Development of New Resins for Environmental-Friendly Kinetic Resolution of Aldol Compounds Carrying Tertiary Alcohol Units
| Project/Area Number |
19550104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Gifu University |
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Principal Investigator |
FUNABIKI Kazumasa Gifu University, 工学部, 准教授 (50273123)
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| Co-Investigator(Kenkyū-buntansha) |
KOMURA Kenichi 岐阜大学, 工学部, 准教授 (40377685)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 光学分割用樹脂 / トリフルオロメチル基 / 触媒的不斉アルドール反応 / 直接的不斉アルドール反応 / 第三級アルドール化合物 / 第二級アルドール化合物 / プロリン触媒 / 有機化学 / 有機工業化学 / 分子認識 / 光学分割 |
|---|
| Research Abstract |
独自に開発したトリフルオロメチル基を有するキラルアンカー基を修飾基に持つ新規含フッ素光学分割樹脂の合成を達成した。これを用い、第三級アルコール部位をもつアルドール化合物のラセミ体を常圧下、光学分割した。その結果、母液の光学純度は 20%ee に向上し、その値は低いものの光学分割に成功した。
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Report
(3 results)
Research Products
(28 results)
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[Book] Oxford University Press/American Chemical Society2007
Author(s)
K. Funabiki, M. Nagamori, M. Matsui, G. Raabe, and D. Enders
Publisher
Asymmetric Synthesis of β-Trifluoromethylated β-Amino Carbonyl Compounds Based on the 1, 2-Addition to Trifluoroacetaldehyde SAMPor RAMP-Hydrazone, In "Current Fluoroorganic Chemistry. New Synthetic Directions, Technologies, Materials and Biological Applications", American Chemical Society Symposium Series 949 : V. A. Soloshonok(K. Mikami, T. Yamazaki, J. T. Welch, J. Honek)
Related Report
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[Book] Oxford UniversityPress/American Chemical Society2007
Author(s)
K. Funabiki and M. Matsui
Publisher
Catalytic In-situ Generation of Trifluoroacetaldehyde from Its Hemiacetal and Successive Direct Aldol Reaction with Ketones, In "Current Fluoroorganic Chemistry. New Synthetic Directions, Technologies, Materials and Biological Applications", American Chemical Society Symposium Series 949 : V. A. Soloshonok, K.(Mikami, T. Yamazaki, J. T. Welch, J. Honek, Eds)
Related Report
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