Unique urea retention system in sharks : a new approach by molecular anatomy using isolated renal nephrons
| Project/Area Number |
19570055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HYODO Susumu The University of Tokyo, 海洋研究所, 准教授 (40222244)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 軟骨魚類 / 腎臓 / 尿素 / 再吸収 / ゾウギンザメ / 輸送体 / ネフロン / 体液調節 / 環境適応 / 輸送体分子 / 分子解剖 |
|---|
| Research Abstract |
軟骨魚類が海に生きるために、体内に尿素を蓄積することは必要不可欠で、複雑な構造を持つ腎臓での尿素再吸収がそのことを可能にしている。ゾウギンザメで新規尿素輸送体を複数同定し、飼育下のドチザメでは尿素輸送体が環境浸透圧の変化によって細胞膜への集積が可逆的に制御されることを見出した。進行中の広塩性アカエイや培養系での解析とあわせ、軟骨魚類の腎機能、脊椎動物での腎機能の進化の解明に大きく貢献した。
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Report
(3 results)
Research Products
(51 results)
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[Journal Article] Molecular cloning, characterization andevolutionary analysis of estrogen receptors fromphylogenetically ancient fish2008
Author(s)
Katsu, Y., Kohno, S., Hyodo, S., Ijiri, S., Adachi, S., Hara, A., Guillette, L.J. and Iguchi, T.
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Journal Title
Endocrinology 149
Pages: 6300-6310
Related Report
Peer Reviewed
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[Journal Article] Osmoregulation in elephant fish, Callorhinchusmilii (Holocephali), with special reference to therectal gland. J2007
Author(s)
Hyodo, S., Bell, J.D., Healy J.M., Kaneko, T., Hasegawa, S., Takei, Y., Donald, J.A. and Toop, T.
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Journal Title
Exp. Biol 210
Pages: 1303-1310
Related Report
Peer Reviewed
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[Journal Article] Immuno-localization andmRNA expression of the epithelial Na+ channel α-subunit in the kidney and urinary bladder of the marine toad, Bufo marinus, underhyperosmotic conditions2007
Author(s)
Konno, N., Hyodo, S., Yamada, T., Matsuda, K. and Uchiyama, M.
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Journal Title
Cell Tissue Res 328
Pages: 583-594
Related Report
Peer Reviewed
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