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Elucidation of erythrocyte recognition and invasion by Babesia parasites

Research Project

Project/Area Number 19580334
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

YOKOYAMA Naoaki  Obihiro University of Agriculture and Veterinary Medicine, 原虫病研究センター, 准教授 (80301802)

Co-Investigator(Kenkyū-buntansha) IGARASHI Ikuo  国立大学法人帯広畜産大学, 原虫病研究センター, 教授 (80159582)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords寄生体生物 / 感染症 / 獣医学 / 糖鎖 / 動物 / 衛生 / バベシア原虫 / 赤血球 / 侵入
Research Abstract

Sialic acids and Heparan sulfate located on erythrocytes were demonstrated to play important roles as infectious receptors in the erythrocyte invasion by Babesia parasites. In contrast, several protozoan proteins were also identified as new protozoan ligand candidates. Effects of glycoconjugates or specific antibodies on interfering the specific interactions between the protozoan ligands and erythrocyte receptors would provide us novel knowledge or materials for the development of chemotherapeutic and preventive mesures against babesionsis.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (86 results)

All 2010 2009 2008 2007 Other

All Journal Article (55 results) (of which Peer Reviewed: 54 results) Presentation (29 results) Remarks (2 results)

  • [Journal Article] Evaluation of the in vitro growth-inhibitory effect of epoxomicin on Babesia parasites2010

    • Author(s)
      AbouLaila. M., Nakamura, K., Govind, Y., Yokoyama, N., Igarashi, I.
    • Journal Title

      Vet. Parasitol. 167

      Pages: 19-27

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and evaluation of a nested PCR based on spherical body protein 2 gene for the diagnosis of Babesia bovis2010

    • Author(s)
      AbouLaila. M., Yokoyama, N., Igarashi, I.
    • Journal Title

      Vet. Parasitol. 169

      Pages: 45-50

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of terpene nerolidol on the growth of Babesia parasites2010

    • Author(s)
      AbouLaila, M., Sivakumar, T, Yokoyama, N., Igarashi, I.
    • Journal Title

      Parasitology International 59

      Pages: 278-82

    • NAID

      10029824547

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and pathogenic characterization of an OB1 variant of Babesia rodhaini which has a glycophorin A-independent pathway to murine red blood cells2009

    • Author(s)
      Takabatake, N., Iseki, H., Ikehara, Y., Kanuka, H., Yokoyama, N., Sekimizu, K., Igarashi, I.
    • Journal Title

      Vet. Parasitol. 159

      Pages: 97-104

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Babesia bigemina 200 kDa recombinant antigen in enzyme-linked immunosorbent assay2009

    • Author(s)
      Altangerel, K, Alhassan, A., Iseki, H., Sivakumar, T., Damdinsuren, B., Yokoyama, N., Igarashi, I
    • Journal Title

      Parasitol. Res. 105

      Pages: 249-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and Characterization of Peroxiredoxin in Babesia bovis2009

    • Author(s)
      Tanaka, M., Sakurai, T., Yokoyama, N., Inoue, N., Kawazu, S.
    • Journal Title

      Parasitol. Res. 105

      Pages: 1473-1477

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and immunological characterization of Babesia gibsoni and Babesia microti heat shock protein-702009

    • Author(s)
      Terkawi, M. A., Aboge, G., Jia, H., Goo, Y. K., Ooka, H., Yamagishi, J., Nishikawa, Y., Yokoyama, N., Igarashi, I., Kawazu, S-.I., Fujisaki, K., Xuan, X.
    • Journal Title

      Parasite Immunol. 31

      Pages: 328-340

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of (-)-Epigallocatechin-3-gallate from green tea on the growth of Babesia parasites2009

    • Author(s)
      AbouLaila, M. Yokoyama, N., Igarashi I.
    • Journal Title

      Parasitology 22

      Pages: 1-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression analysis of a Babesia bovis BboP67 gene homologous to the Theileria parva p67 gene2009

    • Author(s)
      Sivakumar, T., Khukhuu, A., Alhassan, A., Aboulaila, M. R. A., Iseki, H., Ota, N., Lijia, Z., Yokoyama, N., Igarashi, I.
    • Journal Title

      J. Protozool. Res. 19

      Pages: 62-71

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of apicidin on in vitro and in vivo growth of Babesia parasites2009

    • Author(s)
      Munkhjargal, T., Aboulaila, M. R. A., Sivakumar, T., Yokoyama, N., Igarashi, I.
    • Journal Title

      J. Protozool. Res. 19

      Pages: 41-49

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of oligomannose-coated liposome-based vaccine on rodent babesiosis2009

    • Author(s)
      Ishigame, T., Takabatake, N., Iseki, H., Ota, N., Koyama, A., Igarashi, I., Nishikawa, Y., Ikehara, Y., Kojima, N., Yokoyama, N.
    • Journal Title

      J. Protozool. Res. 19

      Pages: 10-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Babesia bosis BvP36 gene is expressed at least in the asexual stage of Babesia merozoite2009

    • Author(s)
      Khukhuu, A., Sivakumar, T., Alhassan, A., Ota, N., Yokoyama, N., Igarashi, I.
    • Journal Title

      J. Protozool. Res. 19

      Pages: 34-41

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and pathogenic characterization of an OB1 variant of Babesia rodhaini which has a glycophorin A-independent pathway to murine red blood cells.2009

    • Author(s)
      Takabatake, N., Iseki, H., Ikehara, Y., Kanuka, H., Yokoyama, N., Sekimizu, K., Igarashi, I.
    • Journal Title

      Vet.Parasitol. 159

      Pages: 97-104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Babesia bigemina 200 kDa recombinant antigen in enzyme-linked immunosorbent assay.2009

    • Author(s)
      Altangerel, K, Alhassan, A., Iseki, H., Sivakumar, T., Damdinsuren, B., Yokoyama, N., Igarashi, I
    • Journal Title

      Parasitol.Res. 105

      Pages: 249-254

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and Characterization of Peroxiredoxin in Babesia bovis.2009

    • Author(s)
      Tanaka, M., Sakurai, T., Yokoyama, N., Inoue, N., Kawazu, S.
    • Journal Title

      Parasitol.Res. 105

      Pages: 1473-1477

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and immunological characterization of Babesia gibsoni and Babesia microti heat shock protein-70.2009

    • Author(s)
      Terkawi, M.A., Aboge, G., Jia, H., Goo, Y.K., Ooka, H., Yamagishi, J., Nishikawa, Y., Yokoyama, N., Igarashi, I., Kawazu, S-.I., Fujisaki, K., Xuan, X.
    • Journal Title

      Parasite Immunol. 31

      Pages: 328-340

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of(-)-Epigallocatechin-3-gallate from green tea on the growth of Babesia parasites.2009

    • Author(s)
      AbouLaila, M.Yokoyama, N., Igarashi I.
    • Journal Title

      Parasitology 22

      Pages: 1-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression analysis of a Babesia bovis BboP67 gene homologous to the Theileria parva p67 gene. J.Protozool. Res., 19 : 62-71, 2009.2009

    • Author(s)
      Sivakumar, T., Khukhuu, A., Alhassan, A., Aboulaila, M.R.A., Iseki, H., Ota, N., Lijia, Z., Yokoyama, N., Igarashi, I.
    • Journal Title

      J.Protozool. Res. 19

      Pages: 62-71

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of apicidin on in vitro and in vivo growth of Babesia parasites.2009

    • Author(s)
      Munkhjargal, T., Aboulaila, M.R.A., Sivakumar, T., Yokoyama, N., Igarashi, I.
    • Journal Title

      J.Protozool.Res. 19

      Pages: 41-49

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Oligomannose-Coated Liposome-Based Vaccine on Rodent Babesiosis.2009

    • Author(s)
      Ishigame, T., Takabatake, N., Iseki, H., Ota, N., Koyama, A., Igarashi, I., Nishikawa, Y., Ikehara, Y., Kojima, N., Yokoyama, N.
    • Journal Title

      J.Protozool.Res. 19

      Pages: 10-23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Babesia bosis BvP36 gene is expressed at least in the asexual stage of Babesia merozoite.2009

    • Author(s)
      Khukhuu, A., Sivakumar, T., Alhassan, A., Ota, N., Yokoyama, N., Igarashi, I.
    • Journal Title

      J.Protozool.Res. 19

      Pages: 34-41

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic real-time PCR assay for the quantitative detection of Theileria equi from equine blood samples2008

    • Author(s)
      Kim, C., Blanco, L. B. C., Alhassan, A., Iseki, H., Yokoyama, N., Xuan, X., Igarashi, I.
    • Journal Title

      Vet. Parasitol. 151

      Pages: 158-163

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a rapid immunochromatographic test for simultaneous serodiagnosis of bovine Babesioses caused by Babesia bovis and Babesia bigemina2008

    • Author(s)
      Kim, C., Blanco, L. B. C., Alhassan, A., Iseki, H., Yokoyama, N., Xuan, X., Igarashi, I.
    • Journal Title

      Am. J. Trop. Med. Hyg. 78

      Pages: 117-121

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Babesia : the protective effects of killed Propionibacterium acnes on the infections of two rodent Babesia parasites in mice2008

    • Author(s)
      Iseki, H., Takabatake, N., Ota, N., Ishigame, T., Yokoyama, N., Igarashi, I.
    • Journal Title

      Exp. Parasitol. 118

      Pages: 543-548

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] C3 contributes to the cross-protective immunity induced by Babesia gibsoni phosphoriboprotein P0 against a lethal B. rodhaini infection2008

    • Author(s)
      Terkawi, M. A., Zhang, G., Jia, H., Aboge, G., Goo, Y. K., Nishikawa, Y., Yokoyama, N., Igarashi, I., Kawazu, S. I., Fujisaki, K., Xuan, X.
    • Journal Title

      Parasite Immun. 30

      Pages: 365-370

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro inhibitory effect of fosmidomycin on the asexual growth of Babesia bovis and Babesia bigemina2008

    • Author(s)
      Sivakumar, T., Aboulaila, M. R. A., Khukhuu, A., Iseki, H., Alhassan, A., Yokoyama, N., Igarashi, I.
    • Journal Title

      J. Protozool. Res. 18

      Pages: 71-78

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a rapid immunochromatographic test for simultaneous serodiagnosis of bovine Babesioses caused by Babesia bovis and Babesia bigernina2008

    • Author(s)
      Kim, C., Blanco, L. B. C., Aihassan, A., Iseki, H., Yokoyama, N., Xuan, X., and Igarashi, I.
    • Journal Title

      Am. J. Trop. Med. Hyg 78

      Pages: 117-121

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Babesia : the protective effects of killed Proplonibacteriurn acnes on the infections of two rodent Babesia parasites in mice2008

    • Author(s)
      Iseki, H., Takabatake, N., Ota, N., Ishigame, T., Yokoyama, N., and Izarashi, I.
    • Journal Title

      Exp. Parasitol 118

      Pages: 543-548

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C3 contributes to the cross-protective immunity induced by Babesia gibsoni phosphoriboprotein POagainst a lethal B. rodhaini infection2008

    • Author(s)
      Terkawi, M. A., Zhang, G., jia, H., Aboge, G., Goo, Y. K., Nishikawa, Y., Yokoyama, N., Igarashi, I., Kawazu. S. I. FurisaIci, K. and Xuan, X.
    • Journal Title

      Parasite Immun 30

      Pages: 365-370

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro inhibitory effect of fosmidomycin on the asexual growth of Babesia bovis and Babesia bigemina2008

    • Author(s)
      Sivakumar, T., Aboulaila, M. K. A., Khukhuu, A., Iseki, H., Alhassan, A., Yokoyama, N., and Igarashi, I
    • Journal Title

      J. Protozool. Res 18

      Pages: 71-78

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amount of cholesterol in host membrane affects erythrocyte invasion and replication by Babesia bovis2007

    • Author(s)
      Okubo, K., Yokoyama, N., Takabatake, N., Okamura, M., Igarashi, I.
    • Journal Title

      Parasitology 134

      Pages: 625-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Loop-Mediated Isothermal Amplification (LAMP) method for diagnosis of equine piroplasmosis2007

    • Author(s)
      Alhassan, A., Thekisoe, O. M., Yokoyama, N., Inoue, N., Motloang, M. Y., Mbati, P. A., Yin, H., Katayama, Y., Anzai, T., Sugimoto, C., Igarashi, I.
    • Journal Title

      Vet. Parasitol. 143

      Pages: 155-60

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modification of host erythrocyte membranes by trypsin and chymotrypsin treatments and effects on the in vitro growth of bovine and equine Babesia Parasites2007

    • Author(s)
      Okamura, M., Yokoyama, N., Takabatake, N., Okubo, K., Ikehara, Y., Igarashi, I.
    • Journal Title

      J. Parasitol. 93

      Pages: 208-211

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Babesia bovis : Subcellular localization of host erythrocyte membrane components during their asexual growth2007

    • Author(s)
      Okamura, M., Yokoyama, N., Takabatake, N., Okubo, K., Ikehara, Y., Igarashi, I.
    • Journal Title

      Exp. Parasitol. 116

      Pages: 91-4

    • NAID

      120006390254

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative evaluation of the sensitivity of LAMP, PCR and In vitro culture methods for diagnosis of equine piroplasmosis2007

    • Author(s)
      Alhassan, A., Govind, Y., Tam, N. T., Thekisoe, O. M. M., Yokoyama, N., Igarashi, I.
    • Journal Title

      Parasitol. Res. 100

      Pages: 1165-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro2007

    • Author(s)
      Nakamura, K., Yokoyama, N., Igarashi, I.
    • Journal Title

      Parasitology 134

      Pages: 1347-53

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Cysteine Protease Inhibitors on In Vitro Growth2007

    • Author(s)
      Okubo, K., Yokoyama, N., Govind, Y., Alhassan, A., Igarashi, I.
    • Journal Title

      Exp. Parasitol. 117

      Pages: 214-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Polymerase chain reaction methods for the detection of Theileria equi infection using whole blood compared to pre-extracted DNA samples as PCR templates2007

    • Author(s)
      Alhassan, A., Iseki, H., Kim, C., Yokoyama, N., Igarashi, I.
    • Journal Title

      Trop. Anim.Health Prod. 39

      Pages: 369-74

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of a host erythrocyte sialic acid content in Babesia bovis infection2007

    • Author(s)
      Takabatake, N., Okamura, M., Yokoyama, N., Okubo, K., Ikehara, Y., Igarashi, I.
    • Journal Title

      J. Vet. Med. Sci. 69

      Pages: 999-1004

    • NAID

      110006418717

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of two immunochromatographic tests for the serodiagnosis of bovine babesiosis2007

    • Author(s)
      Kim, C., Alhassan, A., Verdida, R. A., Yokoyama, N., Xuan, X., Fujisaki, K., Kawazu, S, Igarashi, I.
    • Journal Title

      Vet. Parasitol. 148

      Pages: 137-43

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycophorin A-knockout mice, which lost sialoglycoproteins from the red blood cell membrane, are resistant to lethal infection of Babesia rodhaini2007

    • Author(s)
      Takabatake, N., Okamura, M., Yokoyama, N., Ikehara, Y., Akimitsu, N., Arimitsu, N., Hamamoto, H., Sekimizu, K., Suzuki, H., Igarashi, I.
    • Journal Title

      Vet. Parasitol. 148

      Pages: 93-101

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Taqman-based real-time PCR assays for diagnostic detection of Babesia bovis and Babesia bigemina2007

    • Author(s)
      Kim, C., Iseki, H., Maria Shirley Herbas, Yokoyama, N., Suzuki, H., Xuan, X., Fujisaki, K., Igarashi, I.
    • Journal Title

      Am. J. Trop. Med. Hyg. 77

      Pages: 837-41

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A shared antigen among Babesia species : ribosomal phosphoprotein P0 as a universal babesial vaccine candidate2007

    • Author(s)
      Terkawi, M. A., Jia, H., Gabriel, A., Goo, Y. K., Nishikawa, Y., Yokoyama, N., Igarashi, I., Fujisaki, K., Xuan, X.
    • Journal Title

      Parasitol. Res. 102

      Pages: 35-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asexual growth of Babesia Bovis is inhibited by specific sulfated glycoconjugates2007

    • Author(s)
      Bork, S., Yokoyama, N., Hashiba, S., Nakamura, K., Takabatake, N., Okamura, M., Ikehara, Y., Igarashi, I.
    • Journal Title

      J. Parasitol. 93

      Pages: 1501-1504

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Multiplex Loop-Mediated Isothermal Amplification (mLAMP) Method for the Simultaneous Detection of Bovine Babesia Parasites2007

    • Author(s)
      Iseki, H, Alhassan, A, Ohta, N., Thekisoe, O. M. M., Yokoyama, N., Inoue, N., Nambota, A., Yasuda, J., Igarashi, I.
    • Journal Title

      J. Microbiol. Methods 71

      Pages: 281-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary evaluation of oligomannose-coated liposome vaccines against lethal protozoan infections in mice2007

    • Author(s)
      Kuboki, N., Tiwananthagorn, W., Takagi, H., Nakayama, T., Xuan, X., Inoue, N., Igarashi, I., Tsujimura, K., Ikehara, Y., Kojima, N., Yokoyama, N.
    • Journal Title

      J. Protozool. Res. 17

      Pages: 9-15

    • NAID

      130007747168

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amount of cholesterol in host membrane affects erythrocyte invasion and replication by Babesia bo2007

    • Author(s)
      Okubo, K., Yokoyama, N., Takabatake,
    • Journal Title

      Parasitology 134

      Pages: 625-30

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of host erythrocyte membranes by trypsin and chymotrypsin treatments and effects on2007

    • Author(s)
      Okamura, M., Yokoyama, N., Takabatake
    • Journal Title

      J. Parasitol. 93

      Pages: 208-211

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subcellular localization of host erythrocyte membrane components during their asexual growth.2007

    • Author(s)
      Okamura, M., Yokoyama, N., Takabatak
    • Journal Title

      Exp. Parasitol. 116

      Pages: 91-94

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development o2007

    • Author(s)
      Nakamura, K., Yokoyama, N., and Igaras
    • Journal Title

      Parasitology 134

      Pages: 1347-1353

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Babesia bovis: Effects of Cysteine Protease Inhibitors on In Vitro Growth.2007

    • Author(s)
      Okubo, K., Yokoyama, N., Govind, Y., A
    • Journal Title

      Exp. Parasitol. 117

      Pages: 214-217

    • NAID

      120006390267

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of a host ervthrocvte sialic acid content in Babesia bovis infection.2007

    • Author(s)
      Takabatake, N., Okamura, M., Yokoyam
    • Journal Title

      J. Vet. Med. Sci. 69

      Pages: 999-1004

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycophorin A-knockout mice, which lost siaoglycoproteins from the red blood cell membrane, are2007

    • Author(s)
      Takabatake, N., Okamura, M., Yokoyam
    • Journal Title

      Vet. Parasitol. 148

      Pages: 93-101

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asexual growth of Babesia Bovis is inhibited by specific sulfated glycoconjugates.2007

    • Author(s)
      Bork, S., Yokoyama, N., Hashiba, S., Na
    • Journal Title

      J. Parasitol. 93

      Pages: 1501-1504

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seroprevalence of Babesia infections of dairy cows in northern Thailand

    • Author(s)
      Iseki, H., Zhou, L., Kim, C., Inpankaew, T., Sununta, C., Yokoyama, N., Xuan, X., Jittapalapong, S., Igarashi, I.
    • Journal Title

      Vet. Parasitol

    • Related Report
      2009 Final Research Report
  • [Presentation] ウシバベシア2種を同時に診断可能なプロテインアレイの開発2010

    • Author(s)
      玉城志緒, 井関博, 周麗佳, 小山亜紀, 横山直明, Jittapalapong Sathaporn, 五十嵐郁男
    • Organizer
      第149回日本獣医学会学術集会
    • Place of Presentation
      武蔵野
    • Related Report
      2009 Final Research Report
  • [Presentation] Molecular characterization of a new spherical body protein of Babesia bovis and evaluation its potential use for serodiagnosis2009

    • Author(s)
      Terkawi M. Alaa, Seuseu Junior, AbouLaila Mahmound, 横山直明, 玄学南, 五十嵐郁男
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      鳥取
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] バベシア原虫の赤内型増殖に関する分子生物学的研究 (日本獣医学会賞受賞講演)2009

    • Author(s)
      横山直明
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒトバベシア症の簡易迅速血清診断法の開発2009

    • Author(s)
      井関博, Chul-min Kim, 斉藤あつ子, 簑田友香, 猪熊壽, 横山直明, 五十嵐郁男
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] バベシア原虫における遺伝子改変技術の開発2009

    • Author(s)
      田中みほ, 櫻井達也, 井上昇, 横山直明, 玄学南, 河津信一郎
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] バベシア症に対するオリゴマンノース糖鎖被覆リポソームワクチンの効果2009

    • Author(s)
      横山直明, 石亀貴士, 高畠規之, 井関博, 太田奈保美, 小山亜紀, 五十嵐郁男, 西川義文, 池原譲, 小島直也
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] バベシア原虫の赤内型増殖に関する分子生物学的研究(日本獣医学会賞受賞講演)2009

    • Author(s)
      横山直明
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木
    • Related Report
      2009 Annual Research Report
  • [Presentation] タイにおけるウシバベシア症の疫学調査2008

    • Author(s)
      周麗佳, 井関博, Tawin Inpankaew, 横山直明, 玄学南, Sathaporn Jittapalapong, 五十嵐郁男
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      宮崎
    • Related Report
      2009 Final Research Report
  • [Presentation] Growth inhibitory effect of terpene nerolidol against Babesia parasites2008

    • Author(s)
      Abou-Laila, M., Sivakumar, T., Yokoyama, N., Igarashi, I.
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      宮崎
    • Related Report
      2009 Final Research Report
  • [Presentation] バベシア原虫と宿主赤血球膜シアル酸分子の関わりについて2008

    • Author(s)
      横山直明
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスバベシア原虫と宿主赤血球膜シアル酸分子の関わりについて2008

    • Author(s)
      横山直明, 高畠規之, 井関博, 池原譲, 五十嵐郁男
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎
    • Related Report
      2009 Final Research Report
  • [Presentation] Diagnostic real-time PCR assay for the quantitative detection of Theileria equi from equine blood samples2008

    • Author(s)
      横山直明, Chul-min Kim, Lidia Blanco, Andy Alhassan, 井関博, 玄学南, 五十嵐郁男
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      相模原
    • Related Report
      2009 Final Research Report
  • [Presentation] Babesia bovis 2-Cys型ペルオキシレドキシンのクローニングと機能解析2008

    • Author(s)
      田中みほ, 櫻井達也, 横山直明, 井上昇, 川津信一郎
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      相模原
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスバベシア原虫と宿主赤血球膜シアル酸分子の関わりについて2008

    • Author(s)
      横山直明、高畠規之、井関博、池原譲、五十嵐郁男
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎新聞文化ホール(長崎)
    • Related Report
      2008 Annual Research Report
  • [Presentation] バベシア原虫と宿主赤血球膜シアル酸分子の関わりについて2008

    • Author(s)
      横山直明
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県立音楽堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] タイにおけるウシバベシア症の疫学調査2008

    • Author(s)
      周麗佳、井関博、Tawin Inpankaew、横山直明、玄学南、Sathaporn Jittapalapong、五十嵐郁男
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      シーガイア(宮崎県)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Growth inhibitory effect of terpene nerolidol against Babesia parasites2008

    • Author(s)
      Abou-Laila, M., Sivakumar, T., Yokoyama, N., and Igarashi, I
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      シーガイア(宮崎県)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Involvement of host sialic acids in erythrocyte invasion of Babesia parasites2007

    • Author(s)
      Naoaki Yokoyama
    • Organizer
      The 3rd International Zoonosis Seminar
    • Place of Presentation
      Jeju-Do, Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] Epoxomicin inhibits the in vitro growth of Babesia parasites2007

    • Author(s)
      Abou-Laila Mahmoud, 中村一哉, Govind Yadav, 横山直明, 五十嵐郁男
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      江別
    • Related Report
      2009 Final Research Report
  • [Presentation] Glycophorin Aノックアウトマウス内で増殖する Babesia rodhaini の分離2007

    • Author(s)
      高畠規之, 井関博, 池原譲, 関水和久, 横山直明, 五十嵐郁男
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      江別
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of protein kinase inhibitors on the in vitro growth of Babesia bovis2007

    • Author(s)
      Bork-Mimm, S., Das, S., Okubo, K., Yokoyama, N., Igarashi, I., Pfister, K.
    • Organizer
      The 21st International Conference of the World Association for the Advancement of Veterinary Parasitology
    • Place of Presentation
      Belgium
    • Related Report
      2009 Final Research Report
  • [Presentation] バベシア原虫と宿主赤血球膜分子の関わりについて2007

    • Author(s)
      横山直明, 岡村雅史, 高畠規之, 太田奈保美, 池原譲, 五十嵐郁男
    • Organizer
      第15回分子寄生虫学ワークショップ
    • Place of Presentation
      草津
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of Cysteine Protease Inhibitors on the In Vitro Growth of Babesia bovis2007

    • Author(s)
      大久保和洋, 横山直明, 五十嵐郁男
    • Organizer
      第143回日本獣医学会学術集会
    • Place of Presentation
      つくば
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of Cysteine Protease Inhibitors on the In Vitro Growth of Babesia bovis2007

    • Author(s)
      大久保和洋、横山直明、五十嵐郁男
    • Organizer
      第143回日本獣医学会学術集会
    • Place of Presentation
      つくば国際会議場(茨城県
    • Related Report
      2007 Annual Research Report
  • [Presentation] バベシア原虫と宿主赤血球膜分子の関わりについて2007

    • Author(s)
      横山直明、岡村雅史、高畠規之、太田奈
    • Organizer
      第15回分子寄生虫学ワークショップ
    • Place of Presentation
      草津セミナーハウス(群馬、
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of protein kinase inhibitors on the in vitro growth of Babesia bovis2007

    • Author(s)
      Bork-Mimm, S., Das, S., Okubo, K., Yok
    • Organizer
      The 21st International Conference of the World Association for the Advancement
    • Place of Presentation
      ICC-International Conventi
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epoxomicin inhibits the in vitro growth of Babesia parasites2007

    • Author(s)
      Abou-Laila Mahmoud、中村一哉、Govin
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      酪農学園大学(北海道江別
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glycophorin Aノックアウトマウス内で増殖するBabesia rodhainiの分離2007

    • Author(s)
      高畠規之、井関博、池原譲、関水和久、
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      酪農学園大学(北海道江別
    • Related Report
      2007 Annual Research Report
  • [Presentation] Involvement of host sialic acids in erythrocyte invasion of Babesia parasites2007

    • Author(s)
      Naoaki Yokoyama
    • Organizer
      The 3rd International Zoonosis Seminar
    • Place of Presentation
      Seogwipo KAL Hotel(Jeju-
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.obihiro.ac.jp/~protozoa/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.obihiro.ac.jp/~protozoa/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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