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Membrane trafficking mechanism of HB-EGF from the plasma membrane to the nuclear membrane

Research Project

Project/Area Number 19570182
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionOsaka University (2008)
Ehime University (2007)

Principal Investigator

HIEDA Miki  Osaka University, 大学院・医学系研究科, 特任助教 (00380254)

Co-Investigator(Kenkyū-buntansha) MATSUURA Nariaki  大阪大学, 大学院・医学系研究科, 教授 (70190402)
東山 繁樹  愛媛大学, 大学院・医学系研究科, 教授 (60202272)
Co-Investigator(Renkei-kenkyūsha) HIGASHIYAMA Shigeki  愛媛大学, 大学院・医学系研究科, 教授 (60202272)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsメンブレントラフィック / HB-EGF / EGF 増殖因子 / 核膜 / EGFファミリー / 細胞増殖
Research Abstract

上皮増殖因子 (EGF) ファミリー分子 は膜貫通型タンパク質として細胞膜に発現し、細胞外領域の切断により増殖因子を細胞外へ遊離する。この時、細胞膜には膜貫通型ペプチド断片が残る。私達はEGF ファミリーメンバー、HB-EGF の膜貫通型ペプチド断片が細胞膜から核膜内膜へ局在変化し、転写因子に結合し、転写調節を行う事を明らかにした。 さらにHB-EGF だけでなく、他のEGF 分子、amphiregulin も細胞膜から核膜へ局在変化する事を示した。この時、カルボキシル末端が切断され、核膜裏打ちタンパク質ラミンと結合する事、核膜局在化によりヒストンH3 の修飾が変化し、グローバルな転写が一時的に抑制される事も明らかにした

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (68 results)

All 2009 2008 2007

All Journal Article (38 results) (of which Peer Reviewed: 38 results) Presentation (30 results)

  • [Journal Article] Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury2009

    • Author(s)
      Oya S, Yoshikawa G, Takai K, Tanaka JI,Higashiyama, S., Saito N, Kirino T,Kawahara N.
    • Journal Title

      Neuroscience 158

      Pages: 683-692

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insufficient shedding of proHB-EGF enhances hypoxic cell death in H9c2 cardiomyoblasts via activation of Caspase-3 and c-Jun N-terminal kinase2009

    • Author(s)
      Uetani, T., Nakayama, H., Okayama, H.,Okura T., Higaki, J., Inoue, H., &Higashiyama, S.
    • Journal Title

      J.Biol. Chem (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid diagnosis of lymph node metastasis in lung cancer with loop-mediated isothermal amplification assay using carcinoembryonic antigen-Mrna2009

    • Author(s)
      Maeda J, Inoue M, Nakabayashi K,Otomo Y, Shintani Y, Ohta M, Okumura M,Matsuura, N.
    • Journal Title

      Lung Cancer (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-angiogenic and anti-metastatic effects of β-1,3-glucan purified from Hanabiratake, Sparassis crispa2009

    • Author(s)
      Yamamoto, K., Kimura, T., Sugitachi, A.,Matsuura, N.
    • Journal Title

      Biological & Pharmaceutical Bulletin 32

      Pages: 259-263

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation2009

    • Author(s)
      Miyagawa, S., Matsumiya, G., Funatsu, T.,Yoshitatsu, M., Sekiya, N., Fukui, S.,Hoashi, T., Hori, M., Yoshikawa, H.,Kanakura, Y., Ishikawa, J., Aozasa, K.,Kawaguchi, N., Matsuura, N., Myoui, A.,Matsuyama, A., Ezoe, S., Iida, H.,Matsuda, H., Sawa, Y.
    • Journal Title

      Report of a case. Surg 39

      Pages: 133-136

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The plasma membrane-anchored growth factor, pro-amphiregulin, binds A-type lamin and regulates global transcription2008

    • Author(s)
      Isokane, M., Hieda, M., Hirakawa, S.,Shudou, M., Nakashiro, K., Hashimoto, K., Hamakawa, H., and Higashiyama, S.
    • Journal Title

      J. Cell. Sci 121

      Pages: 3608-3618

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-anchored growth factor,HB-EGF, on the cell surface targeted to the inner nuclear membrane2008

    • Author(s)
      Hieda, M., Isokane, M., Koizumi, M.,Higashi, C., Tachibana, T., Shudou, M.,Taguchi, T., Hieda, Y., and Higashiyama, S.
    • Journal Title

      J. Cell Biol 180

      Pages: 763-769

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-anchored Growth Factors, The EGF Family : Beyond receptor ligands2008

    • Author(s)
      Higashiyama, S., Iwabuki, H., Morimoto,C., Hieda, M., Inoue, H., and Matsushita, N.
    • Journal Title

      Cancer Sci 99

      Pages: 214-220

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localized regulation of axonal RanGTPase controls retrograde injury signalingin peripheral nerve2008

    • Author(s)
      Yudin, D., Hanz S.,Yoo,S., Iavnilovitch,E., Willis,D., Gradus, T., Vuppalanchi,D.,Segal-Ruder,Y., Ben-Yaakov, K., Hieda,M., Yoneda, Y., Twiss, J.L., andFainzilber, M.
    • Journal Title

      Neuron 59

      Pages: 241-252

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Region-specific proliferative response of neural progenitors to exogenous stimulation by growth factors following ischemia2008

    • Author(s)
      Oya S, Yoshikawa G, Takai K, Tanaka JI,Higashiyama, S., Saito N, Kirino T,Kawahara N.
    • Journal Title

      Neuroreport 19

      Pages: 805-809

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells2008

    • Author(s)
      Ngan, C.Y., Yamamoto, H., Takagi, A.,Fujie, Y., Takemasa, I., Ikeda, M.,Takahashi-Yanaga, F., Sasaguri, T.,Sekimoto, M., Matsuura, N., Monden, M.
    • Journal Title

      Cancer Sci 99

      Pages: 129-139

    • NAID

      10024001242

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression of colorectal cancer : Preoperative genetic diagnosis using endoscopic biopsies. Int.2008

    • Author(s)
      Komori, T., Takemasa, I., Yamasaki, M.,Motoori, M., Kato, T., Kikkawa, N.,Kawaguchi, N., Ikeda, M., Yamamoto, H.,Sekimoto, M., Matsubara, K., MatsuuraN., Monden, M.
    • Journal Title

      J. Oncol 32

      Pages: 367-375

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of L-plastin autoantibody in plasma of patients with non-Hodgkin's lymphoma using a proteomics-based analysis2008

    • Author(s)
      Ueda, K., Nakanishi, T., Shimizu, A.,Takubo, T., Matsuura, N.
    • Journal Title

      Ann Clin Biochem 45

      Pages: 65-69

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer2008

    • Author(s)
      Ezumi, K., Yamamoto, H., Murata, K.,Higashiyama, M., Damdinsuren, B.,Nakamura, Y., Kyo, N., Okami, J., Ngan,C.Y., Takemasa, I., Ikeda, M., Sekimoto,M., Matsuura, N., Nojima, H., Monden, M.
    • Journal Title

      Clin. Cancer Res 14

      Pages: 677-684

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of midkine on cardiac remodeling in infarcted rat hearts2008

    • Author(s)
      Fukui, S., Kitagawa-Sakakida, S.,Kawamata, S., Matsumiya, G., Kawaguchi,N., Matsuura, N., Sawa, Y.
    • Journal Title

      Ann. Thorac. Surg 85

      Pages: 562-570

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topoisomerase IIalpha-positive and BRCA1-negative phenotype : Association with favorable response to epirubicin-based regimens for human breast cancers2008

    • Author(s)
      Miyoshi, Y., Kurosumi, M., Kurebayashi, J.,Matsuura, N., Takahashi, M., Tokunaga,E., Egawa, C., Masuda, N., Kim, S.J.,Okishiro, M., Yanagisawa, T., Ueda, S.,Taguchi, T., Tamaki, Y., Noguchi, S.
    • Journal Title

      Cancer Lett 264

      Pages: 44-53

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data2008

    • Author(s)
      17. Kittaka, N., Takemasa, I., Takeda, Y.,Marubashi, S., Nagano, H., Umeshita, K.,Dono, K., Matsubara, K., Matsuura, N.,Monden, M.
    • Journal Title

