Improvement of fracture properties of bioabsorbable polymeric composite materials by controlling molecular structures

• Project/Area Number: 19560093
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Materials/Mechanics of materials
• Research Institution: Kyushu University
• Principal Investigator: TODO Mitsugu Kyushu University, 応用力学研究所, 准教授 (80274538)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 材料設計 / プロセス / 物性 / 評価 / 生体吸収性材料 / 無機有機複合材料 / 破壊靭性 / 多孔質体 / 細胞接着性 / 骨固定材料 / 破壊特性 / 複合材料 / 分子構造 / 高次構造 / ポリマーブレンド / 高靭化

Research Abstract

生体吸収性材料として医療の分野で実用化が始まっているハイドロキシアパタイト粒子分散ポリL乳酸複合材料の破壊特性を改善するために, 分子鎖の方向を制御する方法と化学反応による架橋効果を用いる方法の2種類を考案し, どちらの方法においても効果的に破壊特性が改善されることを明らかにした. また, 生体吸収性複合材料の再生医療への応用を目指して多孔質構造体を作製し, 構造と力学特性の関係, 細胞接着性等について検討した.

Research Products

• [Journal Article] Deformation behavior and mechanism of porous PLLA under compression (2008)
  • Author(s): M. Todo, H. Kuraoka, J.W. Kim, K. Taki and M. Ohshima
  • Journal Title: Journal of Materials Science 43 Pages: 5644-5646
  • Peer Reviewed
• [Journal Article] Effect of Press Processing on Fracture Behavior of HA/PLLA Biocomposite Material (2008)
  • Author(s): M. Todo, T. Kagawa, Y. Takenoshita and A. Myoui
  • Journal Title: Journal of Solid Mechanics and Materials Engineering 2 Pages: 1-7
  • NAID: 130000078960
  • Peer Reviewed
• [Journal Article] ハイドロキシアパタイト微粒子分散ポリL乳酸の構造制御による破壊特性の向上 (2008)
  • Author(s): 東藤貢, 高山哲生
  • Journal Title: 成形加工 20 Pages: 762-768
  • NAID: 10021173206
  • Peer Reviewed
• [Journal Article] 名井陽ハイドロキシアパタイト微粒子分散ポリL乳酸の構造制御による破壊特性の向上 (2008)
  • Author(s): 加川尊, 東藤貢, 竹之下康治
  • Journal Title: 粉体および粉末冶金 55 Pages: 341-346
  • Peer Reviewed
• [Journal Article] Deformation behavior and mechanism of porous PLLA under compression (2008)
  • Author(s): Mitsugu Todo, Hiroyuki Kuraoka, Jinwoong Kim, Kentaro Taki, Masahiro Ohshima
  • Journal Title: Journal of Materials Science 43 Pages: 5644-5646
  • Peer Reviewed
• [Journal Article] Effect of Press Processing on Fracture Behavior of HA/PLLA Biocomposite Material (2008)
  • Author(s): M. Todo, T. Kagawa, Y Takenoshita, A. Myoui
  • Journal Title: Journal of Solid Mechanics and Materials Engineering 2 Pages: 1-7
  • NAID: 130000078960
  • Peer Reviewed
• [Journal Article] PLA/PCLポリマーブレンドの衝撃力学特性に及ぼす熱処理の影響 (2008)
  • Author(s): 東藤 貢, 高山哲生
  • Journal Title: 成形加工 20 Pages: 762-768
  • NAID: 10023961207
  • Peer Reviewed
• [Journal Article] ハイドロキシアパタイト微粒子分散ポリL乳酸の構造制御による破壊特性の向上 (2008)
  • Author(s): 加川 尊, 東藤 貢, 竹之下康治, 名井 陽
  • Journal Title: 粉体および粉末冶金 55 Pages: 341-346
  • NAID: 10021173206
  • Peer Reviewed
• [Journal Article] Improvement of Fracture Energy of HA/PLLA Biocomposite Material due to Press Processing Journal of Materials Science (2007)
  • Author(s): M. Todo and T. Kagawa
  • Journal Title: 43 Pages: 799-801
  • Peer Reviewed
• [Journal Article] Toughening of bioabsorbable polymer blend by microstructural modification Interface Oral Health Science 2007 (2007)
  • Author(s): M. Todo and T. Takayama
  • Pages: 95-104
  • Peer Reviewed
• [Journal Article] Relationship between Fracture Mechanism and Microstructure in PLA/PCL Polymer Blends Key Engineering Materials353-358 (2007)
  • Author(s): T. Takayama and M. Todo
  • Pages: 1169-1172
  • Peer Reviewed
• [Journal Article] Effect of LTI Blending on Fracture Proeprties of PLA/PCL Polymer Blend Journal of Solid Mechanics and Materials Engineering (2007)
  • Author(s): M. Todo
  • Journal Title: 1 Pages: 1157-1164
  • Peer Reviewed
• [Journal Article] Effect of LTI Blending on Fracture Proeprties of PLA/PCL Polymer Blend Engineering Fracture Mechanics (2007)
  • Author(s): M. Todo
  • Journal Title: 74 Pages: 1872-1883
  • Peer Reviewed
• [Journal Article] Effect of unidirectional drawing process on fracture behavior of poly(L-lactide) (2007)
