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An Overview image of the transcription network regulated by the CCAAT binding complex in Aspergillus oryzae

Research Project

Project/Area Number 19580088
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied microbiology
Research InstitutionNagoya University

Principal Investigator

KATO Masashi  Nagoya University, 大学院・生命農学研究科, 准教授 (70242849)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords微生物 / ゲノム / マイクロアレイ / 発現制御 / 糸状菌 / 転写因子 / Hap複合体 / CCAAT-box / 遺伝子発現 / 麹菌 / CCAAT
Research Abstract

本研究では麹菌Hap複合体により制御される遺伝子群を網羅的に同定し、それら遺伝子群の関連性を明らかにすることを目的とした。その結果、Hap複合体はリボソーマルタンパク質遺伝子などの翻訳関連遺伝子を間接的に抑制することが明らかとなった。また、HapXと協調して鉄に関連した酵素(チトクロームc、アコニターゼなど)や鉄の取り込み系の抑制因子SreAの遺伝子の発現を抑制することが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2009 2008 2007 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (13 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Identification of specific binding sites for XYR1, atranscriptional activator of cellulolytic and xylanolytic genes in Trichoderma reesei2009

    • Author(s)
      Furukawa T, Shida Y, Kitagami N, Mori K, Kato M, Kobayashi T, Okada H, Ogasawara W, Morikawa Y
    • Journal Title

      Fungal Genet Biol (印刷中)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inducer-dependent nuclear localization of a Zn(II)(2)Cys(6)transcriptional activator, AmyR, in Aspergillus nidulans2009

    • Author(s)
      Makita T, Katsuyama Y, Tani S, Suzuki H, Kato N, Todd RB, Hynes MJ, Tsukagoshi N, Kato M, Kobayashi T
    • Journal Title

      Biosci Biotechnol Biochem 73(2)

      Pages: 391-399

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the cis-acting elements involved in regulation of xylanase III gene expression in Trichoderma reesei PC-3-72008

    • Author(s)
      Furukawa T, Shida Y, Kitagami N, Ota Y, Adachi M, Nakagawa S, Shimada R, Kato M, Kobayashi T, Okada H, Ogasawara W, Morikawa Y
    • Journal Title

      Fungal Genet Biol 45(7)

      Pages: 1094-1102

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] analysis of the egl3 upstream region in filamentous fungus Trichoderma reesei2008

    • Author(s)
      Shida Y, Furukawa T, Ogasawara W, Kato M, Kobayashi T, Okada H, Morikawa Y. Functional
    • Journal Title

      Appl Microbiol Biotechnol 78(3)

      Pages: 515-524

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] GFP-tagged expression analysis revealed that some histidine kinases of Aspergillus nidulans show temporally and spatially different expression during the life cycle2008

    • Author(s)
      Suzuki A, Kanamaru K, Azuma N, Kato M, Kobayashi T
    • Journal Title

      Biosci Biotechnol Biochem 72(2)

      Pages: 428-434

    • NAID

      10027524285

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel promoter sequence required for inductive expression of the Aspergillus nidulans endoglucanase gene eglA2008

    • Author(s)
      Endo Y, Yokoyama M, Morimoto M, Shirai K, Chikamatsu G, Kato N, Tsukagoshi N, Kato M, Kobayashi T
    • Journal Title

      Biosci Biotechnol Biochem 72(2)

      Pages: 312-320

    • NAID

      10027523836

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel promoter sequence required for inductive expression of the Aspergillus nidulans endoglucanase gene eglA.2008

    • Author(s)
      Endo, Y., et al.
    • Journal Title

      Bioscience, Biotechnology and Biochemistry 72

      Pages: 312-320

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of the egl3 upstream region in filamentous fungus Trichoderma reesei.2008

    • Author(s)
      Furukawa, T., et al.
    • Journal Title

      Applied Microbioligy and Biotechnology 72

      Pages: 312-320

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the cis-acting elements involved in regulation of xylanase III gene expression in Trichoderma reesei PC-3-7.2008

    • Author(s)
      Furukawa, T., et al.
    • Journal Title

      Fungal Genetics and Biology 45

      Pages: 1094-1102

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro analysis of His-Asp phosphorelays in Aspergillus nidulans: the first direct biochemicalevidence for the existence of His-Asp phosphotransfer systems in filamentous fungi2007

    • Author(s)
      Azuma N, Kanamaru K, Matsushika A, Yamashino T, Mizuno T, Kato M, Kobayashi T
    • Journal Title

      Biosci Biotechnol Biochem 71(10)

      Pages: 2493-2502

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans2007

    • Author(s)
      Hagiwara D, Asano Y, Marui J, Furukawa K, Kanamaru K, Kato M, Abe K, Kobayashi T, Yamashino T, Mizuno T
    • Journal Title

      Biosci Biotechnol Biochem 71(4)

      Pages: 1003-14

    • NAID

      10027513743

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genomics of Aspergillus oryzae2007

    • Author(s)
      Kobayashi T, Abe K, Asai K, Gomi K, Juvvadi PR, Kato M, Kitamoto K, Takeuchi M, Machida M.
    • Journal Title

      Biosci Biotechnol Biochem 71(3)

      Pages: 646-670

    • NAID

      10027512345

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses2007

    • Author(s)
      Hagiwara D, Matsubayashi Y, Marui J, Furukawa K, Yamashino T, Kanamaru K, Kato M, Abe K, Kobayashi T, Mizuno T
    • Journal Title

      Biosci Biotechnol Biochem 71(3)

      Pages: 844-847

    • NAID

      10027513182

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron2007

    • Author(s)
      Hortschansky P, Eisendle M, Al-Abdallah Q, Schmidt AD, Bergmann S, Thon M, Kniemeyer O, Abt B, Seeber B, Werner ER, Kato M, Brakhage AA, Haas H
    • Journal Title

      EMBO J 26(13)

      Pages: 3157-3168

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of HapX with the CCAAT-binding complex-a novel mechanism of gene regulation by iron.2007

    • Author(s)
      Hortschansky P., et. al.
    • Journal Title

      The EMBO Journal 26

      Pages: 3157-3168

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 糸状菌CCAAT結合因子の存在量は栄養状態に応答する2009

    • Author(s)
      伊奈慎太郎、高橋明珠、小林哲夫、加藤雅士
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 糸状菌転写因子HapXによる転写抑制機構2009

    • Author(s)
      安藤栄里子、杉山純也、小林哲夫、加藤雅士
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Interaction of HapX-HapB/C/Ecomplex with the cytochrome c promoter2009

    • Author(s)
      Ando E, Sugiyama J, Hortschansky P, Brakhage AA, Haas H, Kobayashi T, and Kato M
    • Organizer
      25th Fungal Genetics Conference at Asilomar
    • Place of Presentation
      California, USA
    • Year and Date
      2009-03-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Interaction of HapX-HapB/C/E complex with the cytochrome c promoter2009

    • Author(s)
      Ando E., et al.
    • Organizer
      25th Fungal Genetics Conference at Asilomar
    • Place of Presentation
      California, USA
    • Year and Date
      2009-03-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis on the transcriptional regulation network by the CCAAT-binding complex as a key factor in Aspergillus spp. 2008 JSPS and KOSEF Joint Seminar. The Japan-Korea Joint Basic Scientific Cooperation Program2008

    • Author(s)
      Kato, M
    • Organizer
      Pioneering Research on Fungal Molecular Biology
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2008-11-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis on the transcriptional regulation network by the CCAAT-binding complex as a key factor in Aspergillus spp.2008

    • Author(s)
      Kato, M.
    • Organizer
      2008JSPS and KOSEF Joint Seminar. The Japan-Korea Joint Basic Scientific Cooperation Program. Pioneering Research on Fungal Molecular Biology
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression of ribosomal protein genes is depressed by the CCAAT-binding complex in Aspergillus species2008

    • Author(s)
      Takahashi A, Sugiyama J, Sano M, Kobayashi T, and Kato M
    • Organizer
      9th European Conference on Fungal Genetics
    • Place of Presentation
      Edingurgh, Scotland
    • Year and Date
      2008-04-07
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Novel mechanisms of redox and iron regulation of fungal transcription factors2008

    • Author(s)
      Hortschansky P, Eisendle M, Al-Abdallah Q, Schmidt AD, Bergmann S, Thon M, Kniemeyer O, Abt B, Seeber BWerner ER, Kato M, Brakhage AA, Haas H
    • Organizer
      9th European Conference on Fungal Genetics
    • Place of Presentation
      Edingurgh, Scotland
    • Year and Date
      2008-04-07
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 糸状菌CCAAT-box結合因子による転写制御ネットワーク : リボソーマルタンパク質の転写抑制機構2008

    • Author(s)
      高橋明珠、佐野元昭、小林哲夫、加藤雅士
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 糸状菌CCAAT-box結合因子による転写制御ネットワーク:リボソーマルタンパク質の転写抑制2008

    • Author(s)
      高橋 明珠
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 糸状菌CCAAT-box結合因子によるリボソームタンパク質遺伝子の発現抑制機構2007

    • Author(s)
      高橋 明珠
    • Organizer
      第7回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東京
    • Year and Date
      2007-11-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 麹菌CCAAT-box結合因子による転写制御ネットワークの網羅的解析2007

    • Author(s)
      高橋 明珠
    • Organizer
      日本農芸化学会 関西支部・中部支部合同大会
    • Place of Presentation
      愛知県春日井市
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 麹菌CCAAT-box結合因子によるリボソーマルタンパク質遺伝子の発現抑制2007

    • Author(s)
      高橋明珠、杉山純也、佐野元昭、小林哲夫、加藤雅士
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      2007-03-25
    • Related Report
      2008 Final Research Report
  • [Book] In "Aspergillus : Molecular Biology and Genomics".(eds by Machida M and Gomi K)(Transcriptional Regulantion in Aspergillus)2009

    • Author(s)
      Kobayashi T and Kato M
    • Publisher
      Caister Academic Press, Portland, USA
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.agr.nagoya-u.ac.jp/~iden/japanese/index_j.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.agr.nagoya-u.ac.jp/~iden/japanese/indexj.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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