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Regulation of Prox1-mediated lymphatic differentiation ofendothelial cells by transcriptional regulators

Research Project

Project/Area Number 19570176
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionThe University of Tokyo

Principal Investigator

WATABE Tetsuro  The University of Tokyo, 大学院・医学系研究科, 助教 (00334235)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords細胞分化 / 血管 / リンパ管 / ES細胞 / 再生医療 / 癌
Research Abstract

リンパ管は生体内の恒常性の維持など生理的に重要な役割を担っているとともに悪性腫瘍の転移などの病的状態にも関与している。本研究においてはProx1を中心とした転写因子のネットワークによるリンパ管分化の制御機構の包括的な解明を試みた。成果として血管内皮細胞がリンパ管内皮細胞へと分化する過程でProx1が重要な役割を果たすこと、そしてEts-2とCOUP-TFIIがリンパ管の形成と維持においてProx1と結合することにより、Prox1の機能をそれぞれ正と負の方向に調節していることが示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (32 results)

All 2009 2008 2007 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (12 results)

  • [Journal Article] TTF-1 inhibits TGF-βJournal of Cell Science.-mediatedepithelial-to-mesenchymal transition inlung adenocarcinoma cells2009

    • Author(s)
      Saito RA, Watabe T, Horiguchi K, KohyamaT, Saitoh M, Nagase T, Miyazono K.
    • Journal Title

      Cancer Research 69

      Pages: 2783-2791

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] COUP-TFIIregulates the functions of Prox1 inlymphatic endothelial cells throughdirect interaction2009

    • Author(s)
      Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T.
    • Journal Title

      Genes to Cells 14

      Pages: 425-434

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TTF-1 inhibits TGF-13-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells.2009

    • Author(s)
      Saito RA, Watabe T, Horiguchi K, Kohyama T, Saitoh M, Nagase T, Miyazono K:
    • Journal Title

      Cancer Research 69

      Pages: 2783-2791

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COUP-TFII regulates the functions of Proxl in lymphatic endothelial cells through direct interaction.2009

    • Author(s)
      Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T
    • Journal Title

      Genes to Cells 14

      Pages: 425-434

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Snail isrequired for TGFβ-inducedendothelial-mesenchymal transition ofembryonic stem cell-derived endothelialcells2008

    • Author(s)
      Kokudo T, Suzuki Y, Yoshimatsu Y,Yamazaki T, Watabe T, Miyazono K.
    • Journal Title

      Journal of Cell Science.(* : correspondingauthor) 121

      Pages: 3317-3324

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development ofstabilin2+ endothelial cells from mouseembryonic stem cells by inhibition ofTGFβ/activin signaling2008

    • Author(s)
      Nonaka H, Watabe T, Saito S, Miyazono K, Miyajima A.
    • Journal Title

      Biochemical and Biophysical Research Communications 375

      Pages: 256-260

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ras signaling directsendothelial specification of VEGFR2+vascular progenitor cells2008

    • Author(s)
      Kawasaki K, Watabe T, Sase H, HirashimaM, Koide H, Morishita Y, Yuki K, SasaokaT, Suda T, Katsuki M, Miyazono K, Miyazawa K
    • Journal Title

      Journal ofCell Biology 181

      Pages: 131-141

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition ofendogenous TGF-β signaling enhanceslymphangiogenesis2008

    • Author(s)
      Oka M, Iwata C, Suzuki H, Kiyono K, Morishita Y, Watabe T, Komuro A, Kano MR, Miyazono K
    • Journal Title

      Blood 111

      Pages: 4571-4579

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMPs promoteproliferation and migration ofendothelial cells via stimulation ofVEGF-A/VEGFR2 and Angiopoietin-1/Tie2signals2008

    • Author(s)
      Suzuki Y, Montagne K, Nishihara A, Watabe T, Miyazono K
    • Journal Title

      Journal of Biochemistry(* : corresponding author) 143

      Pages: 199-206

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of PSCA increases metastasis ofTRAMP-induced prostate tumors withoutaltering primary tumor formation2008

    • Author(s)
      Moore ML, Teitell MA, Kim Y, Watabe T, Reiter RE, Witte ON, Dubey P
    • Journal Title

      Prostate 68

      Pages: 139-151

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Snail is required for TGFβ-induced endothelial-mesenchymal transition of embryonic, stem cell-derived endothelial cells.2008

    • Author(s)
      Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, Watabe T. Miyazono
    • Journal Title

      Journal of Cell Science 121

      Pages: 3317-3324

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of stabilin2+ endothelial cells from mouse embryonic stemcells by inhibition of TGFβ/activin signaling.2008

    • Author(s)
      Nonaka H, Watabe T, Saito S, Miyazono K, Miyajima A
    • Journal Title

      Biochemical and Biophysical Research Communications 375

      Pages: 56-260

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells2008

    • Author(s)
      Kawasaki K, Watabe T, Sase H, Hirashima M, Koide H, Morishita Y, Yuki K, Sasaoka T, Suda T, Katsuki M, Miyazono K, Miyazawa K.
    • Journal Title

      Journal of Cell Biology 181

      Pages: 131-141

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of endogenous TGF-13 signaling enhances lymphangiogenesis2008

    • Author(s)
      Oka M, Iwata C, Suzuki H, Kiyono K, Morishita Y, Watabe T, Komuro A, Kano MR, Miyaono K.
    • Journal Title

      Blood 111

      Pages: 4571-4579

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-ANEGFR2 and Angiopoietin-1/Tie2 signals.2008

    • Author(s)
      Suzuki Y, Montagne K, Nishihara A, Watabe T, Miyazono K.
    • Journal Title

      Journal of Biochemistry 143

      Pages: 199-206

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMPs promote proliferation and migratin of endothelial cells via stimulation of VEGF-A/VEGFR2 and Angiopoietin-1/Tie2 signals2008

    • Author(s)
      Suzuki Y, Montagne K, Nishihara A, Watabe T, Miyazono K.
    • Journal Title

      Journal of Biochemistry 143

      Pages: 199-206

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of endogenous TGF-β signaling enhances lymphangiogensis2008

    • Author(s)
      Oka M, Iwata C, Suzuki H, kiyono K, Morishita Y, Watabe T, Komuro A, Kano MR, Miyazono K
    • Journal Title

      Blood (印刷中)(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proxlinduces lymphatic endothelialdifferentiation via integrin α9 andother signaling cascades2007

    • Author(s)
      Mishima K, Watabe T, Saito A, YoshimatsuY, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, Niwa H, KuboH, Suda T, Miyazono K.
    • Journal Title

      MolecularBiology of the Cell 18

      Pages: 1421-1429

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activin-Nodal signaling is involved inpropagation of mouse embryonic stemcells2007

    • Author(s)
      Ogawa K, Saito A, Matsui H, Suzuki H,Ohtsuka S, Shimosato D, Morishita Y, Watabe T, Niwa H, Miyazono K.
    • Journal Title

      Journal of Cell Science 120

      Pages: 55-65

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proxl induces Iymphatic endothelial differentiation via integrin α9 and other signaling casca2007

    • Author(s)
      Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, Niwa H, Kubo H, Suda T, Miyazono K
    • Journal Title

      Molecular Biology of the Cell 18

      Pages: 1421-1429

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Snail is required forTGF-β-induced endothelial-mesenchymaltransition of embryonic stem cell-derivedendothelial cells2008

    • Author(s)
      Watabe T, Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, Miyazono K.
    • Organizer
      第16回日本血管生物医学会
    • Place of Presentation
      金沢・石川県立音楽堂交流ホール
    • Year and Date
      2008-12-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Snail is required for TGF-β-inducedendothelial-mesenchymal transition ofembryonic stem cell-derived endothelialcells2008

    • Author(s)
      Watabe T, Kokudo T, Suzuki Y, YoshimatsuY, Yamazaki T, Mihira H, Miyazono K.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋・名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Snail is required for TGF-β-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells2008

    • Author(s)
      Watabe T, Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, Mihira H, Miyazono K
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] リンパ管発生における転写・シグナルネットワークの役割2008

    • Author(s)
      渡部徹郎
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      都市センターホテル、東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] リンパ管発生における転写・シグナルネットワークの役割2008

    • Author(s)
      渡部徹郎
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京・都市センターホテル
    • Year and Date
      2008-07-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Roles of Etsfamily members in the regulation ofProxl-mediated lymphaticdifferentiation of endothelial cells2008

    • Author(s)
      Watabe T, Yoshimatsu Y, Yamazaki T, Morikawa M, Miyazono K.
    • Organizer
      The 15^<th> International Vascular BiologyMeeting
    • Place of Presentation
      Sydney Convention, Exhibition Centre, Sydney, Australia
    • Year and Date
      2008-06-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Roles of Ets family members in the regulation of Proxl-mediated lymphatic differentiation of endothelial cells.2008

    • Author(s)
      Watabe T, Yoshimatsu Y, Yamazaki T, Morikawa M, Miyazono K.
    • Organizer
      The 15th International Vascular Biology Meeting
    • Place of Presentation
      Sydney Convention & Exhibition Centre, Sydney, Australia
    • Year and Date
      2008-06-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of Prox1-mediated lymphaticdifferentiation of endothelial cells bytranscriptional regulators2008

    • Author(s)
      Watabe, T., Yoshimatsu, Y., Yamazaki, T., Morikawa, M., Miyazono, K.
    • Organizer
      TheU.S. -Japan Cooperative Cancer Research Program Workshop
    • Place of Presentation
      京都・京都ガーデンパレス
    • Year and Date
      2008-03-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of Prox1-mediated lymphatic differentiation of endothelial cells by transcriptional regulators2008

    • Author(s)
      Watabe, T., Yoshimatsu, Y., Yamazaki, T., Morikawa, M., and Miyazono, K.
    • Organizer
      The U.S.-Japan Cooperative Cancer Resarch Program Workshop
    • Place of Presentation
      京都
    • Year and Date
      2008-03-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Snail is required for TGF-β-inducedendothelial-mesenchymal transition ofembryonic stem cell-derived endothelialcells2008

    • Author(s)
      Watabe T, Kokudo T, Suzuki Y, YoshimatsuY, Yamazaki T, Mihira H, Miyazono K.
    • Organizer
      The 28^<th> Sapporo Cancer SeminarInternational Symposium"TGF-βsignaling and cancer"
    • Place of Presentation
      札幌・北海道大学 学術交流会館大講堂
    • Related Report
      2008 Final Research Report
  • [Presentation] Snail is required for TGF-13-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells2008

    • Author(s)
      Watabe T, Kokudo T, Suzuki Y, Y oshimatsu Y, Yamazaki T, Mihira H, Miyazono K
    • Organizer
      The 28th Sapporo Cancer Seminar International Symposium "TGF-β signaling and cancer"
    • Place of Presentation
      北海道大学学術交流会館大講堂、札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] Snail is required for TGF-β-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells

    • Author(s)
      Watabe T, Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, Mihira H, Miyazono K
    • Organizer
      第16回日本血管生物医学会
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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