  • Author(s): M. Todo
  • Journal Title: Journal of Materials Science 42 Pages: 1393-1396
  • Peer Reviewed
• [Journal Article] Improvement of Fracture Energy of HA/PLLA Biocomposite Material due to Press Processing (2007)
  • Author(s): M. Todo, et. al.
  • Journal Title: Journal of Materials Scienc 43 Pages: 799-801
  • Peer Reviewed
• [Journal Article] Toughening of bioabsorbable polymer blend by microstructural modification (2007)
  • Author(s): M. Todo, et. al.
  • Journal Title: Interface Oral Health Science 2007 Pages: 95-104
  • Peer Reviewed
• [Journal Article] Relationship between Fracture Mechanism and Microstructure in PLA/PCL Polymer Blends (2007)
  • Author(s): T. Takayama, M. Todo, et. al.
  • Journal Title: Key Engineering Materials 353-358 Pages: 1169-1172
  • Peer Reviewed
• [Journal Article] Effect of LTI Blending on Fracture Proeprties of PLA/PCL Polymer Blend (2007)
  • Author(s): M. Todo, et. al.
  • Journal Title: Journal of Solid Mechanics and Materials Engineering 1 Pages: 1157-1164
  • Peer Reviewed
• [Journal Article] Effect of LTI Blending on Fracture Proeprties of PLA/PCL Polymer Blend (2007)
  • Author(s): M. Todo, et. al.
  • Journal Title: Engineering Fracture Mechanics 74 Pages: 1872-1883
  • Peer Reviewed
• [Presentation] 海綿骨構造を模擬した吸収性多孔質体の微視構造と力学特性 (2009)
  • Author(s): 東藤貢, 倉岡宏行, 金鎮雄, 瀧健太郎, 大嶋正裕
  • Organizer: 第21回バイオエンジニアリング講演会
  • Place of Presentation: 札幌
  • Year and Date: 2009-01-23
• [Presentation] マトリックス改質によるHA/PLLA 複合材料の力学特性改善 (2008)
  • Author(s): 高山哲生, 東藤貢
  • Organizer: 第19回バイオフロンティア講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-24
• [Presentation] マトリックス改質によるHA/PLLA複合材料の力学特性改善 (2008)
  • Author(s): 高山哲生, 東藤貢
  • Organizer: 第19回バイオフロンティア講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-24
• [Presentation] LTI添加によるポリ乳酸系医用高分子の力学特性の向上 (2008)
  • Author(s): 高山哲生, 東藤貢, 名井陽, 竹之下康治
  • Organizer: 第37回医用高分子シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-07-28
• [Presentation] HA/PLLA複合材料の力学的特性に及ぼす粒子分散状態の影響 (2008)
  • Author(s): 高山哲夫, 東藤貢
  • Organizer: 第20回バイオエンジニアリング講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-25
• [Presentation] ハイドロキシアパタイト粒子分散ポリ(L-乳酸)の微視構造制御による力学特性の改善 (2007)
  • Author(s): 東藤貢
  • Organizer: 第29回日本バイオマテリアル学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-26
• [Presentation] 生体吸収性HA/PLLA複合材料の機械的特性に及ぼすLTI 添加の影響 (2007)
  • Author(s): 高山哲生, 東藤貢
  • Organizer: 第29回日本バイオマテリアル学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-26
• [Presentation] 生体吸収性HA/PLLA複合材料の機械的特性に及ぼすLTI添加の影響 (2007)
  • Author(s): 高山 哲生, 東藤 貢, 他
  • Organizer: 第29回日本バイオマテリアル学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-26
• [Presentation] Effect of Molding Condition on Fracture Characteristics of HA/PLLA nanocomposites (2007)
  • Author(s): T.Takayama and M.Todo
  • Organizer: The 6th Korea-Japan Joint Symposium on Composite Materials
  • Place of Presentation: Pohang, Korea
  • Year and Date: 2007-11-01
• [Presentation] Toughness Improvement of HA/PLLA Composites by Press Processing (2007)
  • Author(s): T.Kagawa and M.Todo
  • Organizer: The 6th Korea-Japan Joint Symposium on Composite Materials
  • Place of Presentation: Pohang, Korea
  • Year and Date: 2007-11-01
• [Presentation] Effect of Molding Condition on Fracturre Characterstics of HA/PLLA nanocomposites (2007)
  • Author(s): T. Kagawa, M. Todo
  • Organizer: The 6th Korea-Japan Joint Symposium on Composite Materials
  • Place of Presentation: Pohang, Korea
  • Year and Date: 2007-11-01
• [Presentation] Toughness Improvement of HA/PLLA Composites Press Processing (2007)
  • Author(s): T. Kagawa, M. Todo
  • Organizer: The 6th Korea-Japan Joint Symposium on Composite Materials
  • Place of Presentation: Pohang, Korrea
  • Year and Date: 2007-11-01
• [Presentation] 他ポリ(L-乳酸)の機械的特性に及ぼすイソシアネート系添加剤の影響 (2007)
  • Author(s): 高山哲生, 東藤貢
  • Organizer: M&M2007材料力学カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2007-10-25
• [Presentation] PLLA 系ポリマーブレンドの力学特性に及ぼすブレンド材の影響 (2007)
  • Author(s): 東藤貢, 倉岡宏行
  • Organizer: M&M2007材料力学カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2007-10-25
• [Presentation] HA/PLLA 複合材料のプレス加工による力学特性の改善 (2007)
  • Author(s): 東藤貢, 加川尊
  • Organizer: M&M2007材料力学カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2007-10-25
• [Presentation] ポリ(L-乳酸)の機械的特性に及ぼすイソシアネート系添加剤の影響 (2007)
  • Author(s): 高山 哲生, 東藤 貢, 他
  • Organizer: M&M2007材料力学カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2007-10-25
• [Presentation] PLLA系ポリマーブレンドの力学特性に及ぼすブレンド材の影響 (2007)
  • Author(s): 東藤 貢, 倉岡 宏行
  • Organizer: M&M2007材料力学カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2007-10-25
• [Presentation] HA/PLLA複合材料のプレス加工による力学特性の改善 (2007)
  • Author(s): 東藤 貢, 加川 尊
  • Organizer: M&M2007材料力学カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2007-10-25
• [Presentation] HA/PLLA吸収性骨固定材料の高次構造制御と力学特性 (2007)
  • Author(s): 加川 尊, 東藤 貢, 他
  • Organizer: 第18回バイオフロンティア講演会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-06
• [Presentation] Characterization of Correlation between Microstructure and Fracture Properties of Poly(Lactic Acid)Polymer Blends (2007)
  • Author(s): T.Takayama and M.Todo
  • Organizer: International Conference on Advanced Technology in Experimental Mechanics 2007
  • Place of Presentation: 福岡
  • Year and Date: 2007-09-12
• [Presentation] Characterization of Correlation between Microstructure and Fracture Properties of Poly(Lactic Acid)Polymer Blends (2007)
  • Author(s): T. Takayama, M. Todo, et. al.
  • Organizer: International Conference on Advanced Technology in Exerimental Mechanics 2007
  • Place of Presentation: 福岡
  • Year and Date: 2007-09-12
• [Presentation] Effect of Drawing on the Fracture behavior of HA/PLLA biocomposite material (2007)
  • Author(s): T.Kagawa and M.Todo
  • Organizer: Sixteenth International Conference on Composite Materials
  • Place of Presentation: 京都
  • Year and Date: 2007-07-08
• [Presentation] Effect of Nano and Micro-particles on Fracture Charactaristic of HA/PLLA composites (2007)
  • Author(s): T.Takayama and M.Todo
  • Organizer: Sixteenth International Conference on Composite Materials
  • Place of Presentation: 京都
  • Year and Date: 2007-07-08
• [Presentation] Effect of Drawing on the Fracture behavior of HA/PLLA biocomposite material (2007)
  • Author(s): T. Kagawa, M. Todo
  • Organizer: Sixteenth International Conference on CompositeMaterials
  • Place of Presentation: 京都
  • Year and Date: 2007-07-08
• [Presentation] Fracture Characterization of biodegradable PLLA polymer blends, SixteenthInternational Conference on Composite Materials (2007)
  • Author(s): M. Todo, A. Harada
  • Organizer: Sixteenth International Conference on CompositeMaterials
  • Place of Presentation: 京都
  • Year and Date: 2007-07-08
• [Presentation] Effect of Nano-and Micro-particles on Fracture Charactaristic of HA/PLLA composites (2007)
  • Author(s): T. Takayama, M. Todo, et. al.
  • Organizer: Sixteenth International Conference on CompositeMaterials
  • Place of Presentation: 京都
  • Year and Date: 2007-07-08
• [Presentation] Improvement of mechanical properties of bioabsorbable PLLA/PCL polymer blends due to P(LLA-CL)blending (2007)
  • Author(s): T.Takayama and M.Todo
  • Organizer: Third Asian Pacific Conference on Biomechanics
  • Place of Presentation: 東京
• [Presentation] Improvement of mechanical of bioabsorbable PLLA/PCL polymerblends due to P(LLA-CL)blending (2007)
  • Author(s): T. Takayama, M. Todo, et. al.
  • Organizer: Third Asian Pacific Conference on Biomechanics
  • Place of Presentation: 東京