Promotion of branching activity of epithelial tissues

• Project/Area Number: 19570054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: Chiba University
• Principal Investigator: NOGAWA Hiroyuki Chiba University, 大学院・理学研究科, 准教授 (40143250)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: マウス胚 / 唾液腺 / 肺 / 分枝形態形成 / 成長因子 / 上皮組織 / 遺伝子導入 / 分岐形態形成 / エレクトロポレーション

Research Abstract

Branching is one of fundamental patterns of morphogenesis in developing organs of mammals. In the present study we revealed that the EGF family ligand-receptor system of embryonic mouse salivary glands becomes primed by the FGF ligand-receptor system to play an important role in the induction of branching morphogenesis. We also succeeded in introducing expression vectors into embryonic mouse lung epithelial tissues.

Research Products

• [Journal Article] FGF alters epithelial competence for EGF at the initiation of branching morphogenesis of mouse submandibular gland (2009)
  • Author(s): Nitta M, Kume T, Nogawa H.
  • Journal Title: Developmental Dynamics Vol.238 Pages: 315-323
  • Peer Reviewed
• [Journal Article] FGF alters epithelial competence for EGF at the initiation of branching morphogenesis of mouse submandibular gland. (2009)
  • Author(s): Nitta M, Kuma T, Nogawa H
  • Journal Title: Developmental Dynamics 238 Pages: 315-323
  • Peer Reviewed
• [Presentation] マウス胚気管上皮の発生に伴う分枝形態形成能の低下 (2007)
  • Author(s): 松野 紘子, 安田 謙太郎, 野川 宏幸
  • Organizer: 社団法人日本動物学会第78回大会
  • Place of Presentation: 弘前大学
  • Year and Date: 2007-09-22
• [Presentation] マウス胚気管上皮の発生に伴う分枝形態形成能の低下 (2007)
  • Author(s): 松野紘子, 野川宏幸
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
• [Presentation] マウス胚唾液腺の分枝形態形成におけるEGF/FGFシグナリングの役割 (2007)
  • Author(s): 新田真理, 久米俊彰, 野川宏幸
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前