      Eur.J. Cancer 44

      Pages: 885-897

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society. Low nuclear grade but not cell proliferation predictive of pathological complete response to docetaxel in human breast cancers2008

    • Author(s)
      18. Miyoshi, Y., Kurosumi, M., Kurebayashi, J.,Matsuura, N., Takahashi, M., Tokunaga,E., Egawa, C., Masuda, N., Kim, S.J.,Okishiro, M., Yanagisawa, T., Ueda, S.,Taguchi, T., Tamaki, Y., Noguchi, S.
    • Journal Title

      J. Cancer Res. Clin.Oncol 134

      Pages: 561-567

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice.2008

    • Author(s)
      Shiozaki, M., Yoshimura, K., Shibata, M.,Koike, M., Matsuura, N., Uchiyama, Y.,Gotow, T.
    • Journal Title

      Neuroscience 152

      Pages: 924-941

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma : A novel approach for biomarker discovery2008

    • Author(s)
      Watanabe, M., Takemasa, I., Kawaguchi,N., Miyake, M., Nishimura, N., Matsubara,T., Matsuo, E., Sekimoto, M., Nagai, K.,Matsuura, N., Monden, M., Nishimura, O.
    • Journal Title

      Proteomics Clin 2

      Pages: 925-935

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A self-renewing, tissue-engineered vascular graft for arterial reconstruction2008

    • Author(s)
      Torikai, K., Ichikawa, H., Hirakawa, K.,Matsumiya, G., Kuratani, T., Iwai, S., Saito,A., Kawaguchi, N., Matsuura, N., Sawa, Y.
    • Journal Title

      J.Thorac Cardiovasc Surg 136

      Pages: 37-45

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The implication of N-acetylglucosaminyltransferase V expression in gastric cancer2008

    • Author(s)
      Tian, H., Miyoshi, E., Kawaguchi, N.,Shaker, M., Ito, Y., Taniguchi, N.,Tsujimoto, M., Matsuura, N.
    • Journal Title

      Pathobiology 75

      Pages: 288-294

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of occult lymph node metastasis in lung cancer patients using molecular technique2008

    • Author(s)
      Inoue, M., Maeda, J., Ohta, M., Sawabata,N., Matsuura, N., Okumura, M.
    • Journal Title

      Curr. Res. in Cancer 2

      Pages: 141-149

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ tissue regeneration using a novel tissue-engineered, small-caliber vascular graft without cell seeding2008

    • Author(s)
      Yokota, T., Ichikawa, H., Matsumiya, G.,Kuratani, T., Sakaguchi, T., Iwai, S.,Shirakawa, Y., Torikai, K., Saito, A.,Uchimura, E., Kawaguchi, N., Matsuura,N., Sawa, Y.
    • Journal Title

      J. Thorac Cardiovasc Surg 136

      Pages: 900-907

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells2008

    • Author(s)
      Yamamoto, H., Noura, S., Okami, J.,Uemura, M., Takemasa, I., Ikeda, M., Ishii, H., Sekimoto, M., Matsuura, N., Monden, M., Mori, M.
    • Journal Title

      Int. J. Mol. Med. 22

      Pages: 757-761

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane anchored-growth factor, HB-EGF on the cell surface targeted to the inner nuclear membrane2008

    • Author(s)
      Hieda, et al.
    • Journal Title

      Journal of Cell Biology 180

      Pages: 763-769

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The plasma membrane-anchored growth factor, pro-amphiregulin, binds A-type lam in and regulates global transcription2008

    • Author(s)
      Isokane, et al.
    • Journal Title

      Journal of Cell Science 121

      Pages: 3608-3618

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-anchored growth factors, the EGF tamily. Beyond receptor ligands.2008

    • Author(s)
      Higashiyama, et al.
    • Journal Title

      Cancer Science 211

      Pages: 214-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localized regulation of axonal RanGTPase controls retrogradeinjury signalingin peripheral nerve2008

    • Author(s)
      Yudin, et al.
    • Journal Title

      Neuron 59

      Pages: 241-252

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane anchored-growth factor,HB-EGF on the cell surface targeted to the inner nuclear membrane2008

