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Elucidation of degrading processes of polyunsaturated fatty acids by introducing a gene encoding polyhydroxyalkanoate synthase

Research Project

Project/Area Number 19580080
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied microbiology
Research InstitutionUtsunomiya University

Principal Investigator

MAEDA Isamu  Utsunomiya University, 農学部, 准教授 (10252701)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords不飽和脂肪酸 / ポリヒドロキシアルカン酸 / オレイン酸 / リノール酸 / リノレン酸 / 酵母 / Saccharomyces cerevisiae / β-酸化 / Saccharomyces cervisiae
Research Abstract

When a polyunsaturated fatty acid contains the 12-cis double bond, dienoyl-CoA reductase activity has been shown to play an important role in β-oxidation of the fatty acid. As both linoleic acid and α-linolenic acid contain the 9-cis and 12-cis double bonds, it was suggested in α-linolenic acid that its inhibitory effect on β-oxidation and the higher necessity of dienoyl-CoA reductase activity in its metabolism might be due to the existence of 15-cis double bond.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Remarks (3 results)

  • [Journal Article] Genetic replacement of tesB with PTE1 affects chain-length proportions of 3-hydroxyalkanoic acids produced through β-oxidation of oleic acid in Escherichia coli2010

    • Author(s)
      Yoshiaki Seto, Junkyu Kang, Li Ming, Naoto Habu, Ken-ichi Nihei, Shunsaku Ueda, Isamu Maeda
    • Journal Title

      Journal of Bioscience and Bioengineering (in press)

    • NAID

      110007880134

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic replacement of tesB with PTE1 affects chain-length proportions of 3-hydroxyalkanoic acids produced through β-oxidation of oleic acid in Escherichia coli2010

    • Author(s)
      Yoshiaki Seto, Junkyu Kang, Li Ming, Naoto Habu, Ken-ichi Nihei, Shunsaku Ueda, Isamu Maeda
    • Journal Title

      Journal of Bioscience and Bioengineering (印刷中)

    • NAID

      110007880134

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 出芽酵母を用いた多価不飽和脂肪酸β-酸化過程の解明2009

    • Author(s)
      高浜由実, 上田俊策, 前田勇
    • Organizer
      日本農芸化学会関東支部2009年度大会
    • Place of Presentation
      東京都町田市 玉川大学視聴覚センター
    • Year and Date
      2009-10-31
    • Related Report
      2009 Final Research Report
  • [Presentation] 出芽酵母を用いた多価不飽和脂肪酸β-酸化過程の解明2009

    • Author(s)
      高浜由実、上田俊策、前田勇
    • Organizer
      日本農芸化学会関東支部2009年度大会
    • Place of Presentation
      玉川大学 視聴覚センター
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] アシル-CoAチオエステラーゼII (TesB) ファミリー酵素のβ-酸化中間体に対する基質特異性の解析2008

    • Author(s)
      瀬戸慶彬, 長谷川晴子, 上田俊策, 前田勇
    • Organizer
      日本農芸化学会関東支部2007年度大会
    • Place of Presentation
      宇都宮市 宇都宮大学大学会館多目的ホール
    • Year and Date
      2008-11-10
    • Related Report
      2009 Final Research Report
  • [Presentation] acyl-CoA thioesterase II (TesB) family 酵素のβ-酸化中間体に対する基質特異性の解析2008

    • Author(s)
      瀬戸慶彬, 長谷川晴子, 上田俊策, 前田勇
    • Organizer
      第59回日本生物工学会大会
    • Place of Presentation
      東広島市 広島大学東広島キャンパス
    • Year and Date
      2008-09-26
    • Related Report
      2009 Final Research Report
  • [Presentation] acyl-CoA thioesterase II(TesB)family酵素のβ-酸化中間体に対する基質特異性の解析2007

    • Author(s)
      瀬戸 慶彬, 長谷川 清子, 上田 俊策, 前田 勇
    • Organizer
      第59回日本生物工学会大会
    • Place of Presentation
      東広島市、広島大学東広島キャンパス
    • Year and Date
      2007-09-26
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://agri.mine.utsunomiya-u.ac.jp/hpj/deptj/chemj/jmicrobio/microb-eng.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://agri.mine.utsunomiya-u.ac.jp/hpj/deptj/chemj/jmicrobio/microb-eng.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://agri.mine.utsunomiya-u.ac.jp/hpj/deptj/chemj/jmicrobio/microb-eng.html

    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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