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Molecular mechanism of the progression of Atherosclerosis triggered by degradation of form cells

Research Project

Project/Area Number 19590079
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionTeikyo University

Principal Investigator

YAMAGUCHI Shinj (2008)  Teikyo University, 薬学部, 助教 (60398740)

高野 達哉 (2007)  Teikyo University, 薬学部, 教授 (40124995)

Co-Investigator(Kenkyū-buntansha) 本間 光一  帝京大学, 薬学部, 准教授 (90251438)
山口 真二  帝京大学, 薬学部, 助教 (60398740)
Co-Investigator(Renkei-kenkyūsha) HONMA Koichi  帝京大学, 薬学部, 薬学部 (90251438)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords粥状動脈硬化 / マクロファージ / 泡沫細胞 / 酸化リホタンバク質 / アホトーシス / 酸化リポタンパク質 / ニワトリ / アポトーシス
Research Abstract

高脂血漿が引きがねとなる動脈硬化が進行する過程において、マクロファージは動脈壁に流入してくる過剰のリポタンパク質ならびに変性リポタンパク質を細胞内に取り込み泡沫化する。肥大化した泡沫細胞は動脈壁内で崩壊し、変性リポタンパク質が細胞間に放出されるにともない、粥腫が形成される、ヒト高脂血症患者血清から、泡沫細胞誘導・崩壊泡沫細胞の崩壊をひきおこす因子の同定を試みている。また、泡沫細胞崩壊機構のメカニズムがアポトーシスによることを示した。これらの成果を、原著論文Arterioscler Thromb Vasc Biol.29, 33-39(2009)、J Lipid Res.48, 1280-1292(2007)で報告した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (14 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice2009

    • Author(s)
      Kato, R.,Mori, C.,Kitazato, K.,Arata, S.,Obama, T.,Mori, M.,Takahashi, K.,Aiuchi, T.,Takano, T.,Itabe H.
    • Journal Title

      Arterioseler Thromb Vase Bid 29

      Pages: 33-39

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor2008

    • Author(s)
      Iijirna, R., Kunieda, T., Yamaguchi, S., Kamigaki, H., Fujii-Taira, I., Sekimizu, K., Kubo, T., Natori, S. and Homma. K.J.
    • Journal Title

      J.Biol.Cltem. 283

      Pages: 2255-2264

    • Related Report
      2008 Final Research Report
  • [Journal Article] Gene expression profile in cerebrum in the filial ial imprinting of domestic chick (Gallus gallus donlesticus)2008

    • Author(s)
      Yamaguchi, S., Fujii-Taira, I., Katagiri, S., Izawa, E., Fujimoto, Y, Takeuchi, H., Takano, T., Matsushima, T. and Homma, K.J.
    • Journal Title

      Brain Res. Bull 76

      Pages: 275-281

    • Related Report
      2008 Final Research Report
  • [Journal Article] Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chick (Gallus galltts domesticus)2008

    • Author(s)
      Yamaguchi, S., Fujii-Taira, I., Murakami, A., Hirose, N., Aoki, N., Izawa, E., Fujimoto, Y., Takano, T., Matsushima, T., and Homma, K.J.
    • Journal Title

      Brain Res. Bull 76

      Pages: 282-288

    • Related Report
      2008 Final Research Report
  • [Journal Article] The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor2008

    • Author(s)
      Iijima, R., et al.
    • Journal Title

      J. Biol. Cbem. 283

      Pages: 2255-2264

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profile in cerebrum in the filial imprinting of domestic chich(Gallus gallus domesticus)2008

    • Author(s)
      Yamaguchi, S, et al.
    • Journal Title

      Brain Res. Bull. 76

      Pages: 275-281

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chick(Gallus gallus domestious)2008

    • Author(s)
      Yamaguchi, S., et al.
    • Journal Title

      Brain Res. Bull. 76

      Pages: 282-288

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In viva gene transfer into newly-hatched chick brain by electroporation2007

    • Author(s)
      Yamaguchi, S., Katagiri, S., Hirose, N., Fujimoto, Y., Mori, M., Fujii-Taira, I., Takano, T., Matsushima, T. and Homma, K. J.
    • Journal Title

      Neuroreport 18

      Pages: 735-739

    • Related Report
      2008 Final Research Report
  • [Journal Article] Truncated TrkB-T1 regulates the morphology of neocortical layer I astrocytes in adult rat brain slices2007

    • Author(s)
      Ohira, K., Funatsu, N., Homma, K. J., Sahara, Y., Hayashi, M., Kaneko, T. and Nakamura, S.
    • Journal Title

      Eur. J. Neurosci 25

      Pages: 406-416

    • Related Report
      2008 Final Research Report
  • [Journal Article] Involvement of long chain acyl-CoA synthetase in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH72007

    • Author(s)
      Fujimoto, Y., Itabe, H., Kinoshita, T., Homma, K. J., Onoduka, J., Mori, M., Yamaguchi, S., Makita, M., Higashi, Y., Yamashita, A. and Takano, T.
    • Journal Title

      J Lipid Res. 48

      Pages: 1280-1292

    • Related Report
      2008 Final Research Report
  • [Journal Article] In vivo gene transfer into newly-hatched chick brain by electroporation2007

    • Author(s)
      Yamaguchi, S., et. al.
    • Journal Title

      Neuroreport 18

      Pages: 735-739

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of long chain acyl-CoA synthetase in lccal synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7.2007

    • Author(s)
      Fujllnoto, Y., et. al.
    • Journal Title

      J Lipid Res. 48

      Pages: 1280-1292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大脳領野への神経細胞選択的遺伝子導入法を利用した鳥類刻印付けの分子機構の解明2008

    • Author(s)
      本間光一
    • Organizer
      大脳領野への神経細胞選択的遺伝子導入法を利用した鳥類刻印付けの分子機構の解明
    • Place of Presentation
      一ツ橋学術総合センター
    • Year and Date
      2008-12-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 鳥類刻印付けの分子基盤の解明2008

    • Author(s)
      片桐幸子、山口真二、平郁子、本間光一
    • Organizer
      日本薬学会生物系薬学部会「プアーマ・バイオフォーラム2008」
    • Place of Presentation
      日本薬学会長井記念ホール
    • Year and Date
      2008-11-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 鳥類刻印付けの分子基盤の解明2008

    • Author(s)
      片桐 幸子
    • Organizer
      ファーマバイオフォーラム2008
    • Place of Presentation
      東京・渋谷
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大脳領野への神経細胞選択的遺伝子導入法を利用した鳥類刻印付けの分子機構の解明2008

    • Author(s)
      本間光一
    • Organizer
      特定領域研究「統合脳」夏のワークショップ合同班会議、統合シンポジウム、サテライトシンポジウム
    • Place of Presentation
      北海道厚生年金会館(ウェルシティ札幌)
    • Year and Date
      2008-08-07
    • Related Report
      2008 Final Research Report
  • [Presentation] RNAiによるニワトリヒナ大脳での特異的遺伝子抑圧系の確立2008

    • Author(s)
      片桐幸子、広瀬直樹、山口真二、平郁子、藤本康之、高野達哉、松島俊也、本間光一
    • Organizer
      日本薬学会128回大会
    • Related Report
      2008 Final Research Report
  • [Presentation] 鳥類のVSP2008

    • Author(s)
      本間光一、山口真二
    • Place of Presentation
      自然科学研究機構生理学研究所
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪滴アシルCoA合成酵素2007

    • Author(s)
      藤本 康之
    • Organizer
      BMB2007 第80回日本生化学会大会、第30回日本分子生物学会年会、合同大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gene expression profiling associated with the filial imprinting of domestic chicks2007

    • Author(s)
      Homma. K.J., Yamaguchi, S.
    • Organizer
      IBRO satellite on 'Brain Mechanisms, Cognition and Behaviour in Birds.'
    • Place of Presentation
      Heron Island, Queensland, Australia
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] In vivo gene transfer into neuronal cells of newly-hatched chick brain2007

    • Author(s)
      Yamaguchi, S., Homma, K.J.
    • Organizer
      IBRO satellite on 'Brain Mechanisms, Cognition and Behaviour in Birds.'
    • Place of Presentation
      Heron Island, Queensland, Australia
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] In vivoエレクトロボレーション法による鳥類生後脳における神経細胞選択的遺伝子導入2007

    • Author(s)
      片桐幸子、廣瀬直樹、山口真二、藤本康之、松島俊也、高野達哉、本間光一
    • Organizer
      遺伝子・デリバリー研究会第7回シンポジウム
    • Related Report
      2008 Final Research Report
  • [Presentation] 鳥類の大脳神経細胞選択的なin vivo遺伝子導入法の確立2007

    • Author(s)
      廣瀬直樹、片桐幸子、山口真二、藤本康之、松島俊也、高野達哉、本間光一
    • Organizer
      日本神経科学会30回大会
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞外アデノシンデアミナーゼのアフリカツメガエル胚発生での機能解析2007

    • Author(s)
      山口真二、國枝武和、飯島亮子、神垣ひろこ、平郁子、久保武雄、名取俊二、本間光一
    • Organizer
      日本生化学会80回大会
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪滴アシルCoA合成酵素2007

    • Author(s)
      藤本康之、板部洋之、木下哲昭、本間光一、山口真二、小野塚潤、山下純、前田正知、高野達哉
    • Organizer
      日本生化学会80回大会
    • Related Report
      2008 Final Research Report
  • [Presentation] ショウジョウバ工細胞膜型ステロイド結合蛋白によるエクダイソン情報伝達の調節2007

    • Author(s)
      平郁子、山口真二、飯島亮子、名取俊二、本間光一
    • Organizer
      日本生化学会80回大会
    • Related Report
      2008 Final Research Report
  • [Book] New Frontier in Lifestyle-Related Diseases. Regulation of Intracellular Lipid Storage and Adipose Differentiation-Related Protein (ADRP)2008

    • Author(s)
      Itabe,H., Masuda, Y, Sasabe, N., Kitazato, K., Arai, H., Takano, T.
    • Publisher
      Springer
    • Related Report
      2008 Final Research Report
  • [Book] New Frontiers in Lifestyle-Related Diseases.2008

    • Author(s)
      Miyazaki, A, et. al.
    • Total Pages
      308
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.teikyo-u.ac.jp/lab/byotai/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.teikyo-u.ac.jp/lab/byotai/index.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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