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Novel Molecular Targeted Therapy for Alopecia/Hairloss via PKCeta

Research Project

Project/Area Number 19590107
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionShowa University

Principal Investigator

OHBA Motoi  Showa University, 腫瘍分子生物学研究所, 講師 (70297018)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsPKC / 分子標的薬 / 再生 / 毛髪 / 再生医療
Research Abstract

PKCηを分子標的とした毛髪再生技術の確立を目指した。第1に、既知のPKCη活性化脂質でであるコレステロール硫酸のナノ粒子化による発毛誘導実験を行った。第2に、新規PKCη活性化剤・転写誘導剤の探索をFRET法を原理としたシステム、PKCηプロモーターを使用したレポーターシステムを用い行った。さらに、PKCηトランスジェニックマウスの解析を通じて、PKCηによる発毛誘導機構の解析を行った。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Functional Characterization of IL-17F as a Selective Neutrophil Attractant in Psoriasis2009

    • Author(s)
      Watanabe H, , Ohba M, Hizawa N, Adachi M, Huang SK, Iijima M. (他6名)
    • Journal Title

      J. Invest. Dermatol. 129(3)

      Pages: 650-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional Characterization of IL-17F as a Selective Neutrophil Attractant in Psoriasis2009

    • Author(s)
      Watanabe H.
    • Journal Title

      J Invest Dermatol. 129(3)

      Pages: 650-656

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Kinase Cα and ζ Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis2008

    • Author(s)
      Park JW, Kim HP, Lee SJ, Wang X, Wang Y, Ifedigbo E, Watkins SC, Ohba M, Ryter S.W., Vyas Y.M., Choi A.M.
    • Journal Title

      J. Immunol. 180(7)

      Pages: 4668-78

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein Kinase Cα and ζ Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis2008

    • Author(s)
      Park J., W., et. al.
    • Journal Title

      J.Immunology 180

      Pages: 4668-4678

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A protein kinase Cε-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2.2007

    • Author(s)
      Steinberg R, Harari OA, Lidington EA, Boyle JJ, Nohadani M, Samarel AM, Ohba M, Haskard DO, Mason JC.
    • Journal Title

      J. J. Biol. Chem. 282(44)

      Pages: 32288-97

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of protein kinaseCζ mediates luteinizing hormone-or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary2007

    • Author(s)
      Park J.I., Kim S.G., Chun J.S., Seo Y.M., Jeon M.J., Ohba M., Kim H.J., Chun S.Y.
    • Journal Title

      Mol. Cell Endocrinol. 270(1-2)

      Pages: 79-86

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of protein・kinase Cζmediates luteinizing hormone-or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary2007

    • Author(s)
      Park J., I, et. al.
    • Journal Title

      Mol.Cell Endocrinol. 270

      Pages: 79-86

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 毛包上皮幹細胞の永代培養法と分化誘導法の確立2009

    • Author(s)
      大場 基
    • Organizer
      昭和大学共同研究成果発表会
    • Place of Presentation
      東京都
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] PKCηを標的分子とした毛髪再生法の開発2008

    • Author(s)
      大場基
    • Organizer
      昭和大学共同研究 研究成果発表会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-01
    • Related Report
      2008 Final Research Report
  • [Presentation] PKCηを標的分子とした毛髪再生法の開発2008

    • Author(s)
      大場 基
    • Organizer
      昭和大学共同研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Relation between MET and EGFR expression in acquired gefetinib-resistant non small lung cancer2008

    • Author(s)
      Kanome. T.
    • Organizer
      AACR Annual Meeting 2008
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Involvement of PKCeta in growth and differentiation of epithelial cells and innate immune response2008

    • Author(s)
      大場基
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] Involvement of PKCeta in growth and differentiation of epithelial cells and innate immune response2008

    • Author(s)
      大場 基
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Related Report
      2008 Annual Research Report
  • [Book] 改訂培養細胞実験ハンドブック2009

    • Publisher
      羊土社
    • Related Report
      2008 Final Research Report
  • [Book] 改訂 培養細胞実験ハンドブック2009

    • Author(s)
      大場 基
    • Total Pages
      329
    • Publisher
      羊土社
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 毛髪再生方法2008

    • Inventor(s)
      大場基、黒木登志夫
    • Industrial Property Rights Holder
      昭和大学、(株)バイオマスター
    • Industrial Property Number
      2004-264736
    • Filing Date
      2008
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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