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Functional analysis for sex steroid receptors using over-expressing mutant receptors in teleost

Research Project

Project/Area Number 19580221
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General fisheries
Research InstitutionNagahama Institute of Bio-Science and Technology

Principal Investigator

IKEUCHI Toshitaka  Nagahama Institute of Bio-Science and Technology, バイオサイエンス学部, 講師 (00367898)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords水産学 / 内分泌学 / 環境 / 性ステロイド / 受容体 / 変異体
Research Abstract

8種類の変異体発現ベクター(アンドロゲン受容体2分子種、最終成熟誘起ステロイド受容体2分子種の転写活性化ドメインまたはホルモン結合ドメイン欠失変異体発現コンストラクト)を作製し、メダカ受精卵に導入した。その結果、導入に成功した個体においても正常に配偶子形成が進行しF1世代も得られた。変異体の発現にヒトサイトメガロウィルスプロモーターを使っているために充分な機能を発揮していない可能性が考えられる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (4 results)

All 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] LJ Jr, Guillette, T. Iguchi Molecular Cloning and Characterization of Estrogen, Androgen, and Progesterone Nuclear Receptors from a Freshwater Turtle (Pseudemys nelsoni)2008

    • Author(s)
      Y. Katsu, R. Ichikawa, T. Ikeuchi, S. Kohno
    • Journal Title

      Endocrinology 148

      Pages: 161-173

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Cloning and Characterization of Estrogen, Androgen, and Progesterone Nuclear Receptors from a Freshwater Turtle(Pseudemys nelsoni).2008

    • Author(s)
      Y. Katsu, R.lchikawa, T. lkeuchi, S. Kohno, LJ Jr, Guillette, T. lguchi
    • Journal Title

      Endocrinology 149

      Pages: 161-173

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] アンドロゲン受容体β導入細胞を用いたアンドロゲン活性の評価2008

    • Author(s)
      川崎一馬・池内俊貴
    • Organizer
      平成20年度日本水産学会春期大会
    • Place of Presentation
      東海大学
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] メダカのミネラルコルチコイド受容体2007

    • Author(s)
      池内俊貴
    • Organizer
      日本動物学会第七十八回大会
    • Place of Presentation
      弘前大学
    • Year and Date
      2007-09-22
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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