    • Author(s)
      Hieda, et. al.
    • Journal Title

      Journal of Cell Biology 180

      Pages: 763-769

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-anchored growth factors,the EGF family.Beyond receptor lig ands2008

    • Author(s)
      Higashiyama, et. al.
    • Journal Title

      Cancer Science 99

      Pages: 214-220

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The carboxyl-terminal fragment of proHB-EGF reverses Bcl6-mediated gene repression2007

    • Author(s)
      Kinugasa, Y., Hieda, M., Hori, M., and Higashiyama, S.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 14797-14806

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pbx1is a major target of PLZF-mediated melanoma cell growth suppression2007

    • Author(s)
      Shiraishi, K., Yamasaki, K., Nanba, D.,Inoue, H., Hanakawa, Y., Shirakata, Y.,Hashimoto, K., and Higashiyama, S.
    • Journal Title

      Oncogene 26

      Pages: 339-348

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] and Higashiyama, S. Effects of promyelocytic leukemia zinc finger protein on the proliferation of cultured human corneal endothelial cells2007

    • Author(s)
      Joko, T., Nanba, D., Shiba, F., Miyata, K., Shiraishi, A., Ohashi, Y.
    • Journal Title

      Mol. Vision 13

      Pages: 649-658

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An intermediary role of proHB-EGF shedding in growth factor-induced c-myc expression2007

    • Author(s)
      Nanba, D., Inoue, Y., Shigemi, Y., Shirakata, Y., Hashimoto, K., and Higashiyama, S.
    • Journal Title

      J.Cell.Physiol 214

      Pages: 465-473

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts2007

    • Author(s)
      Furochi, H., Tamura, S., Mameoka, M.,Yamada, C., Ogawa, T., Hirasaka, K.,Okumura, Y., Imagawa, T., Oguri, S.,Ishidoh, K., Kishi, K., Higashiyama, S.Nikawa, T.
    • Journal Title

      FEBS Lett 581

      Pages: 5743-5750

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members2007

    • Author(s)
      Morita, S., Shirakata, Y., Shiraishi, A.Kadota, Y., Hashimoto , K., Higashiyama,S., Ohashi, Y.
    • Journal Title

      Mol. Vision 13

      Pages: 2119-2128

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding2007

    • Author(s)
      Ikin, A.F., Causevic, M., Pedrini, S.,Lyndsey S. Bensonl, L.S., Buxbaum, J.D.,Suzuki, T., Simon Lovestone, S.,Higashiyama, S., Mustelin, T., Burgoyne, R.D., and Gandy, S.
    • Journal Title

      Molecular Neurodegeneration 2, 23

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Nuclear signaling of membrane-anchored growth factors and cell growth regulation2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      International Symposium "New Frontiers in Cancer Research"
    • Place of Presentation
      Sapporo, Hokkaido
    • Year and Date
      2009-03-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      Gordon Research Conference "Signal Transduction within the Nucleus"
    • Place of Presentation
      Ventura, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Inner nuclear membrane targeting of pro-amphiregulin regulatesoral squamous cell carcinoma cell viability2008

    • Author(s)
      Miki Hieda
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      愛知県・名古屋市 名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Plasma membrane anchored growth factors HB-EGF and mamphiregulin targeted to the inner nuclear membrane and regulate gene expression2008

    • Author(s)
      Miki Hieda
    • Organizer
      Cold Spring Harbar meeting, Nuclear structure and function Dynamic Organization of Nuclear Function
    • Place of Presentation
      Cold Spring Harbar, NY, U.S.A.
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intracellular transport of membrane-anchored EGF family growthfactor from the plasma membrane to the inner nuclear membrane2008

    • Author(s)
      Miki Hieda
    • Organizer
      60回日本細胞生物学会大会
    • Place of Presentation
      神奈川県・パシフィコ横浜
    • Year and Date
      2008-07-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] The plasma membrane-anchored growth factor, amphiregulin, binds A-ype lamin and regulates global transcription2008

    • Author(s)
      Mayumi Isokane
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      神奈川県・パシフイコ横浜
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mayumi Isokane, Miki Hieda, Satoshi Hirakawa, Koichi Nakashiro, Koji Hashimoto, Hiroyuki Hamakawa and Shigeki Higashiyama The plasma membrane-anchored growth factor, amphiregulin, binds A-type lamin and regulates global transcription2008

    • Author(s)
      Mayumi Isokane
    • Organizer
      12th International Congress on Oral Cancer conjunction with 24th Congress of ICMFS (former IAMFS)
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膜型増殖因子の核膜内膜移行による転写調節2008

    • Author(s)
      東山繁樹
    • Organizer
      特定領域研究「核ダイナミクス」「遺伝情報デコード」合同シンポジウム「クロマチンシグナリングの分子機構」
    • Place of Presentation
      東京ステーションカンファレンス
    • Year and Date
      2008-01-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Inner nuclear membrane targeting of pro-amphiregulin regulates oral squamous cell carcinoma cell viability2008

    • Author(s)
      Mayumi Isokane, Miki Hieda, Eriko Koya, Koichi Nakashiro, Hiroyuki Hamakawa and Shigeki Higashiyama
    • Organizer
      第67回日本癌学会学術総会 (ミニシンポジウム・口頭発表)
    • Place of Presentation
      愛知県・名古屋市
    • Related Report
      2008 Final Research Report
  • [Presentation] Induction of Metastatic Potential by Cleavage of Carcinoembryonic Antigen in Colorectal Carcinoma Cells2008

    • Author(s)
      Kaori Iwaki, Yasuko Yamamoto, Yukiko Ueno, Yuhki Yokoyama, Mohammed N.Shaker, Seiji Mori, Nariaki Matsuura
    • Organizer
      36th Congress of the International Society of Oncology & Biomarkers
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Final Research Report
  • [Presentation] Novel Molecular Method for Rapid Diagnosis of Lymph Node Metastasis in Breast Cancer2008

    • Author(s)
      Mohammed N.Shaker, Seiji Mori, Yuhki Yokoyama, Kaori Iwaki, Yukiko Ueno,Nariaki Matsuura
    • Organizer
      36th Congress of the International Society of Oncology & Biomarkers
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Final Research Report
  • [Presentation] Intermediate Surrogate Molecular Marker for the Prevention of Colorectal Cancer2008

    • Author(s)
      Yukiko Ueno, Hideki Ishikawa, Yuhki Yokoyama, Mohammed N. Shaker, KaoriIwaki, Seiji Mori, Nariaki Matsuura
    • Organizer
      36th Congress of the International Society of Oncology & Biomarkers
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Final Research Report
  • [Presentation] Specific Binding of Fibroblast Growth Factor-1 (FGF1) to Integrins is Required for FGF1 Signaling2008

    • Author(s)
      Seiji Mori, Yoshikazu Takada, Nariaki Matsuura
    • Organizer
      36th Congress of the International Society of Oncology & Biomarkers
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of Platelet Derived Growth Factor on Development and Progression of Breast Cancer2008

    • Author(s)
      Yuhki Yokoyama, Seiji Mori, Nariaki Matsuura
    • Organizer
      36th Congress of the International Society of Oncology & Biomarkers
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Final Research Report
  • [Presentation] Plasma membrane anchored growth factors HB-EGF and mamphiregulin targeted to the inner nuclear membrane and regulate gene expression2008

    • Author(s)
      Mayumi Isokane, Miki Hieda, and Shigeki Higashiyama
    • Organizer
      Cold Spring Harbar meeting, Nuclear structure and function Dynamic Organization of Nuclear Function (ポスタ ー発表)
    • Place of Presentation
      Cold Spring Harbar, NY, U.S.A.
    • Related Report
      2008 Final Research Report
  • [Presentation] Intracellular transport of membrane-anchored EGF family growth factor from the plasma membrane to the inner nuclear membrane 「膜型増殖因子EGF ファミリー分子は細胞膜から核膜へ局在変化する」2008

    • Author(s)
      檜枝美紀、礒兼真由美、東山繁樹
    • Organizer
      第60回日本細胞生物学会
    • Place of Presentation
      神奈川県・パシフィコ横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] The plasma membrane-anchored growth factor, amphiregulin, binds A-type lamin and regulates global transcription 「膜型増 殖因子amphiregulin の細胞内輸送経路およびその機能解析」2008

    • Author(s)
      礒兼真由美、檜枝美紀、東山繁樹
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] The plasma membrane-anchored growth factor, amphiregulin, binds A-type lamin and regulates global transcription2008

    • Author(s)
      Mayumi Isokane, Miki Hieda, Satoshi Hirakawa, Koichi Nakashiro, Koji Hashimoto, Hiroyuki Hamakawa and Shigeki Higashiyama
    • Organizer
      12th International Congress on Oral Cancer conjunction with 24th Congress of ICMFS (former IAMFS)
    • Place of Presentation
      Shanghai, China
    • Related Report
      2008 Final Research Report
  • [Presentation] The Role of ADAM9 in Metastasis of Non-Small Cell Lung Cancer2008

    • Author(s)
      Nariaki Matsuura, Yasushi Shintani, Yukiko Ueno, Kaori Iwaki, Yuhki Yokoyama, Mohammed N.
    • Organizer
      Shaker, Seiji Mori. 36th Congress of the International Society of Oncology & Biomarkers, Symposium "New Molecular Markers in Lung Cancer"
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of a new molecular method for rapid diagnosis of lymph node metastasis in breast cancer2008

    • Author(s)
      N. Matsuura, F. Akiyama, S. Noguchi, M. Tsujimoto, H. Inaji, S. Nakamura, M. Mano, Y.
    • Organizer
      Otomo, International Oncoplastic Breast Surgery Symposium,
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] 膜型増殖因子の核膜内膜移行とがん細胞特性の変化2008

    • Author(s)
      東山繁樹
    • Organizer
      文部科学省, 厚生労働省がん研究合同シンポジウム
    • Place of Presentation
      学術総合センター一橋記念講堂(東京)、招待講演
    • Related Report
      2008 Final Research Report
  • [Presentation] 膜型増殖因子による遺伝子転写制御機構(招待講演)2007

    • Author(s)
      東山繁樹
    • Organizer
      第44回日本口腔組織培養学会
    • Place of Presentation
      松山
    • Year and Date
      2007-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 癌微小環境における細胞特性の変化-膜型増殖因子の役割(招待講演)2007

    • Author(s)
      東山繁樹
    • Organizer
      第59回日本泌尿器科学会西日本総会
    • Place of Presentation
      松山
    • Year and Date
      2007-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda and Shigeki Higashiyama
    • Organizer
      国際シンポジウム「メンブレントラフィック」
    • Place of Presentation
      淡路島
    • Related Report
      2008 Final Research Report
  • [Presentation] 「膜型増殖因子HB-EGFは核膜内膜に移行し転写を調節する2007

    • Author(s)
      檜枝美紀、衣笠由美、東山繁樹
    • Organizer
      核ダイナミクス研究会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda and Shigeki Higashiyama
    • Organizer
      EMBO Conference Series on Nuclear Structure and Dynamics Montpellier
    • Related Report
      2008 Final Research Report
  • [Presentation] Membrane-anchored growth factor, HB-EGF targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda, Yumi Kinugasa, Chizuru Higashi, Taro Tachibana, Tomohiko Taguchi, and Shigeki Higashiyama
    • Organizer
      第40回発生生物学会第49回日本細胞生物学会合同大会
    • Place of Presentation
      福岡県福岡市国際会議場
    • Related Report
      2008 Final Research Report
  • [Presentation] Membrane-anchored growth factor, HB-EGF targets tothe nuclear membrane and regulates gene expression2007

    • Author(s)
      Hieda M, Kinugasa Y, Higashi C., Tachibana T, Taguchi T., and Higashiyama S.
    • Organizer
      第40回発生生物学会第49回日本細胞生物学会合同大会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membra ne and regulates gene expression2007

    • Author(s)
      Hieda M, and Higashiyama S.
    • Organizer
      EMBO Conference Series on Nuclear Structure and Dynamics
    • Place of Presentation
      フランス モンペリエ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Membrance-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Hieda M, and Higashiyama S.
    • Organizer
      国際シンポジウム「メンブレントラフィック」
    • Place of Presentation
      兵庫県洲本町
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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