• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The screening of the new functional compounds for the prevention of cardiovascular events.

Research Project

Project/Area Number 19589002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionYamaguchi University

Principal Investigator

KAJIYA Katsuko  Yamaguchi University, 大学院・医学系研究科, 助教 (00379942)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,090,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords心血管イベント / 機能性食品 / 高脂血症(脂質異常症) / コレステロール / リポソーム / 膜ドメイン / シグナル伝達 / 血管攣縮 / 機能性食品素材 / 高脂血症 / リボソーム
Research Abstract

Abnormal vascular smooth muscle (VSM)contraction (vasospasm) is one of the crucial phenomena which cause cardiac angina and myocardial infarction. We previously found that sphingosylphosphorylcholine (SPC) as an upstream mediator for the abnormal pathway through the activation of Fyn, a member of Src family tyrosine kinase. The localization of Fyn in cholesterol-enriched membrane microdomain, lipid rafts, suggest the essential roles of membrane lipid rafts in abnormal contraction. Therefore, we investigated the relationship between lipid rafts and SPC-induced Ca^<2+>-sensitization of VSM. In addition we screened novel compounds which could inhibit SPC-induced Ca^<2+>-sensitization. Some newly found compounds would be the candidates for novel functional food for vasospasm.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008 2007 Other

All Journal Article (4 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] 血管異常収縮の分子機構と分子標的治療薬の探索2009

    • Author(s)
      川道穂津美、岸博子、加治屋勝子、高田雄一、小林誠
    • Journal Title

      日本薬理学会誌 133

      Pages: 124-129

    • NAID

      10025740121

    • Related Report
      2009 Final Research Report
  • [Journal Article] 血管異常収縮の分子機構と分子標的治療薬の探索2009

    • Author(s)
      川道穂津美, 他
    • Journal Title

      日薬理誌 133

      Pages: 124-129

    • Related Report
      2008 Annual Research Report
  • [Journal Article] スフィンゴ脂質による血管収縮のカルシウム感受性制御の血管病における意義2008

    • Author(s)
      加治屋勝子、岸博子、川道穂津美、小林誠
    • Journal Title

      血管医学 9

      Pages: 223-238

    • Related Report
      2009 Final Research Report
  • [Journal Article] スフィンゴ脂質による血管収縮のカルシウム感受性制御の血管病における意義2008

    • Author(s)
      加治屋勝子
    • Journal Title

      血管医学 9(3)

      Pages: 223-238

    • Related Report
      2008 Annual Research Report
  • [Presentation] 天然物由来の次世代型新規血管病治療薬の開発(3)2010

    • Author(s)
      加治屋勝
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学(東京))
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 天然物由来の次世代型新規血管病治療薬の開発(3)2010

    • Author(s)
      加治屋勝子
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管平滑筋収縮のCa2+-sensitizationにおけるコレステロールと細胞膜ラフトの重要性2009

    • Author(s)
      加治屋勝子
    • Organizer
      筋生理の集い
    • Place of Presentation
      慈恵医科大学(東京)
    • Year and Date
      2009-12-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 血管平滑筋収縮のCa^<2+>-sensitizationにおけるコレステロールと細胞膜ラフトの重要性2009

    • Author(s)
      加治屋勝子
    • Organizer
      筋生理の集い
    • Place of Presentation
      慈恵医科大学(東京)
    • Year and Date
      2009-12-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Function of membrane rafts as a platform of cell signaling on abnorma vascular smooth muscle contraction2009

    • Author(s)
      Katsuko Kajiya
    • Organizer
      36th International Union of Physiological Sciences
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Function of membrane rafts as a platform of cell signaling on abnorma vascular smooth2009

    • Author(s)
      K.Kajiya
    • Organizer
      36th International Union of Physiological Sciences
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Membrane rafts are novel platforms of signal transduction on abnormal vascular smooth muscle contraction2009

    • Author(s)
      Katsuko Kajiya
    • Organizer
      32nd Annual Meeting of Japanese Working Group "Cardiac Structure and Metabolism"
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2009-07-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Membrane rafts are novel platforms of signal transduction on abnormal vascular smooth2009

    • Author(s)
      K.Kajiya
    • Organizer
      32nd Annual Meeting of Japanese Working Group "Cardiac Structure and
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然物由来の次世代型新規血管病治療薬の開発(1)2009

    • Author(s)
      加治屋勝子
    • Organizer
      日本農芸化学会中四国支部第23回講演会
    • Place of Presentation
      高知大学(高知)
    • Year and Date
      2009-01-24
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 天然物由来の次世代型新規血管病治療薬の開発(22009

    • Author(s)
      加治屋勝子
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2009 Final Research Report
  • [Presentation] 天然物由来の次世代型新規血管病治療薬の開発(2)2009

    • Author(s)
      加治屋勝子
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] High affinity of sphingosylphosphorylcholine (SPC) for membrane rafts leading to abnormal vascular contraction2008

    • Author(s)
      Katsuko Kajiya
    • Organizer
      he 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      京王プラザホテル東京(東京)
    • Year and Date
      2008-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] High affinity of sphingosylphosphorylcholine (SPC) for membrane rafts leading to abnormal vascular contraction.2008

    • Author(s)
      Katsuko Kajiya
    • Organizer
      第85回日本生理学会
    • Place of Presentation
      京王プラザホテル東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] (7)加治屋勝子、血管平滑筋の異常収縮におけるコレステロールと細胞膜ラフトの関与2008

    • Author(s)
      加治屋勝子
    • Organizer
      第50回日本平滑筋学会
    • Place of Presentation
      ホテルニューキャッスル(青森)
    • Related Report
      2009 Final Research Report
  • [Presentation] 血管平滑筋の異常収縮におけるコレステロールと細胞膜ラフトの関与2008

    • Author(s)
      加治屋勝子
    • Organizer
      第50回日本平滑筋学会
    • Place of Presentation
      ホテルニューキャッスル(青森)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管平滑筋のスフィンゴシルホスホリルコリン(SPC)誘導異常収縮における膜ラフトの役割2007

    • Author(s)
      加治屋勝子
    • Organizer
      第59回日本生理学会中国四国地方会
    • Place of Presentation
      徳島大学
    • Year and Date
      2007-11-10
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Remarks] ホームページURL

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~lily

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi