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Researches on fish adiponectin and lipid and carbohydrate metabolisms

Research Project

Project/Area Number 19580233
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fisheries chemistry
Research InstitutionTokyo University of Marine Science and Technology

Principal Investigator

USHIO Hideki  Tokyo University of Marine Science and Technology, 海洋科学部, 准教授 (50251682)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脂質 / 糖 / 代謝 / アディポネクチン / 糖尿病 / AMPK
Research Abstract

哺乳類では, 血中アディポネクチンレベルの上昇によって脂肪, 筋および肝細胞における脂質代謝が促進されることが明らかになってきた. また, 哺乳類脂肪細胞の分化や代謝調節において核内受容体PPAR・が重要な働きを担う. 一方, 魚類におけるこれらの存在についてはゼブラフィッシュなどのcDNAおよびESTデータベースによって確認しうるが, 現時点では機能性を有した脂質代謝関連タンパク質が存在するかどうかについては全く情報が得られていない. そこで本研究では, 魚類においても脂質代謝に関与すると考えられるアディポネクチンなどの発現頻度を明らかにし, 脂質代謝調節経路を推定することを目的とした. ニジマスEST配列より, ニジマスアディポネクチンおよび受容体の全配列をin silicoクローニングし, その演繹アミノ酸配列に従って, ニジマスアディポネクチンペプチドを固相合成した. 本ペプチドを用いてウサギ抗血清を作製し, ニジマス肝臓, 血漿等を採取してSDS-PAGEに付し, ウェスタンブロッティングを行った. ウエスタンブロッティングの結果, 認識エピトープの異なる数種類の抗体で交差性が認められるアディポネクチン様成分がニジマス脂肪組織, RTG-2細胞, 血漿に認められることが明らかとなった. 抗ニジマスアディポネクチン抗体が認識するタンパク質は, 哺乳類アディポネクチンに相当する約30k成分以外に高分子成分が認められた. 還元条件下でも同様な傾向を示すことから, ニジマスアディポネクチンはジスルフィド結合以外の相互作用力によって多量体化するものと考えられた.これは, 哺乳類アディポネクチン多量体が還元条件下によって容易に単量体化することと大きく異なった.これらのことから, ニジマスにおけるアディポネクチンの作用メカニズムは哺乳類の多量体アディポネクチンシステムと類似しているものと推定された. ニジマスアディポネクチン受容体には1a, 1bおよび2の3種のアイソフォームが存在するものと推定されたが, 1aは膜貫通回数が少なく, 生理的に機能しないものと推定された.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (91 results)

All 2009 2008 2007

All Journal Article (37 results) (of which Peer Reviewed: 37 results) Presentation (40 results) Book (4 results) Patent(Industrial Property Rights) (10 results) (of which Overseas: 4 results)

  • [Journal Article] The effects of hydroxycinnamic acid derivatives on adiponectin secretion2009

    • Author(s)
      K. Ohara, A. Uchida, R. Nagasaka, H. Ushio, T. Ohshima
    • Journal Title

      Phytomedicine 16

      Pages: 130-137

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidative Activities of Mushroom(Flammulina velutipes)Extract Added to Bigeye Tuna Meat : Dose-Dependent Efficacy and Comparison with Other Biological Antioxidants2009

    • Author(s)
      HND. Bao H. Ushio, T. Ohshima
    • Journal Title

      J.Food Sci. 74

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 養殖飼料への穀類糠成分オリザノールの添加効果2009

    • Author(s)
      風間貴充, 長阪玲子, 潮秀樹, 佐藤秀一
    • Journal Title

      養殖 1

      Pages: 48-50

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of hydroxycinnamic acid derivatives on adiponectin secretion.2009

    • Author(s)
      K. Ohara, A. Uchida, R. Nagasaka, H. Ushio, T. Ohshima.
    • Journal Title

      Phytomedicine 16

      Pages: 130-137

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidative Activities of Mushroom (Flammulina velutipes) Extract Added to Bigeye Tuna Meat : Dose-Dependent Efficacy and Comparison with Other Biological Antioxidants2009

    • Author(s)
      HND. Bao H. Ushio, T. Ohshima.
    • Journal Title

      J. Food Sci. 74

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 養殖飼料への穀類糠成分オリザノールの添加効果.2009

    • Author(s)
      風間貴充, 長阪玲子, 潮 秀樹, 佐藤秀一
    • Journal Title

      養殖 2009. 1

      Pages: 48-50

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Tropomyosins as MajorAllergens in Antarctic Krill and MantisShrimp and Their Amino Acid SequenceCharacteristics. Mar2008

    • Author(s)
      K. Motoyama, Y. Suma, S. Ishizaki, Y. Lu, Y. Nagashima, H. Ushio, K. Shiomi.
    • Journal Title

      Biotechnol. 10

      Pages: 709-718

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidative Activity andAntidiscoloration Efficacy of Ergothioneinein Mushroom(Flammulina velutipes)Extract Added to Beef and Fish Meats2008

    • Author(s)
      HND. Bao, H. Ushio, T. Ohshima
    • Journal Title

      J. Agric Food Chem. 56

      Pages: 10032-10040

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of trans-ferulic acid and gamma-oryzanol on ethanol-induced liver injury in C57BL mouse2008

    • Author(s)
      C. Chotimarkorn, H. Ushio
    • Journal Title

      Phytomedicine 15

      Pages: 951-958

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunomagnetic separation usingcarbonyl iron powder and flow cytometryfor rapid detection of Flavobacteriumpsychrophilum. Anal. Bioanal2008

    • Author(s)
      K. Hibi, H. Ushio, H. Fukuda, K. Mitsubayashi, T. Hayashi, H. Ren, H. Endo
    • Journal Title

      Chem. 391

      Pages: 1147-1152

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of rice germ on plasma adiponectin level in c57BL/6j mice2008

    • Author(s)
      A. Uchida, K. Ohara, R. Nagasaka, H. Ushio, H. Maehara, S. Kanemoto
    • Journal Title

      FEBS J. 275

      Pages: 434-434

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 米抽出物γオリザノールおよびGABAの新たな生理作用2008

    • Author(s)
      潮秀樹, 長阪玲子,…堀正敏
    • Journal Title

      美味技術研究会誌 12

      Pages: 21-25

    • NAID

      130003855325

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the ubiquitous transcription factor Yin Yang 1 by phytosteryl ferulates and their therapeutic potentials2008

    • Author(s)
      R. Nagasaka, K. Ohara, H. Ushio
    • Journal Title

      FEBS J. 275

      Pages: 140-140

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of phytosteryl ferulates on multimeric form of adiponectin secreted from 3T3-L1 adipocytes2008

    • Author(s)
      K. Ohara, R. Nagasaka, H. Ushio
    • Journal Title

      FEBS J. 275

      Pages: 140-140

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of glutathione on mammalian taste cell2008

    • Author(s)
      D. Iwanaga, M. Tanaka, R. Nagasaka, H. Ushio
    • Journal Title

      FEBS J. 275

      Pages: 405-405

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipid oxidized products interact with taste glutamate receptors?2008

    • Author(s)
      A. Shinoda, S. Yamaguchi, R. Nagasaka, H. Ushio, Y. Ninomiya
    • Journal Title

      FEBS J. 275

      Pages: 430-430

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 昆布に含まれるγオリザノール2008

    • Author(s)
      長阪玲子, 篠田明, 潮秀樹, 大島敏明
    • Journal Title

      日水誌 74

      Pages: 61-65

    • NAID

      110006595209

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of phytosteryl ferulates in dextran sulfate sodium-induced colitis in mice. Br2008

    • Author(s)
      Md Islam, Takahisa Murata, M Fujisawa, Reiko Nagasaka, Hideki Ushio, AM Bari, Masatoshi Hori, Hiroshi Ozaki
    • Journal Title

      J. Pharmacol. 154

      Pages: 812-24

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice.2008

    • Author(s)
      Md Isram, . . . H. Ushio, . . . H. Ozaki.
    • Journal Title

      Br. J. Pharmacol. 154

      Pages: 812-824

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Tropomyosins as Major Allergens in Antarctic Krill and Mantis Shrimp and Their Amino Acid Sequence Characteristics2008

    • Author(s)
      K. Motoyama, . . . H. Ushio, . . . K. Shiomi.
    • Journal Title

      Mar. Biotechnol. 10

      Pages: 709-718

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidative Activity and Antidiscoloration Efficacy of Ergothioneine in Mushroom (Flammulina velutipes) Extract Added to Beef and Fish Meats2008

    • Author(s)
      HND. Bao H. Ushio, T. Ohshima.
    • Journal Title

      J. Agric Food Chem. 56

      Pages: 10032-10040

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of trans-ferulic acid and gamma-oryzanol on ethanol-induced liver injury in C57BL mouse.2008

    • Author(s)
      C. Chotimarkorn, H. Ushio
    • Journal Title

      Phytomedicine 15

      Pages: 951-958

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunomagnetic separation using carbonyl iron powder and flow cytometry for rapid detection of Flavobacterium psychrophilum2008

    • Author(s)
      K. Hibi, H. Ushio, . . ., H. Endo
    • Journal Title

      Anal. Bioanal. Chem. 391

      Pages: 1147-1152

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of rice germ on plasma adiponectin level in c57BL/6j mice.2008

    • Author(s)
      A. Uchida, K. Ohara, R. Nagasaka, H. Ushio, H. Maehara, S. Kanemoto
    • Journal Title

      FEBS J. 275, S1

      Pages: 434-434

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 米抽出物γオリザノールおよびGABAの新たな生理作用.2008

    • Author(s)
      潮 秀樹, 長阪玲子, . . . 堀正敏
    • Journal Title

      美味技術研究会誌 12

      Pages: 21-25

    • NAID

      130003855325

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the ubiquitous transcription factor Yin Yang 1 by phytosteryl ferulates and their therapeutic potentials.2008

    • Author(s)
      R. Nagasaka, K. Ohara, H. Ushio
    • Journal Title

      FEBS J. 275, S1

      Pages: 140-140

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of phytosteryl ferulates on multimeric form of adiponectin secreted from 3T3-L1 adipocytes.2008

    • Author(s)
      K. Ohara, R. Nagasaka, H. Ushio
    • Journal Title

      FEBS J. 275, S1

      Pages: 140-140

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of glutathione on mammalian taste cell.2008

    • Author(s)
      D. Iwanaga, M. Tanaka, R. Nagasaka, H. Ushio
    • Journal Title

      FEBS J. 275, S1

      Pages: 405-405

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipid oxidized products interact with taste glutamate receptors?2008

    • Author(s)
      A. Shinoda, S. Yamaguchi, R. Nagasaka, H. Ushio, Y. Ninomiya
    • Journal Title

      FEBS J. 275, S1

      Pages: 430-430

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of trans-ferulic acid and gamma-oryzanol on ethanol induced liver injury in c57BL mouse.2008

    • Author(s)
      C. Chotimarkorn, H. Ushio.
    • Journal Title

      Phytomedicine (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of phytosteryl ferulates in dextran sulfate sodium-induced colitis in mice.2008

    • Author(s)
      H. Ozaki, . H. Ushio
    • Journal Title

      Br. J. Pharmacol., (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of hydroxycinnamic acid derivatives, Biochem. Biophys2007

    • Author(s)
      R. Nagasaka, C. Chotimarkorn, I. M Shafiqul ; M. Hori, H. Ozaki, H. Ushio
    • Journal Title

      Res. Commun. 358

      Pages: 615-619

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of barnacle tropomyosin : divergence from decapod tropomyosins and role as a potential allergen2007

    • Author(s)
      Y. Suma, S. Ishizaki, Y. Nagashima, Y. Lu, H. Ushio, K. Shiomi
    • Journal Title

      Comp. Biochem. Physiol. Part B 147

      Pages: 230-236

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of bleeding treatment and perfusion of yellowtail on lipid oxidation in post mortem muscle2007

    • Author(s)
      J.-H. Sohn, H. Ushio, N. Ishida, M. Yamashita, M. Terayama, T. Ohshima
    • Journal Title

      Food Chem. 104

      Pages: 962-970

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 糠漬け大根におけるγオリザノール含量2007

    • Author(s)
      内田麻子, 大原和幸, 長阪玲子, 潮秀樹
    • Journal Title

      日本調理科学会誌 40

      Pages: 184-188

    • NAID

      110006317857

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid direct determination using combined separation by prepared immunomagnetic and flow cytometry of Flavobacterium psychrophilum2007

    • Author(s)
      K. Hibi, K. Mitsubayashi, H. Fukuda, H. Ushio, T. Hayashi, H. Ren, H. Endo
    • Journal Title

      Biosensors Bioelectronics 22

      Pages: 1916-1919

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of hydroxycinnamic acid derivatives.2007

    • Author(s)
      R. Nagasaka, . H. Ushio
    • Journal Title

      Biochem. Biophys. Res. Commun. 358

      Pages: 615-619

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 養殖魚におけるγオリザノールの蓄積について2009

    • Author(s)
      風間貴充, 長阪玲子, 潮 秀樹, 佐藤秀一, 坂本浩志, 坂本憲一
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 昆布に含まれるガンマオリザノール成分の機能性についての検討2009

    • Author(s)
      長阪玲子, 風間貴充, 潮 秀樹
    • Organizer
      日本水産学会春季大会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 養殖魚におけるγオリザノールの蓄積について2009

    • Author(s)
      風間貴充, 長阪玲子, 潮秀樹, 佐藤秀一, 坂本浩志, 坂本憲一
    • Organizer
      日本水産学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 昆布に含まれるガンマオリザノール成分の機能性についての検討2009

    • Author(s)
      長阪玲子, 風間貴充, 潮秀樹
    • Organizer
      日本水産学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Oral administrations of surfactants perturb mouse plasma adiponectin levels2009

    • Author(s)
      Y. Kiyotani, K. Ohara, R. Nagasaka, H. Ushio
    • Organizer
      日本水産学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Mechanisms for modification of mammalian taste sensation2009

    • Author(s)
      D. Iwanaga, M. Tanaka, S. Yamaguchi, R. Nagasaka, H. Ushio
    • Organizer
      日本水産学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Mechanisms of oxidized oil for modification of mammalian taste perception2009

    • Author(s)
      S. Yamaguchi, A. Shinoda, D. Iwanaga, R. Nagasaka, H. Ushio
    • Organizer
      日本水産学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Inhibition of the ubiquitous transcription factor Nrf2 by phytosteryl ferulates and their therapeutic potentials2009

    • Author(s)
      R. Nagasaka, K. Ohara, H.
    • Organizer
      日本水産学会Ushio
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] The effect of phytosteryl ferulates on mRNA expressions of NF-kappaBs and IkappaBs in 3T3-L1 adipocytes2009

    • Author(s)
      K. Ohara, R. Nagasaka, H. Ushio
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Accumulation of gamma-oryzanol in rainbow trout Oncorhynchus mykiss2009

    • Author(s)
      T. Kazama, R. Nagasaka, H. Ushio, S. Satoh
    • Organizer
      日本水産学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Mechanisms for modification of mammalian taste sensation.2008

    • Author(s)
      D. Iwanaga, M. Tanaka, S. Yamaguchi, R. Nagasaka, H. Ushio
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mechanisms of oxidized oil for modification of mammalian taste perception2008

    • Author(s)
      S. Yamaguchi, A. Shinoda, D. Iwanaga, R. Nagasaka, H. Ushio
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibition of the ubiquitous transcription factor Nrf2 by phytosteryl ferulates and their therapeutic potentials.2008

    • Author(s)
      R. Nagasaka, K. Ohara, H. Ushio
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] The effect of phytosteryl ferulates on mRNA expressioins of NF-kappaBs and IkappaBs in 3T3-L1 adipocytes.2008

    • Author(s)
      K. Ohara, R. Nagasaka, H. Ushio
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Accumulation of gamma-oryzanol in rainbow trout Oncorhynchus mykiss.2008

    • Author(s)
      T. Kazama, R. Nagasaka, H. Ushio, S. Sato
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Oral administration of surfactants perturb mouse plasma adiponectin levels.2008

    • Author(s)
      Y. Kiyotani, K. Ohara, R. Nagasaka, H. Ushio
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular mechanisms involved in lipid accumulation in pufferfish.2008

    • Author(s)
      G. Kaneko, . . ., H. Ushio, S. Watabe
    • Organizer
      5^<th> World Fisheries Congress
    • Place of Presentation
      横浜
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Research for modulation of lipid and carbohydrate metabolisms in teleost through phytosteryl hydroxycinnamates to provide high-quality culture fish.2008

    • Author(s)
      R. Nagasaka, H. Ushio, S. Sato
    • Organizer
      5^<th> World Fisheries Congress
    • Place of Presentation
      横浜
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibition of the ubiquitous transcription factor Yin Yang 1 by phytosteryl ferulates and their therapeutic potentials.2008

    • Author(s)
      R. Nagasaka, K. Ohara, H. Ushio
    • Organizer
      33^<rd> FEBSCongress & 11^<th> IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of rice germ on plasma adiponectin level in c57BL/6j mice.2008

    • Author(s)
      A. Uchida, K. Ohara, R. Nagasaka, H. Ushio, H. Maehara, S. Kanemoto
    • Organizer
      33^<rd> FEBSCongress & 11^<th> IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] The effects of phytosteryl ferulates on multimeric form of adiponectin secreted from 3T3-L1 adipocytes.2008

    • Author(s)
      K. Ohara, R. Nagasaka, H. Ushio
    • Organizer
      33^<rd> FEBSCongress & 11^<th> IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of glutathione on mammalian taste cell.2008

    • Author(s)
      D. Iwanaga, M. Tanaka, R. Nagasaka, H. Ushio
    • Organizer
      33^<rd> FEBSCongress & 11^<th> IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lipid oxidized products interact with taste glutamate receptors?2008

    • Author(s)
      A. Shinoda, S. Yamaguchi, R. Nagasaka, H. Ushio, Y. Ninomiya
    • Organizer
      33^<rd> FEBSCongress & 11^<th> IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Research for modulation of lipid and carbohydrate metabolisms in teleot through phytosteryl hydroxycinnamates to provide high-quality culture fish2008

    • Author(s)
      R. Nagasaka, H. Ushio, S. Satoh
    • Organizer
      5th World Fisheries Congress
    • Place of Presentation
      Yokohama
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular mechanisms involved in lipid accumulation in pufferfish2008

    • Author(s)
      G. Kaneko, T. Yamada, Y. Han, M. Hirayama, R. Nagasaka, H. Ushio, S. Watabe
    • Organizer
      5th World Fisheries Congress
    • Place of Presentation
      Yokohama
    • Related Report
      2008 Final Research Report
  • [Presentation] 魚類におけるガンマオリザノールの蓄積について2008

    • Author(s)
      長阪玲子・Nguen Vu・佐久間萌・内田麻子・潮秀樹・佐藤秀一・坂本浩志・坂本憲一
    • Organizer
      日本水産学会
    • Place of Presentation
      函館
    • Related Report
      2008 Final Research Report
  • [Presentation] 脱脂米糠およびγオリザノール強化脱脂米糠が魚類の代謝に及ぼす影響2008

    • Author(s)
      佐久間萌・長阪玲子・潮秀樹・佐藤秀一
    • Organizer
      日本水産学会
    • Place of Presentation
      函館
    • Related Report
      2008 Final Research Report
  • [Presentation] Inhibition of the ubiquitous transcription factor Yin Yang 1 by phytosteryl ferulates and their therapeutic potentials2008

    • Author(s)
      R. Nagasaka, K. Ohara, H. Ushio
    • Organizer
      33rd FEBS Congress and 11th IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] The effects of phytosteryl ferulates on multimeric form of adiponectin secreted from 3T3-L1 adipocytes2008

    • Author(s)
      K. Ohara, R. Nagasaka, H. Ushio
    • Organizer
      33rd FEBS Congress and 11th IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of glutathione on mammlaian taste cell. D. Iawanaga, M. Tanaka, R. Nagasaka, H. Ushio. Effect of rice germ on plasma adiponectin level in c57Bl mouse2008

    • Author(s)
      A. Uchida, K. Ohara, R.Nagasaka, H. Ushio, H. Maehara, S. Kanemoto.
    • Organizer
      33rd FEBS Congress and 11th IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] Lipid oxidized products interact with taste glutamate receptors?2008

    • Author(s)
      A. Shinoda, D. Iwanaga, S. Yamaguchi, R. Nagasaka, H. Ushio, Y. Ninomiya
    • Organizer
      33rd FEBS Congress and 11th IUBMB Conference
    • Place of Presentation
      Athens, Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] AMPK pathway modulating energy metabolism of teleost2007

    • Author(s)
      R. Nagasaka, N. Vu, H. Ushio
    • Organizer
      日本生化学会・日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] AMPK pathway modulating energy metabolism of teleost2007

    • Author(s)
      R. Nagasaka, Nguen Vu, H. Ushio.
    • Organizer
      BMB2007
    • Place of Presentation
      Kobe
    • Related Report
      2008 Final Research Report
  • [Presentation] The effects of hydroxycinnamic acid derivatives on NF-kB pathway of 3T3-L1 adipocyte2007

    • Author(s)
      K. Ohara, R. Nagasaka, H. Ushio.
    • Organizer
      BMB2007
    • Place of Presentation
      Kobe
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of oxidized oil on mammalian taste perception2007

    • Author(s)
      S. Yamaguchi, H. Shiramasa, I. Tashima, N. Matsuzaki, D. Iwanaga, A. Shinoda, H. Ushio
    • Organizer
      BMB2007
    • Place of Presentation
      Kobe
    • Related Report
      2008 Final Research Report
  • [Presentation] 米抽出物の生活習慣病予防効果2007

    • Author(s)
      内田麻子, 長阪玲子, 潮秀樹, 前原裕之, 金本繁晴
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒドロキシ桂皮酸誘導体が3T3L1 脂肪細胞のアディポサイトカイン分泌に及ぼす影響2007

    • Author(s)
      大原和幸, 長阪玲子, 潮秀樹
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪酸がマウス血中アディポネクチンレベルに及ぼす影響2007

    • Author(s)
      山田和弘, 大原和幸, 長阪玲子, 潮秀樹
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 油脂酸化物が哺乳類の味覚に及ぼす影響2007

    • Author(s)
      山口進, 白砂尋士, 田島郁一, 松崎成秀, 岩永大吾, 潮秀樹
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] ニジマスのガンマオリザノールによる脂質代謝促進作用について2007

    • Author(s)
      長阪玲子・佐久間萌・潮秀樹・佐藤秀一
    • Organizer
      日本水産学会
    • Place of Presentation
      清水
    • Related Report
      2008 Final Research Report
  • [Book] 第21章米糠由来γオリザノールの多彩な生理活性作用.新規素材探索-医薬品リード化合物・食品素材を求めて-.(上村監修)2008

    • Author(s)
      潮秀樹, 堀正敏
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Final Research Report
  • [Book] 第5章糖質, 第7章低分子有機化合物.水圏生化学の基礎.渡部編2008

    • Author(s)
      潮秀樹
    • Publisher
      恒星社厚生閣
    • Related Report
      2008 Final Research Report
  • [Book] 第21章米糠由来γオリザノールの多彩な生理活性作用. 新規素材探索-医薬品リード化合物・食品素材を求めて-. (分担, 上村大輔編)2008

    • Author(s)
      潮 秀樹, 堀 正敏
    • Total Pages
      313
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Annual Research Report
  • [Book] 第5章糖質, 第7章低分子有機化合物. 水圏生化学の基礎. 渡部編.2008

    • Author(s)
      潮 秀樹
    • Publisher
      恒星社厚生閣
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 健康機能成分を吸着・濃縮した乾燥脱脂穀類糠2009

    • Inventor(s)
      潮他7名
    • Industrial Property Rights Holder
      該糠から調製した健康機能成分の濃縮物, 及びそれらの製造方法, 東京海洋大学・(株)サタケ
    • Filing Date
      2009-03-17
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 魚類を用いた植物生理活性物質の濃縮・蓄積方法2009

    • Inventor(s)
      潮, 他5名
    • Industrial Property Rights Holder
      坂本飼料株式会社
    • Filing Date
      2009-03-19
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 健康機能成分を吸着・濃縮した乾燥脱脂穀類糠, 該糠から調製した健康機能成分の濃縮物, 及びそれらの製造方法2009

    • Inventor(s)
      潮, 他7名
    • Industrial Property Rights Holder
      東京海洋大学, (株)サタケ
    • Filing Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 炭酸ガス固定化剤及び該炭酸ガス固定化材を用いた炭酸ガス固定化方法2008

    • Inventor(s)
      潮他4名
    • Industrial Property Rights Holder
      東京海洋大学・(株)サタケ
    • Filing Date
      2008-05-02
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 魚類を用いた植物生理活性物質の濃縮・蓄積方法2008

    • Inventor(s)
      潮他5名
    • Industrial Property Rights Holder
      坂本飼料株式会社
    • Filing Date
      2008-03-19
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 炭酸ガス固定化剤及び該炭酸ガス固定化材を用いた炭酸ガス固定化方法2008

    • Inventor(s)
      潮, 他4名
    • Industrial Property Rights Holder
      東京海洋大学, (株)サタケ
    • Industrial Property Number
      2008-120366
    • Filing Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 魚類を用いた植物生理活性物質の濃縮・蓄積方法2008

    • Inventor(s)
      潮他5名
    • Industrial Property Rights Holder
      坂本飼料株式会社
    • Industrial Property Number
      2008-077700
    • Filing Date
      2008-03-25
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 健康機能成分を吸着・濃縮した乾燥脱脂穀額糠, 該糠から調製した健康機能成分の濃縮物, 及びそれらの製造方法2008

    • Inventor(s)
      潮他7名
    • Industrial Property Rights Holder
      東京海洋大学・(株)サタケ
    • Industrial Property Number
      2008-073390
    • Filing Date
      2008-03-21
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 魚類のタンパク質節約剤及びタンパク質節約方法2007

    • Inventor(s)
      潮他3名
    • Industrial Property Rights Holder
      東京海洋大学
    • Filing Date
      2007-07-06
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 魚類のタンパク質節約剤およびタンパク質節約方法2007

    • Inventor(s)
      潮他3名
    • Industrial Property Rights Holder
      東京海洋大学
    • Industrial Property Number
      2007-178082
    • Filing Date
      2007-07-06
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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