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Fundamental researches for pathologic elucidation and antemortem diagnosis in the cerebrospinal degenerative diseases of animals.

Research Project

Project/Area Number 19580371
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

UCHIDA Kazuyuki  The University of Tokyo, 大学院・農学生命科学研究科, 准教授 (10223554)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords小脳変性 / 脊髄変性 / 神経軸索ジストロフィー / 小脳アビオトロフィー / 神経細胞死 / シナプス / イヌ / 小脳皮質アビオトロフィー / セロイド・リポフスチン症 / アポトーシス / ネクローシス / 炎症反応 / 犬 / 小脳脊髄変性症 / 軸索変性 / 小脳萎縮 / Caチャネル
Research Abstract

The research revealed the clinical and pathological features of cerebellar cortical abiotrophy (CCA) in Papillon dogs, neuroaxonal dystrophy (NAD) in Papillon and Chihuahua dogs, and ceroid-lipofuscinosis in Chihuahua dogs. By antemortem image analysis, all these degenerative canine diseases were characterized by moderate to severe cerebellar atrophy. Pathologically, the pathway of neuronal death was differ among these diseases ; apoptosis in CCA, inflammatory reaction associated ceroid-lipofuscin deposits in NCL, and some other injury associated synaptic processes in NAD, are suspected as major role of the pathologic events, respectively.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008 2007 Other

All Journal Article (9 results) (of which Peer Reviewed: 5 results) Presentation (2 results)

  • [Journal Article] Neuronal ceroid-lipofuscinosis in long-haired Chihuahuas : clinical, pathological and magnetic resonance imaging findings2010

    • Author(s)
      Nakamoto Y., Yamato O., Uchida, K., (他7名)
    • Journal Title

      J.Am.Anim.Hosp.Assoc. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical features of dystrophic axons in Papillon Dogs with neuroaxonal dystrophy2009

    • Author(s)
      Nibe K., Uchida K, Nakayama H.
    • Journal Title

      Veterinary Pathology 46

      Pages: 474-483

    • Related Report
      2009 Final Research Report
  • [Journal Article] Immunohistochemical features of dystrophic axons in Papillon Dogs with neuroaxonal dystrophy2009

    • Author(s)
      Nibe K., Uchida K., Nakayama H.
    • Journal Title

      Veterinary Pathology 46

      Pages: 474-483

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical features of dystrophic axons in Papillon Dogs with neuroaxonal dystrophy.2009

    • Author(s)
      K. Nibe, K. Uchida, H. Nakayama
    • Journal Title

      Veterinary Pathology (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological Features of Canine Neuroaxonal Dystrophy and Cerebellar Cortical Abiotrophy in Papillon and Papillon-related Dogs2007

    • Author(s)
      Nibe K. Uchida, K., 他6名, (8番目)
    • Journal Title

      J.Vet.Med.Sci. 69(10)

      Pages: 1047-1052

    • NAID

      130000447587

    • Related Report
      2009 Final Research Report
  • [Journal Article] Magnetic resonance imaging findings of neuroaxonal dystrophy in a Papillon puppy2007

    • Author(s)
      Tamura S, Tamura Y, Uchida K.
    • Journal Title

      Journal of Small Animal Practice 48

      Pages: 458-461

    • Related Report
      2009 Final Research Report
  • [Journal Article] Clinicopathological Features of Canine Neuroaxonal Dystrophy and Cerebellar Cortical Abiotrophy in Papillon and Papillon-related Dogs.2007

    • Author(s)
      K. Nibe, C. Kita, M. Morozumi, , Y. Awamura, S. Tamura, S. Okuno, T. Kobayashi. K. Uchida
    • Journal Title

      J. Vet. Med. Sci. 69(10)

      Pages: 1047-1052

    • NAID

      130000447587

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance imaging findings of neuroaxonal dystrophy in a Papillon puppy.2007

    • Author(s)
      S. Tamura, Y. Tamura K. Uchida
    • Journal Title

      Journal of Small Animal Practice 48

      Pages: 458-461

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal ceroid-lipofuscinosis in long-haired Chihuahuas : clinical, pathological and magnetic resonance imaging findings

    • Author(s)
      Nakamoto Y, Yamato O, Uchida K., 他7名(8番目)
    • Journal Title

      J.Am.Anim.Hosp.Assoc. (In press)

    • Related Report
      2009 Final Research Report
  • [Presentation] イヌの神経軸索ジストロフィー、小脳皮質アビオトロフィーおよび神経セロイド・リポフスチン症における小脳変性に関する病理学的研究2009

    • Author(s)
      二瓶和美, 中山裕之, 内田和幸
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      鳥取大学
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] イヌ神経軸索ジストロフィーの変性軸索におけるシナプス関連タンパクおよびカルシウム結合タンパク蓄積の検討2008

    • Author(s)
      二瓶和美, 内田和幸, 山口良二
    • Organizer
      第145回日本獣医学会
    • Place of Presentation
      麻布大学
    • Related Report
      2009 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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