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Elucidation of fish T lymphocyte subgroup based on the CD4 family marker

Research Project

Project/Area Number 19580220
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General fisheries
Research InstitutionFujita Health University

Principal Investigator

J・M Dijkstra  Fujita Health University, 総合医科学研究所, 助教 (10387681)

Co-Investigator(Kenkyū-buntansha) 林 宣宏  藤田保健衛生大学, 総合医科学研究所, 准教授 (80267955)
中西 照幸  日本大学, 生物資源科学部, 教授 (00322496)
橋本 敬一郎  藤田保健衛生大学, 総合医科学研究所, 教授 (70192268)
Co-Investigator(Renkei-kenkyūsha) HAYASHI Nobuhiro  東京工業大学, 大学院・生命理工学研究科・分子生命科学専攻, 准教授 (80267955)
NAKANISHI Teruyuki  日本大学, 生物資源科学部, 教授 (00322496)
HASHIMOTO Keiichiro  藤田保健衛生大学, 総合医科学研究所, 教授 (70192268)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords魚病 / 免疫学的予防 / CD4 / Tリンパ球 / 細胞表面マーカー / 水産学 / 免疫学 / 遺伝子 / ゲノム / 生体分子
Research Abstract

The main project target was to elucidate the CD4 family of molecules in teleost fish, with clonal ginbuna crucian carp as major fish model. This family of molecules is known to form major markers for leukocyte subpopulations, predominantly of T lymphocytes. We found a homologue of mammalian G6F, a marker of platelets, which we designated G6F-like. We could determine that G6F and G6F-like are related to the CD4 family. A monoclonal antibody against G6F-like was established and we found the molecule expressed in ginbuna thrombocytes and erythrocytes.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (9 results)

  • [Journal Article] Zinc-dependent binding between peptides derived from rainbow trout CD8a and LCK.2010

    • Author(s)
      Hayashi N, Takeuchi M, Nakanishi T, Hashimoto K, Dijkstra JM.
    • Journal Title

      Fish Shellfish Immunology 28

      Pages: 72-76

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zinc-dependent binding between peptides derived from rainbow trout CD8alpha and LCK2010

    • Author(s)
      Hayashi N
    • Journal Title

      Fish Shellfish Immunol 28

      Pages: 72-76

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD4 homologues in Atlantic salmon.2009

    • Author(s)
      Moore LJ, Dijkstra JM, Koppang EO, Hordvik I.
    • Journal Title

      Fish Shellfish Immunol. 26

      Pages: 10-18

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD4 homologues in Atlantic salmon2009

    • Author(s)
      Moore LJ
    • Journal Title

      Fish Shellfish Immunol 26

      Pages: 10-18

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD4 homologues in Atlantic salmon2009

    • Author(s)
      Moore, L. J.
    • Journal Title

      Fish Shellfish Immunol. 26

      Pages: 10-18

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish.2008

    • Author(s)
      Ohtani M, Hayashi N, Hashimoto K, Nakanishi T, Dijkstra JM.
    • Journal Title

      Immunogenetics 60

      Pages: 383-397

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive clarification of two paralogous interleukin 4/13 loci in teleostfish2008

    • Author(s)
      Ohtani, M.
    • Journal Title

      Immunogenetics 60

      Pages: 383-397

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2007

    • Author(s)
      Suetake H, Araki K, Akatsu K, Somamoto T, Dijkstra JM, Yoshiura Y, Kikuchi K, Suzuki Y.
    • Journal Title

      Fish Shellfish Immunol. 23

      Pages: 1107-1118

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A third lineage of major histocompatibility complex(MHC)class I inteleost fish; MHC class II-linkage and processed genes.2007

    • Author(s)
      Dijkstra, J. M.
    • Journal Title

      Immunogenetics 59

      Pages: 305-321

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic organization and expression of CD8alpha and CD8beta in fugu Takifugu rubripes.2007

    • Author(s)
      Suetake, H,
    • Journal Title

      Fish Shellfish Immunol. 23

      Pages: 1107-1118

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of additional quantitative trait loci(QTL)responsible for susceptibility to infectious pancreatic necrosis virus in rainbow trout.2007

    • Author(s)
      Ozaki, A.
    • Journal Title

      Fish Pathology 42

      Pages: 131-140

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes.

    • Author(s)
      Ohashi K, Takizawa F, Tokumaru N, Nakayasu C, Toda H, Fischer U, Morimoto T, Hashimoto K, Nakanishi T, Dijkstra JM.
    • Journal Title

      Immunogenetics (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Molecular characteristics of the leukocyte markers CD4-1, CD4-2, LAG-3, CD8alpha and CD8beta in teleost fish.2009

    • Author(s)
      Dijksta JM, Hashimoto K.
    • Organizer
      日本比較免疫学会
    • Place of Presentation
      藤沢
    • Year and Date
      2009-08-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Evolution of genes related to CD4.2009

    • Author(s)
      Dijkstra JM.
    • Organizer
      11 International Congress International Society of Developmental and Comparative Immunology.
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2009 Final Research Report
  • [Presentation] Evolution of genes related to CD42009

    • Author(s)
      Dijkstra JM
    • Organizer
      International Congress International Society of Developmental and Comparative Immunology
    • Place of Presentation
      Prague, Czech
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular characteristics of the leukocyte markers CD4-1, CD4-2, LAG-3, CD8alpha and CD8beta in teleost fish2009

    • Author(s)
      Dijkstra JM
    • Organizer
      日本比較免疫学会
    • Place of Presentation
      藤沢
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evolution of cytokines important for T helper cell differentiation.2008

    • Author(s)
      Dijkstra, J. M.
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Major histocompatibility complex (MHC) linkage groups and disease resistance in salmonid fishes ; a review2008

    • Author(s)
      Dijkstra, J. M.
    • Organizer
      日本比較免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Evolution of cytokines important for T helper cell differentiation.2008

    • Author(s)
      Dijksta JM, Ohtani M, Hayashi N, Nakanishi T, Hashimoto K.
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Unique features of major histocompatibility complex (MHC) genes in fish.2007

    • Author(s)
      Dijksta JM, Hashimoto K.
    • Organizer
      第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Unique features of major histocompatibility complex(MHC)genes in fish.2007

    • Author(s)
      Dijkstra, J. M.
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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