmetric Chemical Modification of Nitrogen Heterocycles
| Project/Area Number |
19550042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOJIMA Satoshi Hiroshima University, 大学院・理学研究科, 准教授 (70215242)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Michael付加 / 有機不斉触媒 / キラルピペラジン / フラン / 環境調和 / ジアステレオ選択性 / 特異的反応 / 置換フラン / 第4級炭素 / 8-フェニルメンチル / 酸触媒 / アルキルヒドラジン / α効果 / 分子間-1,2-付加 / 分子内-1,2-付加 / シス-4-オキソ-2-ペンテナール / 4-ジメチルアミノピリジン / フェニルアラニン / C2対称 / マイケル反応 / 触媒不斉反応 / 有機触媒 / エナンチオ選択性 |
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| Research Abstract |
Since many low molecular weight organic compounds are naturally decomposed by microorganisms and such, organic catalysts are considered environmentally friendly. In this study, a series of novel optically active nitrogen containing heterocycles were synthesized from the amino acid phenylalanine and application to the Michael addition reaction, one of the most well known carbon-carbon bond forming reactions, showed the reaction to be highly enantioselective. In addition, we have succeeded in developing a method of preparing furans, which are highly versatile as synthetic intermediates, from acyclic compounds without the use of catalysts.
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Report
(4 results)
Research Products
(85 results)
