Bioorganic Research on Biologically Active Natural Products towards Development of Agrochemical and Medicinal Lead Compounds
| Project/Area Number |
19580120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KIYOTA Hiromasa Tohoku University, 大学院・農学研究科, 准教授 (30234397)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 抗生物質 / 植物毒素 / 海洋天然物 / ジャスモン酸 / タキサンジテルペノイド / 単離構造決定 / 全合成 / 構造活性相関 / 血管新生阻害 |
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| Research Abstract |
Bioorganic research on biologically active natural products have been achieved. Total synthesis : analogs of polynactin antibiotics, phytotoxin T-beta-L and pyricuols, marine antifeedant pteroenone, plant hormone jasmonic acids, and gizzerosine. Patial synthesis : antibiotics pamamycis, spirofungins and enacyloxins, and anti-angiogenetic cortistatins. Isolation and structure elucidation : enacyloxins, taxanes, limonoids and echinopines.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article]2008
Author(s)
Y. Sato, H. Kamiyama, T. Usui, T. Saito, H. Osada, S. Kuwahara, H. Kiyota
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Journal Title
Biosci.Biotechnol.Biochem. 72巻
Pages: 2292-2297
Related Report
Peer Reviewed
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[Journal Article]2008
Author(s)
A. Miura, S.-y. Takigawa, Y. Furuya, Y. Yokoo, S. Kuwahara, H. Kiyota
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Journal Title
Eur.J.Org.Chem.
Pages: 4955-4962
Related Report
Peer Reviewed
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[Journal Article]2008
Author(s)
M. Dong, B. Cong, S.-H. Yu, F. Sauriol, C.-H. Huo, Q.-W. Shi, Y.-C. Gu, L. O. Zamir, H. Kiyota
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Journal Title
Org.Lett. 10巻
Pages: 701-704
Related Report
Peer Reviewed
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[Journal Article]2007
Author(s)
H. Kiyota, T. Takai, Y. Shimasaki, M. Saitoh, O. Nakayama, T. Takada, S. Kuwahara
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Journal Title
Synthesis
Pages: 2471-2480
Related Report
Peer Reviewed
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