• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Basic research for finding the mechanism of paradox appeared in Controlling asthma

Research Project

Project/Area Number 19590055
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

SAITO Shin-ya  University of Shizuoka, 薬学部, 准教授 (80271849)

Co-Investigator(Kenkyū-buntansha) NAKAHATA Norimichi  東北大学, 大学院・薬学研究科, 教授 (60045804)
YAMAKUNI Tohru  東北大学, 大学院・薬学研究科, 准教授 (30333793)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords薬理学 / 細胞内情報伝達 / 天然生理活性物質 / 喘息 / 平滑筋 / ホスホジエステラーゼ / 平滑筋収縮 / プロスタノイド / VDCC / カチオンチャネル / アラキドン酸 / cAMP / ホスホエステラーゼ / C1チャネル / PKA
Research Abstract

我々は膜透過性cAMP誘導体およびPDE1阻害薬を使った実験から、cAMPは気管拡張反応を担う重要なセカンドメッセンジャーであるにも関わらず、収縮にも寄与しうることを明らかにした。このことは実は喘息治療薬のパラドックスとして知られている問題の根本には矛盾がないことを示している。今後はどのような条件/細胞内環境がcAMP 機能の切り替えを担っているのかを明らかにすることで、治療薬のより安全な使用方法が確立され得るものと期待される。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Shishihakuhito, a traditional Chinese medicine for atopic dermatitis, inhibits IgE-mediated histamine release from rat RBL-2H3 basophilic leukocyte cells2009

    • Author(s)
      Wakabayashi M., Sakurai E., Yanai K., Umemura K., Yoshida M., Ohizumi Y., Yamakuni T.
    • Journal Title

      J. Trad. Med 26

      Pages: 44-49

    • NAID

      110007137398

    • Related Report
      2008 Final Research Report
  • [Journal Article] Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus2008

    • Author(s)
      Matsuzaki K., Miyazaki K., Sakai S., Yawo H., Nakata N., Moriguchi S., Fukunaga K., Yokosuka A., Sashida Y., Mimaki Y., Yamakuni T., Ohizumi Y.
    • Journal Title

      Eur J Pharmacol 578

      Pages: 194-200

    • Related Report
      2008 Final Research Report
  • [Journal Article] βγ subunits of Gi/o suppress epidermal growth factor-induced phosphorylation of extracellular signal-regulated kinase 5, whereas they enhance phosphorylation of extracellular-signal regulated kinase 1/22008

    • Author(s)
      Obara Y., Okano Y., Ono S., Yamauchi A., Hoshino T., Kurose H., Nakahata N.
    • Journal Title

      Cell. Signal 20

      Pages: 1275-1283

    • Related Report
      2008 Final Research Report
  • [Journal Article] Nobiletin, a citrus flavonoid, reverses learning impairment associated with NMDA receptor antagonism by activation of ERK signaling2007

    • Author(s)
      Nakajima A., Yamakuni T., Matsuzaki K., Nakata N., Onozuka H., Yokosuka A., Sashida Y., Yoshihiro Mimaki Y., Ohizumi Y.
    • Journal Title

      J. Pharmacol. Exp. Ther 321

      Pages: 784-790

    • Related Report
      2008 Final Research Report
  • [Journal Article] Distinct effects of Z-335, a new thromboxane A_2 receptor antagonist, on rabbit platelets and aortic smooth muscles2007

    • Author(s)
      Yoshida M., Sato Y., Shimura T., Ohkubo S., Honma S., Tanaka T., Kurimoto T., Nakahata N.
    • Journal Title

      Pharmacology 79

      Pages: 50-56

    • Related Report
      2008 Final Research Report
  • [Journal Article] Low expression of cell-surface thromboxane A_2 receptor b-isoform through the negative regulation of its membrane traffic by proteasomes2007

    • Author(s)
      Sasaki M., Sukegawa J., Miyosawa K., Yanagisawa T., Ohkubo S., Nakahata N.
    • Journal Title

      Prostagland. Other Lipid Mediat 83

      Pages: 237-249

    • Related Report
      2008 Final Research Report
  • [Journal Article] Piperlongmine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A2 recepter antagonist2007

    • Author(s)
      Iwashita M., Oka N., Ohkubo S., Saito M., Nakahata N.
    • Journal Title

      Eur. J. Pharmacol 570

      Pages: 38-42

    • Related Report
      2008 Final Research Report
  • [Journal Article] Mastoparan inhibits β-adrenoceptor-Gs signaling by changing the localization of Gas in lipid rafts2007

    • Author(s)
      Sugama J., Yu J.-Z., Rasenick M.M., Nakahata N.
    • Journal Title

      Cell. Signal 19

      Pages: 2247-2254

    • Related Report
      2008 Final Research Report
  • [Journal Article] Alteration of adenylyl cyclase type 6 expression in human astrocytoma cells after exposure to simulated microgravity2007

    • Author(s)
      Matsuoka R., Ohkubo S., Yoshida M. Nakahata N.
    • Journal Title

      J. Health Sci 53

      Pages: 534-542

    • NAID

      110006402639

    • Related Report
      2008 Final Research Report
  • [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins2007

    • Author(s)
      Ikeda A, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 363

      Pages: 835-839

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Contribution of phospholipase A_2 to U46619-induced vascular contraction in rat aorta2009

    • Author(s)
      Suzuki K., Nishijima A., Saito S., Ishikawa T.
    • Organizer
      第82回日本薬理学会年会(J. Pharmacol. Sci.)
    • Place of Presentation
      横浜(109(Supl. 1))
    • Year and Date
      2009-03-17
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット大動脈U46619誘発性血管収縮反応におけるホスホリパーゼA_2の関与2009

    • Author(s)
      鈴木公章
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of phospholipase A_2 product in U46619-induced contraction mediated by voltage dependent Ca^<2+> channel in the presence of indomethacin2008

    • Author(s)
      Nishijima A., Saito S., Ishikawa T.
    • Organizer
      第81回日本薬理学会年会(J. Pharmacol. Sci.)
    • Place of Presentation
      横浜(106(Supl. 1))
    • Year and Date
      2008-03-17
    • Related Report
      2008 Final Research Report
  • [Presentation] インドメタシン存在下で電位依存性Caチャネルを介するU46619誘発性収縮におけるホスホリパーゼA_2産生物の役割2008

    • Author(s)
      西島愛美
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Related Report
      2007 Annual Research Report
  • [Book] Toxins affecting actin filaments and microtubules. In Marine Toxins as Research Tools. (Fusetani N. and Kem W. eds.)2009

    • Author(s)
      Saito S
    • Publisher
      Springer-Verlag
    • Related Report
      2008 Final Research Report
  • [Book] Marine Toxins as Research Tools(Nobuhiro Fusetani and William Kem eds. )2009

    • Author(s)
      Shin-ya Saito
    • Publisher
      Springer-Verlag
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi