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Design and Synthesis of Furan-fused Polycyclic Compounds for Development of New Anti-influenza Agents

Research Project

Project/Area Number 19590099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionUniversity of Toyama

Principal Investigator

NEMOTO Hideo  University of Toyama, 大学院・医学薬学研究部 (薬学), 教授 (60006351)

Co-Investigator(Kenkyū-buntansha) MATSUYA Yuji  富山大学, 大学院・医学薬学研究部 (薬学), 助教 (50255858)
落合 宏  富山大学, 大学院・医学薬学研究部(医学), 教授 (30018692)
Co-Investigator(Renkei-kenkyūsha) OCHIAI Hiroshi  富山大学, 大学院・医学薬学研究部 (薬学), 教授 (30018692)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsインフルエンザ / 抗ウイルス作用 / 構造活性相関 / 合成化学 / ウイルス / 生理活性 / 有機化学
Research Abstract

新しいインフルエンザ治療薬の開発を目指し、従来にない化学構造を有するフラン融合4環系化合物の構造活性相関を検討した。その結果、顕著なインフルエンザウイルス増殖抑制作用を示す新規誘導体を見出した。本薬剤は、現在汎用されているノイラミニダーゼ阻害剤(タミフルなど)とは作用機序が異なることが判り、新規な抗インフルエンザ薬の有望なシーズとなることが期待される。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Studies toward Intramolecular Cycloaddition of o-Quinodimethane with an Oxazole Moiety2009

    • Author(s)
      Matsuya, Y, Qin, H, Nemoto, H
    • Journal Title

      Heterocycles 79(Prepress)

    • NAID

      40016543106

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Studies toward Intramolecular Cycloaddition of o-Quinodimethane with an Oxazole Moiety.2009

    • Author(s)
      Matsuya, Y., Qin, H., Nemoto, H.
    • Journal Title

      Heterocycles 79(掲載確定)

    • NAID

      40016543106

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Approach to a New Dihydrofuran-Fused Cyclic System by a Remarkable Switching of endo/exo Selectivity of a [4+2] Cycloaddition Reaction2008

    • Author(s)
      Matsuya, Y, Imamura, Y, Miyahara, T, Ochiai, H., Nemoto, H.
    • Journal Title

      Eur. J. Org. Chem

      Pages: 1426-1430

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Approach to a New Dihydrofuran-Fused Cyclic System by a Remarkable Switching of endo/exo Selectivity of a [4+2] Cycloaddition Reaction2008

    • Author(s)
      Matsuya, Y.; Imamura, Y.; Miyahara, T.; Ochiai, H.; Nemoto, H.
    • Journal Title

      European Journal of Organic Chemistry

      Pages: 1426-1430

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chemistry and Biology of Benzocyclobutenes : Facile o-Quinodimethane Formation and Transformation to New Bioactive Compounds2008

    • Author(s)
      Matsuya Y, Sasaki K., Ohsawa N, , Yu D.-Y, Zhao Q.-L, Ahmed K., Wei Z.-L., Kondo T, and Nemoto H.
    • Organizer
      XXth International Symposium on Medicinal Chemistry
    • Place of Presentation
      Vienna
    • Related Report
      2008 Final Research Report
  • [Presentation] "Benzocyclobutene" Synthetic Organic Chemistry and Medicinal Chemistry.2008

    • Author(s)
      Nemoto H.
    • Organizer
      The 20^<th> French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Bordeaux, France
    • Related Report
      2008 Annual Research Report
  • [Presentation] フラン融合縮環系の効率的構築と誘導体化、および抗インフルエンザ活性評価2007

    • Author(s)
      小林 真也、佐々木 和重、鈴木 望美、松谷 裕二、落合 宏、根本 英雄
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野市若里市民文化ホール
    • Year and Date
      2007-10-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] フラン融合縮環系の効率的構築と誘導体化、および抗インフルエンザ活性評価2007

    • Author(s)
      小林真也、佐々木和重、鈴木望美、松谷裕二、落合宏、根本英雄
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野
    • Related Report
      2008 Final Research Report
  • [Remarks] Nemoto H. : "Benzocyclobutene" Synthetic Organic Chemistry and Medicinal Chemistry. The 20th French-Japanese Symposium on Medicinal and Fine Chemistry, 2008. 9. 7-9, Bordeaux, France.(招待講演)

    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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