• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of regulation mechanism of expression and activity of target molecule (C/EBPα) for therapy of leukemia.

Research Project

Project/Area Number 19590082
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionTokyo University of Science

Principal Investigator

SHIMIZU Takahisa  Tokyo University of Science, 総合研究機構, 講師 (30287479)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords発現制御 / 白血病 / レチノイン酸 / GM-CSF
Research Abstract

白血病治療のための重要な標的因子であるC/EBPαの発現及び活性制御機構に関する研究を行った結果、C/EBPαはその発現及び修飾(SUMO化)制御や、STAT5との複合体形成を介して、標的遺伝子であるId1遺伝子の発現を誘導している可能性が示唆された。この作用は白血病細胞を分化誘導し、がん化形質抑制に関与しているので、これら因子の同定は白血病治療において有益な情報となることが期待できる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Synergistic induction of gene expression during the differentiation into mature macrophage in human myeloblastic leukemia cells treated with TPA and KH1060.2009

    • Author(s)
      Shimizu T, Kuromi A, Takeda K.
    • Journal Title

      Leuk Res. 33

      Pages: 803-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic induction of gene expression during the differentiation into mature macrophage in human myeloblastic leukemia cells treated with TPA and KH1060.2009

    • Author(s)
      Takahisa Shitnizu, et al.
    • Journal Title

      Leukemia Research 33

      Pages: 803-809

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of nanoparticles on mouse testis Leydig cells in vitro.2009

    • Author(s)
      Tomoko Komatus, et al.
    • Journal Title

      Toxicology in Vitro 22

      Pages: 1825-1831

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of nanoparticles on mouse testis Leydig cells in vitro.2008

    • Author(s)
      Komatsu T, Tabata M, Kubo-Irie M, Shimizu T, Suzuki K, Nihei Y, Takeda K.
    • Journal Title

      Toxicol In Vitro. 22

      Pages: 1825-31

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Analysis of gene expression during KH1060 plus TPA-induced differentiation of human myeloblastic leukemia cells.2008

    • Author(s)
      清水 貴壽、武田 健
    • Organizer
      第67回 日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of gene expression during KH1060 plus TPA-induced differentiation of human myeloblastic leukemia cells.2008

    • Author(s)
      清水 貴壽
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Involvement of the helix-loop-helix protein ID-1 in granulocytic differentiation of human myeloblastic leukemia cells.2008

    • Author(s)
      Takahisa Shimizu, Ken Takeda.
    • Organizer
      20^<th> EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      ジュネーブ(スイス)
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] The expression analysis of histone-modifing enzymes during the differentiation of human myeloblastic leukemia cells.2007

    • Author(s)
      清水 貴壽、武田 健
    • Organizer
      第66回 日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] The expression analysis of histone-modifing enzymes during the differentiation of human myeloblastic leukemia cells.2007

    • Author(s)
      清水 貴壽
    • Organizer
      第 66 回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi