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Regulation of cell polarization by RAPL-Mst1 signaling

Research Project

Project/Area Number 19570188
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionKansai Medical University

Principal Investigator

KATAGIRI Koko  Kansai Medical University, 医学部, 准教授 (00322157)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords細胞内・細胞間情報伝達 / インテグリン / 接着 / 遊走 / PAPL / Mst1 / 小胞輸送 / RAPL
Research Abstract

免疫細胞の活発な生体内移動の基盤であるインテグリンを介する接着および遊走を制御する低分子量Gタンパク質Rap1会合分子RAPLの下流で、Mst1が細胞極性の形成に重要な役割を果たすことを見出した。Mst1のノックアウトマウスを作製し、免疫細胞の動態への影響をin vitro及びin vivoで定量解析し、Mst1がケモカインを介する極性形成や遊走に重要な働きをすることを明かにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2009 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results)

  • [Journal Article] Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes2009

    • Author(s)
      K.Katagiri , T. Katakai , Y. Ebisuno , Y. Ueda, T. Okada, T. Kinashi
    • Journal Title

      EMBO J. 6

      Pages: 1319-1331

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organizer-like reticular stromal cell layer common adult secondary lymphoid organs2008

    • Author(s)
      T. Katakai , H. Suto, M. Sugai, H. Gonda, A.Togawa , S. Suematsu, Y. Ebisuno, K. Katagiri, T. Kinashi, A. Shimizu
    • Journal Title

      J.Immunol. 181

      Pages: 6189-6200

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organizer-like reticular stromal cell layer common adult secondary lymphoid organs.2008

    • Author(s)
      Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Sumeatsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A.
    • Journal Title

      J. Immunol. 81

      Pages: 6189-6200

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The M-Ras-RA-GEF2-Rap1 pathway nediates tumor necrosis factor-α-dependent regulation of integrin activation in splenocytes2007

    • Author(s)
      Katagiri K
    • Journal Title

      MCB 18

      Pages: 2949-59

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mst1 controls lymphocyte trafficking and interstitial motility with in lymph nodes.

    • Author(s)
      Katagiri, K, Katakai T, Ebisuno Y, Ueda Y, Okada T, Kinashi T.
    • Journal Title

      EMBO J (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes2008

    • Author(s)
      片桐 晃子, 他
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Mst1 controls lymphocyte trafficking and interstitial motility with in lymph nodes.2008

    • Author(s)
      片桐晃子
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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