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Development and application of sensors selective to biologically active substances

Research Project

Project/Area Number 19590039
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionOkayama University

Principal Investigator

KATSU Takashi  Okayama University, 大学院・医歯薬学総合研究科, 教授 (40112156)

Co-Investigator(Kenkyū-buntansha) KOMAGOE Keiko  岡山大学, 薬学部, 技術専門職員 (50437563)
美馬 伸治  熊本大学, 薬学部, 助教 (50398244)
増田 和文  岡山大学, 大学院・医歯薬学総合研究科, 助教 (00243486)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsイオンセンサー / 酸素電極 / カフェイン / 活性酸素 / ポルフィリン / 膜電位 / 呼吸阻害 / 膜透過 / センサー / スーパーオキシドアニオン / 光不活性化 / 有機アンモニウムイオンセンサー / ヒドロキシルラジカル
Research Abstract

We developed new sensors selective to caffeine and reactive oxygen species such as hydroxyl radical and superoxide anion. We utilized a commercially available oxygen electrode to detect reactive oxygen species. Applications of sensors were performed to determine the precise channel sizes of biologically active substances formed in cellular membranes and to elucidate the mechanism of photo-inactivated action of porphyrins on bacterial membranes.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2010 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (15 results)

  • [Journal Article] A role for HSP70 in protecting against indomethacin-induced gastric lesions2009

    • Author(s)
      Shintaro Suemasu, Ken-ichiro Tanaka, Takushi Namba, Tomoaki Ishihara, Takashi Katsu, Mitsuaki Fujimoto, Hiroaki Adachi, Gen Sobue, Koji Takeuchi, Akira Nakai, Tohru Mizushima
    • Journal Title

      The Journal of Biological Chemistry Vol.284,No.29

      Pages: 19705-19715

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A role for HSP70 in protecting against indomethacin-induced gastric lesions2009

    • Author(s)
      Shintaro Suemasu
    • Journal Title

      The Journal of Biological Chemistry 284

      Pages: 19705-19715

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precise size determination of amphotericin B and nystatin channels formed in erythrocyte and liposomal membranes based on osmotic protection experiments2008

    • Author(s)
      Takashi Katsu, Shiho Okada, Tomonori Imamura, Keiko Komagoe, Kazufumi Masuda, Tsuyoshi Inoue, Satoshi Nakao
    • Journal Title

      Analytical Sciences Vol.24,No.12

      Pages: 1551-1556

    • NAID

      10025208602

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxygen electrode as a new tool to evaluate hydroxyl radical-scavenging ability2008

    • Author(s)
      Keiko Komagoe, Hiroaki Takeuchi, Takashi Katsu
    • Journal Title

      Sensors and Actuators B Vol.134,No.2

      Pages: 516-520

    • NAID

      120002309731

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A caffeine-sensitive membrane electrode: previous misleading report and present approach2008

    • Author(s)
      Takashi Katsu, Yumi Tsunamoto, Nobumitsu Hanioka, Keiko Komagoe, Kazufumi Masuda, Shizuo Narimatsu
    • Journal Title

      Analytica Chimica Acta Vol.620,No.1-2

      Pages: 50-54

    • NAID

      120002309914

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A caffeine-sensitive membrane electrode : previous misleading report and present approach2008

    • Author(s)
      Takashi Katsu
    • Journal Title

      Analytica Chimica Ada 620

      Pages: 50-54

    • NAID

      120002309914

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxygen electrode as a new t001 to evaluate hydroxyl radical-scavenging ability2008

    • Author(s)
      Keiko Komagoe
    • Journal Title

      Sensors and Actuators B 134

      Pages: 516-520

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precise size determination of amphotericin B and nystatin channels formed in erythrocyte and liposomal membranes based on osmotic protection experiments2008

    • Author(s)
      Takashi Katsu
    • Journal Title

      Analytical Sciences 24

      Pages: 1551-1556

    • NAID

      10025208602

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大腸菌外膜の透過性を亢進する物質の探索:アミジノ基を2個有する両親媒性物質2010

    • Author(s)
      駒越圭子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 大腸菌外膜の透過性を亢進する物質の探索 : アミジノ基を2個有する両親媒性物質2010

    • Author(s)
      駒越圭子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] カチオン性ポルフィリンによる細菌の光不活性化機構2009

    • Author(s)
      加藤久登
    • Organizer
      第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      徳島
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] アミジノ基を2コ有する両親媒性物質の大腸菌外膜に対する作用2009

    • Author(s)
      亀井里枝
    • Organizer
      第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      徳島
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 赤血球及びリポソーム膜中に形成されたポリエン抗生物質のチャンネルサイズの定量2009

    • Author(s)
      勝孝
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 酸素電極を用いたスーパーオキシドアニオン消去剤の活性評価2009

    • Author(s)
      駒越圭子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 3価鉄による過酸化水素の分解反応:酸素電極を用いたアプローチ2008

    • Author(s)
      竹内宏明
    • Organizer
      第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-09
    • Related Report
      2009 Final Research Report
  • [Presentation] ポルフィリンによる細菌の光不活性化:抗菌作用と膜電位低下との相関2008

    • Author(s)
      宮本佳奈
    • Organizer
      第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-09
    • Related Report
      2009 Final Research Report
  • [Presentation] ポルフィリンによる細菌の光不活性化 : 抗菌作用と膜電位低下との相関2008

    • Author(s)
      宮本 佳奈
    • Organizer
      第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 3価鉄による過酸化水素の分解反応 : 酸素電極を用いたアプローチ2008

    • Author(s)
      竹内 宏明
    • Organizer
      第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酸素電極を用いたヒドロキシルラジカル消去剤の活性評価2008

    • Author(s)
      駒越圭子
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 浸透圧保護実験を利用したポリエン抗生物質のチャンネルサイズの定量2007

    • Author(s)
      今村友則
    • Organizer
      第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知
    • Year and Date
      2007-11-10
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] ポルフィリンによる細菌の光不活性化:細菌膜への作用機構の解明2007

    • Author(s)
      宮本佳奈
    • Organizer
      第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知
    • Year and Date
      2007-11-10
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 酸素電極を用いたヒドロキシルラジカル定量法の開発と消去剤の活性評価への応用2007

    • Author(s)
      竹内宏明
    • Organizer
      第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知
    • Year and Date
      2007-11-10
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] カフェイン電極:過去の報告に対する再評価と新規電極の開発2007

    • Author(s)
      綱本優美
    • Organizer
      第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知
    • Year and Date
      2007-11-10
    • Related Report
      2009 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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