Analysis of physiological functions of the retinoid X receptor in prosobranch gastropods
Project/Area Number |
19580226
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General fisheries
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Research Institution | National Institute for Environmental Studies |
Principal Investigator |
HORIGUCHI Toshihiro National Institute for Environmental Studies, 環境リスク研究センター, 主席研究員 (30260186)
|
Co-Investigator(Kenkyū-buntansha) |
SHIRAISHI Hiroaki 独立行政法人国立環境研究所, 環境リスク研究センター, センター長 (10124348)
OTA Yasuhiko 国立大学法人鳥取大学, 農学部, 教授 (60069078)
西川 智浩 独立行政法人国立環境研究所, 環境リスク研究センター, 契約職員 (10391137)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 前鰓類 / インポセックス / レチノイドX受容体 / 雄性生殖器 / ペニス / 輸精管 / 分化 / 成長 |
Research Abstract |
前鰓類におけるRXRの機能解析を雄性生殖器の分化・成長との関係に着目して実施した。フィールドでの定期採集によりRXR遺伝子発現と雄性生殖器の発達の季節変化を示し、室内実験によりTBT曝露に伴うペニス形成部位の形態変化とRXR遺伝子発現の経時変化を示した。免疫染色によりRXRが前鰓類に広く分布することを示した。筋肉注射試験の結果、9-cis レチノイン酸の効果にも種差は見られないと考えられた。生殖輸管の分化・形成機序を組織学的に解析した。
|
Report
(3 results)
Research Products
(42 results)
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[Journal Article] Exposure to 9-cis retinoic acid induces penis and vas deferens development in the female rock shell, Thais clavigera2008
Author(s)
Horiguchi, T., Ohta, Y., Nishikawa, T., Shiraishi, F., Shiraishi, H., Morita, M.
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Journal Title
Cell Biol. Toxicol. 24
Pages: 553-562
Related Report
Peer Reviewed
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[Journal Article] A Mu-class glutathione S-transferase (GSTM) from the rock shell Thais clavigera2008
Author(s)
Rhee, J. S., Raisuddin, S., Hwang, D. S., Horiguchi, T., Cho, H. S., Lee, J. S.
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Journal Title
Comp. Biochem. Physiol., Part C 148
Pages: 195-203
Related Report
Peer Reviewed
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[Journal Article] Exposure to 9-cis retinoic acid induces penis and vas deferens development in the female rock shell,Thais clavigera2008
Author(s)
Horiguchi, T., Ohta, Y., Nishikawa, T., Shiraishi, F., Shiraishi, H., Morita, M.
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Journal Title
Cell Biology and Toxicology
Related Report
Peer Reviewed
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[Journal Article] Endocrine disrupting organotin compounds are potent jnducers of hnposex in gastropods and adipogenesis in vertebrates2007
Author(s)
Iguchi, T., Katsu, Y., Horiguchi, T., Watanabe, H., Blumberg, B., Ohta, Y.
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Journal Title
Molecular and Cell Toxicology 3
Pages: 1-10
Related Report
Peer Reviewed
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[Presentation] Annual trend of imposex and organotins content in the Rock shell, Thais clavigera from the coast of Korea2008
Author(s)
Cho, H.S., Park, J.C., Choi, M.K., Choi, H.G., Horiguchi, T.
Organizer
環境ホルモン学会第11回研究発表会, 同講演要旨集, p.164
Place of Presentation
東京
Related Report
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[Presentation] Endocrine disruption caused by organotins in gastropods: from a molecular mechanism to population-level effects2008
Author(s)
Horiguchi, T., Cho, H.S., Imai, T., Hamada, F., Ohta, Y., Iguchi, T., Morishita, F., Matsushima, O., Nagao, T., Nishikawa, J., Shiraishi, F., Shimizu, M., Yamazaki, S., Morita, M., Shiraishi, H.
Organizer
Physical and Chemical Impacts on Marine Organisms -Seeking Sustainability and Postgenomics- pp.13-14
Place of Presentation
Nagoya(Japan)
Related Report
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[Presentation] Induction mechanism of imposex caused by organotin compounds in gastropods: evidence concludes involvement of the retinoid X receptor2008
Author(s)
Horiguchi, T., Shiraishi, H., Ohta, Y., Shiraishi, F., Cho, H.S., Morita, M.
Organizer
5th World Fisheries Congress, Program and Abstracts, p.442
Place of Presentation
Yokohama (Japan)
Related Report
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[Presentation] Imposex and organotin concentrations in Thais orbita and Morula marginalba around Sydney, Australia2008
Author(s)
Horiguchi, T., Colville, A., Hamilton, L., Shiraishi, F., Nakajima, D., Kamata, R., Lim, R., Shiraishi, H.
Organizer
5th SETAC World Congress
Place of Presentation
Sydney (Australia)
Related Report
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[Presentation] Localization of RXR in penis and other tissues of several gastropod species (Muricidae, Buccinidae and Nassariidae) from Japan and Portugal2008
Author(s)
Horiguchi, T., Sousa, A., Ohta, Y., Cho, H.S., Miguez, C., Shiraishi, H.
Organizer
SETAC Europe 18th Annual Meeting, p.150
Place of Presentation
Warsaw (Poland)
Related Report
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[Presentation] Localization of RXR in penis and other tissues of several gastropod species (Muricidae, Buccinidae and Nassariidae) from Japan and Portugal2008
Author(s)
Horiguchi, T., Sousa, A., Ohta, Y., Cho, H. S., Miguez, C., Shirarshi, H.
Organizer
SETAC Europe 18th Annual Meeting
Place of Presentation
Warsaw (Poland)
Related Report
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[Presentation] Induction mechanism of imposex caused by organotin compounds in gastropods : evidence concludes involvement of the retinoid X receptor2008
Author(s)
Horiguchi, T., Shiraishi, H., Ohta, Y., Shiraishi, F., Cho, H. S., Morita, M.
Organizer
5th World Fisheries Congress
Place of Presentation
Yokohama (Japan)
Related Report
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[Presentation] Endocrine disruption caused by organotins in gastropods : from a molecular mechanism to population-level effects2008
Author(s)
Horiguchi, T., Cho, H.S., Imai, T., Hamada, F., Ohta, Y., Iguchi, T., Morishita, F., Matsushima, O., Nagao, T., Nishikaw, J., Shiraishi, F., Shimizu, M., Yamazaki, S., Morita, M., Shiraishi, H.
Organizer
Physical and Chemical Impacts on Marine Organisms -Seeking Sustainability and Postgenomics-
Place of Presentation
Nagoya(Japan)
Related Report
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[Presentation] Annual trend of imposex and organotins content in the Rock shell, Thais clavigera from the coast of Korea2008
Author(s)
Cho, H. S., Park, J. C., Choi, M. K., Choi, H. G., Horiguchi, T.
Organizer
環境ホルモン学会第11回研究発表会
Place of Presentation
東京
Related Report
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[Presentation] Involvement of the retinoid X receptor in the development of imposex caused by organotin compounds in female gastropods2007
Author(s)
Horiguchi, T., Shiraishi, H., Nishikawa, T., Ohta, Y., Shiraishi, F., Cho, H., Nishikawa, J., Morita, M.
Organizer
DIOXIN 2007 International Symposium, p135
Place of Presentation
Tokyo
Related Report
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[Presentation] Long term trends of imposex in the rock shell, Thais clavigera and organotin pollutions in the coast of Korea2007
Author(s)
Cho, H.S., Lee, J.H., Cho, C.R., Choi, H.G., Choi, M.G., Horiguchi, T.
Organizer
SETAC (Society of Environmental Toxicology and Chemistry) Europe 17th Annual Meeting, p.224
Place of Presentation
Porto (Portugal)
Related Report
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[Presentation] Involvement of the retinoid X receptor in the development of imposex caused by organotins in female gastropods2007
Author(s)
Horiguchi, T., Shiraishi, H., Nishikawa, T., Ohta, Y., Shiraishi, F., Cho, H.S., Nishikawa, J., Morita, M.
Organizer
SETAC(Society of Environmental Toxicology and Chemistry) Europe 17th Annual Meeting, p.31
Place of Presentation
Porto (Portugal)
Related Report
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[Presentation] Involvement of the retinoid X receptor in the development of imposex caused by organotin compounds in female gastropods2007
Author(s)
Horiguchi, T., Shiraishi, H., Nishikawa, T., Ohta, Y., Shiraishi, F., Cho, H.S., Nishikawa, J., Morita, M.
Organizer
DIOXIN 20071nternational Symposium
Place of Presentation
Tokyo(Japan)
Related Report
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